Long-term dietary l-arginine supplementation attenuates proteinuria and focal glomerulosclerosis in experimental chronic renal transplant failure

Albrecht, Ester W.J.A.; Goor, Harry van; Oosten, Annemieke Smit-van; Stegeman, Coen A.

doi:10.1016/s1089-8603(02)00132-5

Cited by 24 publications

(16 citation statements)

References 25 publications

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“…Furthermore, these pharmacological actions are consistent with the fact that glomerular sclerosis may be attributed to capillary or arteriolar vasospasm and ischaemia, a process that is known to occur at the arterial level in the heart of the cp/cp rat [13]. Our results are also consistent with those of Albrecht et al [35], who reported that chronic treatment with approximately 1.5 g kg −1 day −1 of arginine (chemical form unspecified) showed significant reduction in transplant-associated glomerular sclerosis in rats. These authors demonstrated a significant reduction in the expression of interstitial alpha smooth muscle actin in L-argininetreated animals, which in turn is thought to be partly responsible for the increased interstitial fibrosis associated with sclerotic damage [36].…”

Section: Discussionsupporting

confidence: 93%

A novel complex of arginine–silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats

2005

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Aims/hypothesis: The metabolic syndrome, with associated vasculopathy, is a major cause of cardiovascular disease and nephropathy. Impaired nitric oxide (NO) metabolism and endothelial function is an important component of the disease process. Increasing the availability of arginine, the precursor of NO, might enhance vascular function and protect against end-stage disease. Materials and methods: Insulin-resistant JCR:LA-cp rats were treated with arginine-silicate-inositol complex or arginine-HCl at 1.0 g kg −1 day −1 (expressed as arginine-HCl) from 8 to 13 weeks of age. The contractile/relaxant function of thoracic aortae and coronary arteries was assessed in vitro. Kidneys were assessed for severity of glomerular sclerosis. Results: Arginine-silicate complex, but not arginineHCl, normalised the hypercontractile response of the aorta to phenylephrine via an NO-dependent pathway. Coronary artery function, as indicated by reactive hyperaemia to warm ischaemia, was enhanced by both arginine compounds. In addition, the arginine-silicate complex increased coronary vasodilatation in response to bradykinin. Glomerular sclerosis was significantly reduced in rats treated with the arginine-silicate complex. Conclusions/ interpretation: Treatment with exogenous arginine, in an efficiently absorbed form, improves vascular function and reduces nephropathy in an animal model of insulin resistance and cardiovascular disease, via mechanism(s) independent of insulin concentration. Enhancement of NO metabolism through increased availability of the precursor arginine appears to offer protection against microand macrovascular disease associated with the metabolic syndrome and insulin resistance.

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Section: Discussionsupporting

confidence: 93%

A novel complex of arginine–silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats

2005

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“…Inhibition of superoxide anion release with apocynin and diphenyleneiodonium prevented allograft fibrosis in the Fisher-to-Lewis model and antagonized the profibrotic effects of cyclosporine A (324,325). L-arginine, but not vitamin E, another antioxidant, exerted similar effects (326,327). With respect to fibrosis, the family of NADP(H) oxidases (NOX) is of interest since they generate ROS in tissue.…”

Section: Oxidative Stressmentioning

confidence: 99%

Renal Allograft Fibrosis: Biology and Therapeutic Targets

Floege

2015

American Journal of Transplantation

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“…Vitamin E (a-tocopherol) supplementation did not prevent allograft injury in a model of CAN; 16 however, in the same model, L-arginine did attenuate proteinuria and glomerulosclerosis. 18 Furthermore, a clinical trial using recombinant human superoxide dismutase resulted in significantly decreased acute and chronic rejection. 19 Therefore, based on the seemingly conflicting results of these few studies, there is a need for additional investigations into the applicability of antioxidants for the prevention of CAN.…”

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confidence: 99%

Oral hydrogen water prevents chronic allograft nephropathy in rats

Cardinal

Zhan

Wang

et al. 2010

Kidney International

160

135

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Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway recipients that had undergone bilateral nephrectomy. Molecular hydrogen was dissolved in water and recipients were given HW from day 0 until day 150. Rats that were treated with regular water (RW) gradually developed proteinuria and their creatinine clearance declined, ultimately leading to graft failure secondary to CAN. In contrast, treatment with HW improved allograft function, slowed the progression of CAN, reduced oxidant injury and inflammatory mediator production, and improved overall survival. Inflammatory signaling pathways, such as mitogen-activated protein kinases, were less activated in renal allografts from HW-treated rats as compared with RW-treated rats. Hence, oral HW is an effective antioxidant and antiinflammatory agent that prevented CAN, improved survival of rat renal allografts, and may be of therapeutic value in the setting of transplantation.

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Long-term dietary l-arginine supplementation attenuates proteinuria and focal glomerulosclerosis in experimental chronic renal transplant failure

Cited by 24 publications

References 25 publications

A novel complex of arginine–silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats

A novel complex of arginine–silicate improves micro- and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats

Renal Allograft Fibrosis: Biology and Therapeutic Targets

Oral hydrogen water prevents chronic allograft nephropathy in rats

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