Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes

Kostis, John B.; Wilson, Alan C.; Freudenberger, Ronald S; Cosgrove, Nora M.; Pressel, Sara L.; Davis, Barry R.

doi:10.1016/j.amjcard.2004.08.059

Cited by 307 publications

(185 citation statements)

References 34 publications

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“…The decline might be less than predicted based on epidemiological data on diabetes and CV morbidity and mortality, however, because whether the prognostic value of druginduced diabetes is equivalent to that of native diabetes is still uncertain (36). This has been reported to be the case in some studies (37,38), whereas in other studies, a few years or even long-term exposure to diabetes induced by antihypertensive drugs was not found to increase CV morbid or fatal events (24,39).…”

Section: Implications For Benefits Of Statin Treatmentmentioning

confidence: 96%

Statins and the Risk of Diabetes: Evidence From a Large Population-Based Cohort Study

et al. 2014

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OBJECTIVETo investigate the relationship between adherence with statin therapy and the risk of developing diabetes. RESEARCH DESIGN AND METHODSThe cohort comprised 115,709 residents of the Italian Lombardy region who were newly treated with statins during 2003 and 2004. Patients were followed from the index prescription until 2010. During this period, patients who began therapy with an antidiabetic agent or were hospitalized for a main diagnosis of type 2 diabetes were identified (outcome). Adherence was measured by the proportion of days covered (PDC) with statins (exposure). A proportional hazards model was fitted to estimate hazard ratios (HRs) and 95% CIs for the exposure-outcome association, after adjusting for several covariates. A set of sensitivity analyses was performed to account for sources of systematic uncertainty. RESULTSDuring follow-up, 11,154 cohort members experienced the outcome. Compared with patients with very-low adherence (PDC <25%), those with low (26-50%), intermediate (51-75%), and high ( ‡75%) adherence to statin therapy had HRs (95% CIs)

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Section: Implications For Benefits Of Statin Treatmentmentioning

confidence: 96%

Statins and the Risk of Diabetes: Evidence From a Large Population-Based Cohort Study

et al. 2014

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“…7 In addition, in a 14-year follow-up study of patients from the Systolic Hypertension in the Elderly Program (SHEP), the investigators did not find an increased risk of mortality among patients who developed diabetes during the trial while receiving chlorthalidone compared with patients who developed diabetes during the trial but received placebo. 8 The controversy surrounding the association between thiazide diuretics and the development of diabetes requires further investigation.…”

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confidence: 99%

Thiazide Diuretics, Potassium, and the Development of Diabetes

et al. 2006

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Abstract-National guidelines and a recent clinical trial have supported the use of thiazide diuretics as the preferred initial pharmacological treatment for hypertension. However, evidence from this and other clinical trials have also found an increased incidence of new onset diabetes among those patients receiving thiazide diuretics. The mechanisms responsible for the increased incidence of diabetes with thiazide diuretics have not been fully elucidated. This article provides a review of intervention studies that included data on the relation between thiazide-induced hypokalemia and glucose intolerance.

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“…The analyses from the Systolic Hypertension in the Elderly Program Extension (SHEP-X) were the most robust by far, because of the large sample size and hard end points (especially, CVD mortality); IDM in the group randomized to chlorthalidone during the 5-year trial had no effect on subsequent risk, in contrast to the effect of IDM occurring on placebo. 7 Also, SHEP-X had the least contamination with other drugs in the regimen, whereas in the other studies, most patients were on multidrug regimens, and the percentage on thiazide alone was small. Another study found the effect of FBG change on risk of myocardial infarction to be higher in treated hypertensive patients compared with nonhypertensive persons, but it has been criticized for this design and because it adjusted differentially for blood pressure in the 2 groups.…”

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confidence: 80%

Thiazide-Associated Glucose Abnormalities: Prognosis, Etiology, and Prevention

Cutler

2006

Hypertension

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Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes

Cited by 307 publications

References 34 publications

Statins and the Risk of Diabetes: Evidence From a Large Population-Based Cohort Study

Statins and the Risk of Diabetes: Evidence From a Large Population-Based Cohort Study

Thiazide Diuretics, Potassium, and the Development of Diabetes

Thiazide-Associated Glucose Abnormalities: Prognosis, Etiology, and Prevention

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