Long-term effect of moderate and profound hypothermia on morphology, neurological, cognitive and behavioural functions in a rat model of perinatal asphyxia

Hoeger, Harald; Engidawork, Ephrem; Stolzlechner, D.; Bubna-Littitz, Hermann; Lubec, Barbara

doi:10.1007/s00726-006-0393-z

Cited by 30 publications

(26 citation statements)

References 52 publications

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“…Finally, when animals were downshifted from a 32% to a 4% sucrose solution, an attenuated suppression of consummatory behavior was observed in PA rats (Galeano et al, 2011). Despite of these behavioural impairment, neurological motor conditions were comparable to those of normoxic animals, in agreement with results obtained by Hoeger et al (2006).…”

Section: Discussionsupporting

confidence: 91%

“…From a motor point of view, it should be noted that deficits, possibly linked to cerebellar lesions, are observed at very early stages ranging from days to several weeks (Young et al, 1986) but seem to be compensated 3 months after PA (Hoeger et al, 2006). These findings are in line with observations made in humans by Allin et al who reported no correlation between the volume of the underdeveloped cerebellum in preterm children and motor function later in Fig.…”

Section: Discussionsupporting

confidence: 90%

“…Behavioural test were already made using this perinatal asphyxia model by several researcher groups (Hoeger et al, 2006;Loidl et al, 2000;Morales et al, 2010;Strackx et al, 2010;Van de Berg et al, 2003), etc.) including our group (Galeano et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Long lasting cerebellar alterations after perinatal asphyxia in rats

Campanille

Saraceno

Rivière

et al. 2015

Brain Research Bulletin

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

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Long lasting cerebellar alterations after perinatal asphyxia in rats

Campanille

Saraceno

Rivière

et al. 2015

Brain Research Bulletin

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“…Hypothermia and hyperthermia have been shown to protect against and worsen hypoxia/ischemia induced CNS damage, respectively, in perinatal animals, and hypothermia is currently being used clinically to lessen asphyxia-induced brain damage in human neonates (Laptook and Corbett, 2002;Tomimatsu et al, 2003;Cebral et al, 2006;Gunn and Thoresen, 2006;Hoeger et al, 2006). We show that the anoxia-dependent decrease in IL-1b protein was attenuated by carrying out the anoxia under hypothermic conditions compared with normothermia.…”

Section: Discussionmentioning

confidence: 85%

Acute brain cytokine responses after global birth hypoxia in the rat

Ashdown

Joiţa

Luheshi

et al. 2008

J of Neuroscience Research

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The main cause of hypoxic/ischemic brain damage in term human neonates is intrauterine asphyxia, in which the whole body is subjected to hypoxia. Inflammatory cytokines are thought to play an important role in modulating hypoxic/ischemic damage in immature brain. Evidence for this from animal models is based mainly on studies that used a model of carotid artery ligation with hypoxia in postnatal rats. However, little is known about the role of cytokines in brain injury after whole-body hypoxia at the time of birth. This study used a well-established rat model of global birth hypoxia to assess mRNA and protein expression of three key proinflammatory cytokines, interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, (TNF-alpha) in the brain, liver, and kidney of neonates. We observed decreased IL-1beta and TNF-alpha protein, and decreased IL-6 mRNA in brains of neonates in the 2 hr after birth hypoxia but increased IL-6 and IL-1beta in liver compared with vaginally born controls. Increasing the severity of the insult by increasing the period of anoxic exposure further decreased brain IL-1beta, whereas delivering anoxia under hypothermic conditions, known to be neuroprotective, attenuated the decrease in brain IL-1beta. These data suggest that decreased brain levels of inflammatory cytokines may modulate central nervous system responses to global birth hypoxia in rats. Our findings of decreased brain cytokine expression after global birth hypoxia contrast with reports of increased brain cytokines after carotid artery ligation with hypoxia in postnatal rats; possible reasons for these differences are discussed.

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“…Weitzdörfer et al interpreted this finding as a result of both altered neurotransmitter release and compensatory synaptogenesis following PA [52]. The Swedish experimental model was selected for this study for its suitability to evaluate morphology, metabolism, neurochemistry, and long-term effects of PA [54]. …”

Section: Effects Of Experimental Perinatal Asphyxia On Synaptic Ormentioning

confidence: 99%

Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model

et al. 2017

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Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model.

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Long-term effect of moderate and profound hypothermia on morphology, neurological, cognitive and behavioural functions in a rat model of perinatal asphyxia

Cited by 30 publications

References 52 publications

Long lasting cerebellar alterations after perinatal asphyxia in rats

Long lasting cerebellar alterations after perinatal asphyxia in rats

Acute brain cytokine responses after global birth hypoxia in the rat

Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model

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