Long Term Effect of Biodegradable Polymer on Oxidative

Surendran, Divya; Kumar, Rajeev; Geetha, C.S.; Mohanan, P.V.

doi:10.5618/bio.2012.v2.n1.4

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Moreover, neither cell viability nor membrane integrity appeared significantly affected by PCL-induced oxidative stress with respect to control cells at any culture time. In a longer term study, no change has been observed in the levels of LPO or of glutathione at either 3 or 12 months after implantation of PCL materials in rats compared to polyglactin controls [110]. However, PCL materials usually degrade for periods longer than 18 months, meaning that the authors failed to investigate the effect of the final stage of degradation of the material, during which it fragments into small particles.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Biocompatibility of implantable materials: An oxidative stress viewpoint

et al. 2016

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Oxidative stress occurs when the production of oxidants surpasses the antioxidant capacity in living cells. Oxidative stress is implicated in a number of pathological conditions such as cardiovascular and neurodegenerative diseases but it also has crucial roles in the regulation of cellular activities. Over the last few decades, many studies have identified significant connections between oxidative stress, inflammation and healing. In particular, increasing evidence indicates that the production of oxidants and the cellular response to oxidative stress are intricately connected to the fate of implanted biomaterials. This review article provides an overview of the major mechanisms underlying the link between oxidative stress and the biocompatibility of biomaterials. ROS, RNS and lipid peroxidation products act as chemo-attractants, signalling molecules and agents of degradation during the inflammation and healing phases. As chemo-attractants and signalling molecules, they contribute to the recruitment and activation of inflammatory and healing cells, which in turn produce more oxidants. As agents of degradation, they contribute to the maturation of the extracellular matrix at the healing site and to the degradation of the implanted material. Oxidative stress is itself influenced by the material properties, such as by their composition, their surface properties and their degradation products. Because both cells and materials produce and react with oxidants, oxidative stress may be the most direct route mediating the communication between cells and materials. Improved understanding of the oxidative stress mechanisms following biomaterial implantation may therefore help the development of new biomaterials with enhanced biocompatibility.

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Section: Accepted Manuscriptmentioning

confidence: 98%

Biocompatibility of implantable materials: An oxidative stress viewpoint

et al. 2016

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“…It is possible that PGA has a protective effect against genotoxicity, however further studies are needed to firmly prove this hypothesis [54]. While analyzing literature data, we have found only one study on the genotoxicity of blank PCL nanoparticles [55] which demonstrates that PCL nanoparticles are not genotoxic in rats in vivo after three months, as well as twelve months of intraperitoneal implantation. In that study, 8-hydroxy-2'deoxy guanosine and chromosomal aberrations were used as genotoxicity markers.…”

Section: Induction Of Dna Strand Breaksmentioning

confidence: 90%

Synthesis of poly(ɛ-caprolactone) nanospheres in the presence of the protective agent poly(glutamic acid) and their cytotoxicity, genotoxicity and ability to induce oxidative stress in HepG2 cells

Filipović

Stevanović

Nunić

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Nanospheres of poly(ɛ-caprolactone) (PCL) with sizes smaller than 200 nm were produced by combining the freeze drying method and the physicochemical solvent/non-solvent approach. The influence of various types of cryoprotectants (poly(glutamic acid) (PGA) or sacharose) and their concentrations on the outcome of freeze-dried poly(ɛ-caprolactone) particles was evaluated. The physiochemical properties, structural and morphological characteristics of thereby obtained PCL particles were determined by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The cytotoxicity of the samples was examined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT assay). The formation of intracellular reactive oxygen species was measured spectrophotometrically using a fluorescent probe (DCFH-DA assay). In addition, the genotoxic response of PCL particles obtained using PGA as a cryoprotectant was investigated by the Comet assay. This paper focuses on the role of PGA in the synthesis of PCL particles and demonstrates that PGA plays a dual role in the synthesis, i.e. it acts as a stabilizer but also as a cryoprotective agent. The sufficient and optimal concentration of PGA for producing uniform, spherical but also biocompatible PCL nanoparticles is established to be 0.05%.

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“…They are primarily composed of polyester-based materials, predominantly polycaprolactone (PCL) [ 2 ]. PCL is not commonly associated with causing allergic contact dermatitis reactions and is considered a non-toxic polyester [ 3 ]. There are very few reports of patients experiencing allergic contact dermatitis reactions to thermoplastic masks in the medical literature.…”

Section: Introductionmentioning

confidence: 99%

Thermoplastic Mask-Induced Contact Dermatitis: A Case Report

Cappelli¹,

Poiset²,

Greenberger³

et al. 2022

Cureus

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Thermoplastic masks are commonly used in radiation therapy to immobilize a patient's head and neck during treatment. They are primarily composed of non-toxic polyester compounds that can be manipulated with heat to mold the shape of a patient's head and neck. There is little previously reported evidence of these masks causing allergic contact dermatitis. We present a case of a 44-year-old female with a history of squamous cell carcinoma of the right tonsil with multiple enlarged lymph nodes following surgical excision of the right tonsillar mass and ipsilateral neck dissection elected to undergo adjuvant radiation therapy with volumetric modulated arc therapy (VMAT) technique without concurrent chemotherapy. A thermoplastic mask was issued prior to radiation therapy. Following the mask fitting, the patient developed an allergic contact dermatitis reaction of the head and neck in areas covered by the mask. Her symptoms worsened with continued use of the thermoplastic mask and radiation therapy. As the patient continued and eventually finished the radiation treatment regimen, the dermatologic symptoms failed to respond to topical facial moisturizer and steroid treatment. The contact dermatitis reaction did not completely dissipate until about three months following completion of radiation therapy and contact with the thermoplastic mask. Thermoplastic masks are not known to cause an allergic contact dermatitis reaction. There is only one other reported case documented in the literature. Such reactions can alter the course of radiation therapy if symptoms are severe enough to disrupt treatment or if they cause worsening of the radiation dermatitis. Allergic contact dermatitis to thermoplastic masks should be well documented in the future to better understand the cause and possible risk factors related to the reaction.

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Long Term Effect of Biodegradable Polymer on Oxidative

Cited by 5 publications

References 25 publications

Biocompatibility of implantable materials: An oxidative stress viewpoint

Biocompatibility of implantable materials: An oxidative stress viewpoint

Synthesis of poly(ɛ-caprolactone) nanospheres in the presence of the protective agent poly(glutamic acid) and their cytotoxicity, genotoxicity and ability to induce oxidative stress in HepG2 cells

Thermoplastic Mask-Induced Contact Dermatitis: A Case Report

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