Long-term dietary restriction causes negative effects on cognitive functions in rats

Yanai, Shuichi; Okaichi, Yoko; Okaichi, Hiroshige

doi:10.1016/s0197-4580(03)00115-5

Cited by 93 publications

(83 citation statements)

References 37 publications

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“…During acquisition training results on escape response latency demonstrated significant age differences that were attenuated when aged AL rats were restricted by diet. Clearly, these results suggest a beneficial effect of DR on spatial learning in acquisition training and replicate previous reports, indicating that DR attenuates the age-related impairments of performance in the MWM as indexed by the latency measure [6,20,30]. The individual data scores in Figures 5a-d clearly indicate a beneficial effect of DR on the motor domain, reflected by locomotor activity and motor strength, and the dimension of cognitive function reflected by escape response latency.…”

Section: Discussionsupporting

confidence: 88%

“…Because results for escape latency and travel distance were similar and highly correlated we focus specifically on latency to the platform for the more detailed evaluation of performance. The most important reason for including escape latency, within the design, as the dependent variable derived from the fact that many of the studies that assess chronic adult DR effects in spatial memory processes, rely primarily on latency measures [6,13,20,24,30].…”

Section: Methodsmentioning

confidence: 99%

“…Our understanding of the nature of DR and how it regulates the onset and rate of aging processes remains to be established. There is an impressive body of evidence showing that DR increases rats' maximum life span and reduces diseases [14,19,20]. The generality of this phenomenon across a number of species suggests that DR may be used as an important model in studying aging-related processes [1,7,8].…”

mentioning

confidence: 99%

“…The majority of studies focusing on spatial memory and learning use the Morris water maze [23] and more specifically report a preservation of age-related cognitive deterioration by chronic adult DR in spatial reference and working memory [6,7]. However, there are several studies with contrary results [1,20,24], suggesting that effects of DR on age-related processes in cognition seems to be much more constrained than its effects on longevity. Some literature even indicates that chronic calorie restriction may damage brain regions important to learning and memory [25][26][27].…”

mentioning

confidence: 99%

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Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Fitting¹,

Booze²,

Gilbert³

et al. 2008

Physiology & Behavior

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Dietary restriction (DR) has been shown to increase life span and reduce disease incidence across a variety of species. Recent research suggests that chronic adult DR may also alter age-related cognitive decline. The purpose of this study was twofold: (1) to examine the potential deficits in spatial learning ability in the aged F344 X BN hybrid F1 rat with specific attention to the contributory effects of motoric impairments and (2) to determine the influence of chronic adult DR on any such impairments. The Morris water maze (MWM) task was employed with a 1.8 m diameter tank, 10 cm 2 escape platform, 28°C water, and an automated collapsing central starting platform. Spatial learning impairments in the aged rats were evident on all dependent measures during training and the probe test. Motoric function, as reflected in measures of strength and locomotion demonstrated profound age-related performance impairments that were attenuated by chronic adult DR. The present data also replicate previous reports, indicating that DR attenuates the age-related impairments of performance in the MWM as indexed by the latency measure in acquisition, but critically was dissociated from any DR effect on measures of preference and, more critically, accuracy in the probe test. Collectively, the most parsimonious interpretation of DR effects on MWM performance would appear to be the preservation of motoric, and not cognitive, function. KeywordsCognition; Motoric function; Morris water maze One of the more disconcerting age-related changes across a variety of species is a decline in learning and memory. Aging rodents have been shown to be a promising animal model for studying memory deficits. In particular, tasks of spatial memory have been employed [1][2][3][4][5][6][7][8] with clearly demonstrated deficits in aged rats as a model associated with aging humans [9][10][11]. Deficits that accompany the decline of spatial learning and memory in aged rats include a loss of visual acuity [12], thermoregulatory control [3], impairments in sensorimotor behavior [6,8,13], and the development of lesions and diseases [14]. These

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Fitting¹,

Booze²,

Gilbert³

et al. 2008

Physiology & Behavior

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show abstract

“…Furthermore, there are controversial reports on the effects of CR and EE on cognition in young animals. Some investigators demonstrated that CR enhances learning and memory [27], while others have reported that CR had negative effects on cognitive functions [28]. Environmental enrichment has also been reported to improve spatial memory in aged mice with no significant effect in young and middle-aged mice [29].…”

Section: Introductionmentioning

confidence: 99%

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Muhammad

Magaji

Mohammed

et al. 2014

Advances in Neuroscience

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Caloric restriction and environmental enrichment have been separately reported to possess health benefits such as improvement in motor and cognitive functions. Resveratrol, a natural polyphenolic compound, has been reported to be caloric restriction mimetic. This study therefore aims to investigate the potential benefit of the combination of resveratrol as CR and EE on learning and memory, motor coordination, and motor endurance in young healthy mice. Fifty mice of both sexes were randomly divided into five groups of 10 animals each: group I animals received carboxymethylcellulose (CMC) orally per kg/day (control), group II animals were maintained on every other day feeding, group III animals received resveratrol 50 mg/kg, suspended in 10 g/L of (CMC) orally per kg/day, group IV animals received CMC and were kept in an enriched environment, and group V animals received resveratrol 50 mg/kg and were kept in EE. The treatment lasted for four weeks. On days 26, 27, and 28 of the study period, the animals were subjected to neurobehavioural evaluation. The results obtained showed that there was no significant change ( > 0.05) in neurobehavioural responses in all the groups when compared to the control which indicates that 50 mg/kg of resveratrol administration and EE have no significant effects on neurobehavioural responses in young healthy mice over a period of four weeks.

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Overview of age‐related changes in psychomotor and cognitive functions in a prosimian primate, the gray mouse lemur (Microcebus murinus): Recent advances in risk factors and antiaging interventions

Chaudron

Pifferi

Aujard

2021

American J Primatol

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Aging is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. Impaired glucose homeostasis is a major risk factor for cognitive decline in middle‐aged humans, pointing at the existence of early markers of unhealthy aging. The gray mouse lemur (Microcebus murinus), a small lemuriform Malagasy primate, shows relatively slow aging with decreased psychomotor capacities at middle‐age (around 5‐year old). In some cases (∼10%), it spontaneously leads to pathological aging. In this case, some age‐related deficits, such as severe cognitive decline, brain atrophy, amyloidosis, and glucoregulatory imbalance are congruent with what is observed in humans. In the present review, we inventory the changes occurring in psychomotor and cognitive functions during healthy and pathological aging in mouse lemur. It includes a summary of the cerebral, metabolic, and cellular alterations that occur during aging and their relation to cognitive decline. As nutrition is one of the major nonpharmacological antiaging strategies with major potential effects on cognitive performances, we also discuss its role in brain functions and cognitive decline in this species. We show that the overall approach of aging studies in the gray mouse lemur offers promising ways of investigation for understanding, prevention, and treatments of pathological aging in humans.

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Long-term dietary restriction causes negative effects on cognitive functions in rats

Cited by 93 publications

References 37 publications

Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Overview of age‐related changes in psychomotor and cognitive functions in a prosimian primate, the gray mouse lemur (Microcebus murinus): Recent advances in risk factors and antiaging interventions

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