Long‐term effect of lithium on the uptake of 5‐hydroxytryptamine by human platelets.

Born, G. V. R.; Grignani, G; Martin, Karen

doi:10.1111/j.1365-2125.1980.tb01057.x

Cited by 70 publications

(14 citation statements)

References 15 publications

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“…These results are also in accord, as previously discussed elsewhere (Carli et al, 1997a), with previous studies showing diminished 5-HT uptake in platelets from patients with affective disorders (Coppen et al, 1980;Healy et al, 1983;Meltzer et al, 1981;Tuomisto and Tukiainen, 1976). Indeed, it has been proposed that the chronic administration of Li 1 could help to compensate by elevating the deficient uptake, as shown in patients under lithemic therapy (Born et al, 1980;Coppen et al, 1980;Meltzer et al, 1983;ThiesFlechtner et al, 1994). Also, Abouh-Saleh et al (1992) suggested that patients with enhanced 5-HT uptake, as a result of chronic administration of Li 1 , show a decreased morbidity when compared to patients that had a lower uptake.…”

Section: Discussionsupporting

confidence: 92%

Regulation of central serotonin transporters by chronic lithium: An autoradiographic study

Carli

Reader

1997

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The objectives of this study were to further characterize the effects of a chronic lithium (Li+) treatment on serotonin (5-HT) uptake sites, and to determine the eventual reversibility of the observed effects. Quantitative autoradiography experiments were carried out on sections from rat brain, using [3H]citalopram to label selectively the 5-HT transporters or uptake sites. In these experiments, we were able to saturate the 5-HT transporters using an isotopic dilution of the radioligand. The lowest densities of [3H]citalopram binding were measured in all cortical regions studied, with the highest cortical labelling in the anterior cingulate cortex. The rostral neostriatum presented a moderate density of labelling, with slightly higher levels in its ventral portion. Relatively high densities were measured in the globus pallidus, hippocampus, and hypothalamus. Finally, the highest densities were found in the brain stem. Indeed, the dorsal raphe nuclei as well as the substantia nigra were characterized by very high amounts of [3H]citalopram binding. The chronic administration of Li+ increased the density of 5-HT uptake sites in cortical regions, and significant differences were observed in the frontal, temporal, and entorhinal-piriform cortices, with an elevation, albeit not significant, in the anterior cingulate region. A significant increase was also observed in the lateral hypothalamus. Since the 5-HT uptake sites were studied with saturating concentrations of citalopram, we can propose that this increase in binding densities can be attributed to an increase in the number of 5-HT transporters. Interestingly, the only modifications observed were located in regions containing nerve terminals of 5-HT neurons, while regions with cell bodies remained unaffected. Moreover, these effects were completely reversed following a recovery of 48 h without Li . Also, there were no modifications in the density of 5-HT uptake sites after only 2 days of Li+. These results, suggesting an anatomically heterogenous increase in 5-HT uptake in chronically treated rats, are in accord with clinical observations and previous reports with homogenate binding assays. Finally, the conclusions from this study further support the importance of central 5-HT synaptic transmission in the pathophysiology and treatment of human affective disorders.

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Section: Discussionsupporting

confidence: 92%

Regulation of central serotonin transporters by chronic lithium: An autoradiographic study

Carli

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1997

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“…The reported range for normal subjects is large (12). Most studies have employed platelet-rich plasma (PRP) for estimation (21)(22)(23). 5-HT uptake estimated by this method may be confounded by the presence of protein and other chemicals present in plasma.…”

Section: Discussionmentioning

confidence: 99%

The menstrual cycle and platelet 5-HT uptake.

Tam¹,

Chan²,

Lee³

1985

Psychosomatic Medicine

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The association between the onset of depressive illness and the paramenstruum has been reported. In the present study, we looked at changes in platelet 5-HT uptake in six healthy, regularly menstruating subjects on days 1, 10, and 24 of three consecutive menstrual cycles to explore possible biochemical bases for mood changes associated with menstruation. Platelet 5-hydroxytryptamine (5-HT) uptake was determined by suspension of platelet pellets in 0.5-5 microM hydroxy [G-3H] tryptamine [( 3H]-5-HT) creatinine sulfate solution at 37 degrees C and measurement of radioactivity of [3H]-5-HT in the platelets using liquid scintillation counting. Mood changes were measured using the Moos Menstruation Distress Questionnaire and the Spielberger State Anxiety Scale. Analysis of variance and trend analysis revealed significant elevation of Km and Vmax on day 24 of the cycle, which was consistent across the three menstrual cycles studied. A significant linear rise of "negative affect" across each cycle peaking on day 1 was detected. "Water retention" and "behavioral change" also peaked on day 1. No significant correlation, however, was obtained between the mood scores and platelet 5-HT uptake. These findings are discussed.

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“…Effects of lithium on 5-HT uptake in platelets were demonstrated also in man (Murphy et al, 1969;Born et al, 1980;Coppen et al, 1980;Corona et al, 1982).…”

Section: The Course Of Morning Cortisol Concentrationsmentioning

confidence: 94%

“…Murphy et al (1969) and Born et al (1980) showed that chronic lithium treatment up to three months increased the serotonin uptake in blood platelets of manic-depressive patients. Coppen et al (1980) reported an increased uptake ofplatelets 5-HT after lithium treatment of six weeks, one year, and after lithium prophylaxis of 4.3 years on average.…”

Section: Introductionmentioning

confidence: 98%

Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man

Mühlbauer

Müller‐Oerlinghausen

1985

J. Neural Transmission

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In order to investigate the influence of lithium long-term medication on serotonergic neurotransmission, fenfluramine stimulation (FFS) was used for the assessment of hormonal effects under serotonergic control. The cortisol plasma concentration following FFS was examined between 8 a.m. and 1 p.m. in 11 manic-depressive subjects under lithium prophylaxis and in 8 untreated euthymic patients. In addition, 11 healthy subjects with FFS, and 12 other subjects without FFS were investigated. The basal cortisol concentrations show considerable variation. Those of the lithium patients were in general found lower than those of the control groups. In both, the controls and the manic-depressive patients without lithium medication, no gross deviation from the expected physiological decline of morning cortisol values was found. A subtle effect of FFS in healthy subjects could be observed. In the lithium patients, however, a significant inversion of the cortisol secretion pattern with a steep increase between 10 and 12 a.m. could be demonstrated. It is concluded that FFS and lithium long-term medication exert an agonistic influence onto central serotonergic neurotransmission. Pharmacological challenge with fenfluramine may prove to be a useful tool for the investigation of serotonergic mechanisms in biological psychiatry.

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Long‐term effect of lithium on the uptake of 5‐hydroxytryptamine by human platelets.

Cited by 70 publications

References 15 publications

Regulation of central serotonin transporters by chronic lithium: An autoradiographic study

Regulation of central serotonin transporters by chronic lithium: An autoradiographic study

The menstrual cycle and platelet 5-HT uptake.

Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man

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