“…Many organic Se compounds have been shown to have therapeutic effects in AD mice models (Xie et al, 2017(Xie et al, , 2018Zhang et al, 2017aZhang et al, , 2018. Through a series of studies, Zhang et al showed that selenomethionine enhanced the antioxidant capacity, mitigated Aβ and tau pathology, reversed synaptic deficits, and ameliorated cognitive decline in AD mice (Song et al, 2014;Zhang et al, 2016Zhang et al, , 2017aZhang et al, , 2018, demonstrating the multitarget effect of Se in AD treatment. Furthermore, impaired autophagy (Zhang et al, 2017b,c;Song et al, 2018) and mitochondrial dysfunction (Balaban et al, 2017) have been shown to be the targets of Se compounds in AD.…”