Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men

Abstract

Norwegian government and Norwegian Cancer Society.

Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review

“…The median follow-up varied from 10.9 to 21.0 years. Long-term outcomes (follow-up up to 21 years) and the effectiveness of FS in combination with FIT screening were investigated only in Northern Europe [33,36]. CRC mortality reductions due to onceonly FS screening ranged from 21% to 30% (point estimates; among those invited compared with among those not invited) [33e35].…”

“…CRC mortality reductions due to onceonly FS screening ranged from 21% to 30% (point estimates; among those invited compared with among those not invited) [33e35]. When FS was offered in combination with the FIT, probability of dying from CRC was 25% lower in the invited group than in the not-invited reference group (RR Z 0.75, 95% CI: 0.57e0.99) [33]. Among participants in the FS screening group, CRC mortality was 38e41% lower in the invited participants than in the not-invited control group (estimates adjusted for demographic differences in non-participants; Fig.…”

Mortality From Postscreening (Interval) Colorectal Cancers Is Comparable to That From Cancer in Unscreened Patients—A Randomized Sigmoidoscopy Trial

“…We took advantage of a randomised controlled sigmoidoscopy screening trial, the Norwegian Colorectal Cancer Prevention (NORCCAP) trial, and compared colorectal cancer-specific and all-cause mortality of individuals with interval colorectal cancer to individuals diagnosed with colorectal cancer in a non-screened control group 21,22 .…”

Colorectal cancer, screening: achievements и opportunities

“…При медиане наблюдения 14,8 года заболеваемость у женщин составила 1,86 % в группе скрининга и 2,05 % в группе контроля, у мужчин -1,72 и 2,50 % соответственно. При этом риск смерти у женщин в группе скрининга составил 0,6 % против 0,59 % в группе контроля, у мужчин -0,49 % против 0,81 % [19].…”