Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

Provenza, Nicole R.; Sheth, Sameer A.; Rijn, Evan M. Dastin-van; Mathura, Raissa; Ding, Yaohan; Vogt, Gregory L.; Avendaño-Ortega, Michelle; Ramakrishnan, Nithya; Peled, Nir; Gelin, Luiz Fernando Fracassi; Xing, David; Jeni, László A.; Ertuğrul, Itır Önal; Barrios-Anderson, Adriel; Matteson, Evan; Wiese, Andrew D.; Xu, Junqian; Viswanathan, Ashwin; Harrison, Matthew T.; Bijanki, Kelly R.; Storch, Eric A.; Cohn, Jeffrey F.; Goodman, Wayne K.; Borton, David A.

doi:10.1038/s41591-021-01550-z

Cited by 63 publications

(55 citation statements)

References 91 publications

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“…Thus, a lower LFP delta band in the OFC of Sapap3-KO mice may underlie impaired recruitment of downstream striatal PVI networks and, thus, a decreased regulation of compulsive-like behaviours. Our findings also echo a recent study in OCD patients implanted with recordingcapable DBS devices; the authors showed that LFP signals recorded in the striatum were cooccurring with OCD symptoms and detected a signature of interest in the delta-band, as we observed in our study 35 .…”

Section: Discussionsupporting

confidence: 93%

Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviours

Mondragón-González

Schreiweis

Burguière

2022

Preprint

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A prominent electrophysiological feature of compulsive behaviours is striatal hyperactivity; but its underlying dysfunctional cellular mechanisms still need to be characterized. Within the striatum, parvalbumin-positive interneurons (PVI) exert a powerful feedforward inhibition essential for the regulation of striatal activity. To investigate the potential implication of striatal PVI in aberrant repetitive behaviors, we used the Sapap3 mutant mice which exhibit compulsive-like behaviours characterized by excessive self-grooming. When striatal PVI in the centromedial striatum of Sapap3 mice were we optogenetically activated, we first showed that the number of compulsive-like events were greatly reduced. To investigate further the critical time-window when striatal PVI needed to be recruited for the behavioural regulation of compulsive-like grooming, we then designed a novel closed-loop stimulation pipeline. We identified a transient 1-4 Hz oscillations in the orbitofrontal cortex that temporally predicted grooming onsets. Exploiting this delta band signal as a biomarker, we were able to provide on-demand stimulation of striatal PVI shortly before predicted grooming events. This targeted closed-loop optogenetics approach greatly reduced grooming events and demonstrated that the recruitment of striatal PVI regulated the initiations of compulsive-like behaviours.

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Section: Discussionsupporting

confidence: 93%

Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviours

Mondragón-González

Schreiweis

Burguière

2022

Preprint

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“…Informal (non-standardized) symptom provocation has typically been part of the post-operative parameter selection procedure at our center. Furthermore, as mentioned above, acute 'improvement' with DBS has been described repeatedly (e.g., reduction of anxiety and tension, smiling, lightened mood), although it is important to note that comprehensive symptom relief often takes much more time to develop (Denys et al, 2010;Luyten et al, 2016;Okun et al, 2007;Provenza et al, 2021;Tsai et al, 2014;Winter et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Deep brain stimulation in the bed nucleus of the stria terminalis: A symptom provocation study in patients with obsessive-compulsive disorder

Luyck

Bervoets

Deblieck³

et al. 2022

Journal of Psychiatric Research

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“…Recent investigational devices, for example the Medtronic Summit RC+S [8], BrainGate iBCI [13], and Neuralink [14] solve both of these limitations via rechargeable cell batteries and chronic, real-time streaming of neural data to external devices meters away. These advances allow access to long timescale neural recordings in natural environments, enabling the identification and development of personalized biomarkers and therapies [6,7,15,16].…”

Section: Introductionmentioning

confidence: 99%

PELP: accounting for missing data in neural time series by Periodic Estimation of Lost Packets

Rijn

Provenza

Goodman

et al. 2022

Preprint

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Objective. Implanted electrical stimulators with sensing capabilities have enabled the development of closed-loop neuromodulation therapies capable of responding to patient needs in real-time. Through a combination of rechargeable technologies and wireless data transmission, it is now possible for researchers to acquire extensive neural recordings from human participants in naturalistic settings using these bidirectional devices. However, data losses during wireless transmission hamper processing and the identification of neural signals of interest, driving the need for methodologies to properly estimate the impact of data loss. Approach. To accurately reconstruct the timing of data containing losses, we have developed a method called Periodic Estimation of Lost Packets (PELP) to precisely determine the number of samples lost from implanted recordings during active stimulation. PELP leverages a data-driven procedure for determining the period of stimulation and the knowledge that stimulation continues identically during periods where data are missing to accurately account for the number of samples lost. Main results. Using simulated stimulation added to collected human EEG data, we show that PELP is robust to a range of stimulation waveforms and noise characteristics. Lastly, we successfully applied PELP to local field potential (LFP) recordings from an implanted, bidirectional device using data recorded in the clinic and the patient's own home. Significance. By effectively accounting for the timing of missing data, PELP enables the analysis of complex, naturalistic neural time series data from bidirectional implanted devices aiding in the development of novel therapeutic approaches. NCT04806516 (ClinicalTrials.gov).

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Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

Cited by 63 publications

References 91 publications

Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviours

Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviours

Deep brain stimulation in the bed nucleus of the stria terminalis: A symptom provocation study in patients with obsessive-compulsive disorder

PELP: accounting for missing data in neural time series by Periodic Estimation of Lost Packets

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