Long-term deficits in risky decision-making after traumatic brain injury on a rat analog of the Iowa gambling task

Shaver, Trinity K.; Ozga, Jenny E.; Zhu, Binxing; Anderson, Karen G.; Martens, Kris M.; Haar, Cole Vonder

doi:10.1016/j.brainres.2018.10.004

Cited by 29 publications

(29 citation statements)

References 66 publications

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“…Similarly, a recent case-control study by Bhatti et al [28] found that prior TBI was a significant predictor of subsequent gambling problems, particularly among middle-aged men, those who reported alcohol or tobacco use, and those who experienced multiple TBIs. The link between TBI and gambling is also supported by recent neurological research [29] and animal research [30].…”

Section: Introductionmentioning

confidence: 82%

Traumatic brain injuries and problem gambling in youth: Evidence from a population-based study of secondary students in Ontario, Canada

et al. 2020

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Traumatic brain injury (TBI) is characterized by a change in brain function after an external force or sudden movement to the head. TBI is associated with risk-taking, impulsivity, psychological distress, substance abuse, and violent crime. Previous studies have also linked problem gambling to TBI, but these studies have not controlled for possible confounding variables such as mental health problems and hazardous drinking which are also linked to TBI. This study examines the relationship between problem gambling and TBI among adolescents. Data were obtained from the 2011, 2013 and 2015 cycles of the OSDUHS, a biennial cross-sectional school-based study of children in grades 7 to 12 (N = 9,198). Logistic regression was used to estimate adjusted odds ratios (AOR) in controlled and uncontrolled analyses. Adjusting for sex and grade only, problem gambling was associated with a history of TBI (AOR = 2.8). This association remained significant after adjusting for hazardous drinking and suicidality (AOR = 2.0). In addition, problem gambling had a statistically significant relationship with being male (AOR = 4.7), hazardous drinking (AOR = 4.5), and suicidality (AOR = 3.1). This study provides further data to suggest a link between TBI and problem gambling. However, research is needed on the causal relationship between these variables and the potential implications for treatment and prevention.

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Section: Introductionmentioning

confidence: 82%

Traumatic brain injuries and problem gambling in youth: Evidence from a population-based study of secondary students in Ontario, Canada

et al. 2020

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“…Our lab has demonstrated long-lasting deficits in attention, impulsivity, and risky decision-making in a rat model of TBI. 12,13 In the current study, we sought to determine whether tDCS stimulation could effectively treat chronic psychiatric-like symptoms such as impulsivity and attentional impairments after a brain injury in rats. The goal was to establish a model that could be used to further investigate treatment parameters and mechanisms of action for tDCS in recovery of cognitive function.…”

mentioning

confidence: 99%

Cathodal Transcranial Direct-Current Stimulation Selectively Decreases Impulsivity after Traumatic Brain Injury in Rats

Martens

Pechacek

Modrak

et al. 2019

Journal of Neurotrauma

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Traumatic brain injury (TBI) often results in chronic psychiatric-like symptoms. In a condition with few therapeutic options, neuromodulation has emerged as a promising potential treatment avenue for these individuals. The goal of the current study was to determine if transcranial direct-current stimulation (tDCS) could treat deficits of impulsivity and attention in rats. This could then be used as a model to investigate treatment parameters and the mechanism of action underlying therapeutic effects. Rats were trained on a task to measure attention and motor impulsivity (five-choice serial reaction time task), then given a frontal, controlled cortical impact injury. After rats recovered to a new baseline, tDCS (cathodal, 10 min, 800 lA) was delivered daily prior to testing in a counterbalanced, cross-over design. Treatment with tDCS selectively reduced impulsivity in the TBI group, and the greatest recovery occurred in the rats with the largest deficits. With these data, we have established a rat model for studying the effects of tDCS on psychiatric-like dysfunction. More research is needed to determine the mechanism of action by which tDCS-related gains occur.

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“…Healthy control rats choose the optimal option most frequently, followed by the riskier options (Zeeb & Winstanley, 2013), but TBI rats have persistent reductions in optimal choice for 12 weeks postinjury. Further, TBI increases risky choice and motor impulsivity (Shaver et al, 2019). Overall, the RGT appears to be an effective task for capturing chronic cognitive deficits following TBI in rats given that it encompasses both risky decision-making and motor impulsivity.…”

Section: Risky Decision-making In Preclinical Populationsmentioning

confidence: 95%

“…During the timeout, no responses were reinforced, and the light in the previouslychosen hole slowly flashed for the duration (1 Hz). A schematic of the task can be seen in Figure 2 (Shaver et al, 2019). The location of the P1, P2, P3, and P4 holes were counterbalanced across animals to account for potential side bias.…”

Section: Rodent Gambling Task Trainingmentioning

confidence: 99%

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The Role of High-Fat Diets in Exacerbating Cognitive Deficits After Traumatic Brain Injury

Frankot¹

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Traumatic brain injury (TBI) can cause chronic psychiatric-like impairments that may be driven by inflammation in the brain. In the current study, inflammation was upregulated using a high-fat diet (HFD) to assess the role of inflammation in TBI-induced deficits. Rats were randomly assigned to receive an HFD or calorie-matched low-fat diet (LFD) for the duration of the experiment. After two weeks of free access to their respective diets, rats began behavioral training on the Rodent Gambling Task (RGT), during which they were allowed to freely choose to nosepoke in one of four holes in a standard operant chamber. Responses in each hole were associated with different probabilities and magnitudes of reinforcement (sucrose pellets) or punishment (timeout from reinforcement); thus, choices could be classified as either risky or optimal. Premature responses (i.e., nosepokes made before the trial began) were used as a measure of motor impulsivity. After behavior on the RGT stabilized, rats received either a frontal TBI or a sham procedure and continued post-injury testing for 10 weeks. TBI rats substantially decreased in optimal choice but increased in risky choices and motor impulsivity. However, deficits induced or exacerbated by the HFD were inconsistent and low in magnitude. After the behavioral portion of the study, rats were transcardially perfused. The HFD and TBI in combination interacted to increase neuroinflammation, as measured by microglia count. Increases in microglia unaccompanied by changes in behavior indicated that inflammation may simply be a symptom of brain injury and not a driver of psychiatric-like deficits. Thus, further evidence is required to characterize the role of inflammation in cognitive impairment both within and outside the context of brain injury.

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Long-term deficits in risky decision-making after traumatic brain injury on a rat analog of the Iowa gambling task

Cited by 29 publications

References 66 publications

Traumatic brain injuries and problem gambling in youth: Evidence from a population-based study of secondary students in Ontario, Canada

Traumatic brain injuries and problem gambling in youth: Evidence from a population-based study of secondary students in Ontario, Canada

Cathodal Transcranial Direct-Current Stimulation Selectively Decreases Impulsivity after Traumatic Brain Injury in Rats

The Role of High-Fat Diets in Exacerbating Cognitive Deficits After Traumatic Brain Injury

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