Long-term effect of perfluorocarbon distension on the lung

Intrapulmonary perfluorooctyl bromide instillation in fetal rabbits

“…However, only a minor elevation of heart rate was seen after 3 hours, and no differences in mean heart rates were observed between +lig, Àlig, or cont fetuses in T 0h and T 6h . This is in surprising agreement with the safety of postnatal long-term distension of the lung with PFC [17], considering the higher relative PFOB dose given in the fetuses and the fact that the trachea was occluded in the +lig group.…”

Safety and efficacy of perflubron-induced lung growth in neonates with congenital diaphragmatic hernia: Results of a prospective randomized trial

“…PILG is an innovative postnatal strategy to increase lung growth during ECMO for severe CDH patients. Previous short-term application of PILG (≤1 week) suggested a benefit in lung growth, but animal studies suggested that three weeks of distention is required for sustained lung growth [10,11,14,15]. Therefore, we performed this open-label, prospective, randomized trial to assess the safety and efficacy of PILG for up to three weeks.…”

“…A survival of 6 of 8 (75%) was observed in the PILG group and 3 of 5 (60%) in the conventional mechanical ventilation (CMV) group in that study. Strong evidence from the laboratory indicates that up to 3 weeks are necessary to achieve maximal lung growth using the PILG strategy [11]. Therefore, the purpose of this study was to perform a prospective, randomized clinical trial comparing PILG versus CMV in newborns with left CDH Journal of Pediatric Surgery 50 (2015) 1083-1087 who require ECMO.…”

Postnatal pulmonary distension for the treatment of pulmonary hypoplasia: pilot study in the neonatal piglet model

“…When used as a respiratory medium during liquid ventilation in animals/neonates with CDH, PFC has resulted in some improvements in gas exchange and compliance but does not accelerate lung growth or increase survival [12][13][14]. In contrast, selective PFC distension, which has been performed in both sheep and human neonates, appears promising with respect to increasing postnatal lung growth [8][9][10]15] and survival [11]. To our knowledge, no one has examined the short-term effects of PFC distension on lung growth in healthy neonatal piglets.…”