Long-term disease-free survival after plasmacytoma of the urethra: a case report and review of the literature

Mordkin, Robert; Skinner, Donald G.; Levine, Alexandra M.

doi:10.1016/s0090-4295(96)00102-1

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…There are only eight published cases of urethral extramedullary plasmacytoma. 3–10 Five of these patients were treated with primary radiotherapy, four of whom remained disease free at follow up (ranging from six months to 12 years), the other relapsing at one year, requiring a urethrectomy. The remaining three had primary surgical excision with or without adjuvant radiotherapy and remained recurrence free at follow up (ranging from six months to 10 years).…”

Section: Discussionmentioning

confidence: 99%

Urethral involvement of myeloma: A rare case of visible haematuria leading to a diagnosis of relapsed multiple myeloma after curative stem cell transplantation

Patel

Irwin

Dey

2015

Journal of Clinical Urology

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A 45-year-old man presented in June 2014 with painless visible haematuria and no other lower urinary tract symptoms. Examination revealed normal external genitalia and a small benign-feeling prostate. Haemoglobin, white cell count, renal function and adjusted calcium were within normal limits. The patient had curative autologous stem cell transplantation for multiple myeloma previously in January 2013. Flexible cysto-urethroscopy revealed a pedunculated, 'polyp-like' lesion arising from the ventral aspect of the mid-urethra (Figure 1) and normal bladder urothelium. Transurethral resection under general anaesthetic was performed. Histology showed a poorly differentiated neoplasm with malignant plasma cell infiltrate of plasmablastic morphology. The cells were strongly positive for CD138 (Figure 2) and negative for CD79a, CAM5.2, p63 and MNF116 (Figure 3) on immunohistochemistry. A provisional diagnosis of myeloma recurrence was made. Further staging investigations revealed a para-spinal and rib lesion. Biopsy of the latter revealed plasma cell myeloma confirming relapse. Chemotherapy was initiated. Discussion Multiple myeloma accounts for 0.8% of all new cancer cases annually. Soft tissue deposits of myeloma are usually confined to the liver, spleen, lymph nodes, nasopharyngeal and para-nasal sinuses. 1-2 Urethral involvement is exceptionally rare (either in isolation (extramedullary plasmacytoma) or with bony involvement (multiple myeloma)). There are only eight published cases of urethral extramedullary plasmacytoma. 3-10 Five of these patients were treated with primary radiotherapy, four of whom remained disease free at follow up (ranging from six months to 12 years), the other relapsing at one year, requiring a urethrectomy. The remaining three had primary surgical excision with or without adjuvant radiotherapy and remained recurrence free at follow up (ranging from six months to 10 years). Up to 50%

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Section: Discussionmentioning

confidence: 99%

Urethral involvement of myeloma: A rare case of visible haematuria leading to a diagnosis of relapsed multiple myeloma after curative stem cell transplantation

Patel

Irwin

Dey

2015

Journal of Clinical Urology

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“…Concerning the urinary tract EMP has been described in just a few case reports in kidney, urinary bladder and urethra [4][5][6] .…”

Section: Discussionmentioning

confidence: 99%

“…To date there are no data supporting a beneficial role of adjuvant chemotherapy [9,10] . Experience with EMP in the urinary tract shows that surgery (and/or radiotherapy) is the preferred treatment [4][5][6] .…”

Section: Discussionmentioning

confidence: 99%

The First Description of an Extramedullary Plasmacytoma of the Ureter

Klein¹,

Holz²,

Neid³

et al. 2010

Urol Int

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Causes for acquired unilateral obstruction of the ureter are numerous: calculi, infections, blood clots and tumors are the most common underlying pathologies. Hematologic tumors with initial clinical manifestation in the lower urinary tract are rare. Primary localization of plasmocytoma has been described in kidney, bladder and urethra. Herein, we describe the first manifestation of a primary solitary extramedullary plasmacytoma of the ureter. The tumor was discovered upon diagnostic workup of gross hematuria and asymptomatic hydronephrosis. Thus far, after radical surgery the patient remains free of disease.

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“…This patient received radiotherapy with a total dose of 41.4 Gy as definitive treatment modality. The patient had a 12-year disease-free follow-up without any significant longterm side-effects [8]. The role of radiotherapy in the palliative treatment of multiple myeloma is established as an effective treatment modality [12].…”

Section: Discussionmentioning

confidence: 99%

“…A few cases of plasmocytomas of the kidney, the testicle and the bladder have been reported [2][3][4][5]. To date, only 3 cases of primary plasmocytoma of the urethra are described [6][7][8]. We describe a fourth case of a 35-year-old male patient with the diagnosis of extramedullary plasmocytoma of the urethra, who could be treated successfully by external beam radiotherapy.…”

Section: Introductionmentioning

confidence: 91%

Plasmocytoma of the Urethra

et al. 2004

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Case History and Findings: A 35-year-old male patient presented with a 1-year history of hesitancy in voiding. An urethrogram revealed urethral stricture, therefore an urethrotomy with biopsies was performed. Histologic results suggested the diagnosis of extramedullary mature plasmocytoma. Treatment and Outcome: After external beam radiotherapy with a total dose of 45 Gy the patient is disease-free without any therapy-related late effects after a follow-up of 36 months. Conclusion: Primary localization of extramedullar plasmocytomas in the genitourinary tract is very rare. This case report discusses a case of a male patient suffering from plasmocytoma of the urethra, who could be treated successfully by primary external beam radiotherapy.

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Long-term disease-free survival after plasmacytoma of the urethra: a case report and review of the literature

Cited by 6 publications

References 6 publications

Urethral involvement of myeloma: A rare case of visible haematuria leading to a diagnosis of relapsed multiple myeloma after curative stem cell transplantation

Urethral involvement of myeloma: A rare case of visible haematuria leading to a diagnosis of relapsed multiple myeloma after curative stem cell transplantation

The First Description of an Extramedullary Plasmacytoma of the Ureter

Plasmocytoma of the Urethra

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