Long-Term Cryopreservation May Cause Genomic Instability and the Premature Senescence of Cells
Mariia Shorokhova,
Natalia Pugovkina,
Victoria Zemelko
et al.
Abstract:Cryopreservation is an essential step for utilizing various cell types for biological research and medical purposes. At the same time, there is a lack of data on the effect of cryopreservation, especially when prolonged, on the karyotype of cells. In the present work, we analyzed the genetic stability of cells subjected to a cryopreservation procedure. The objects were immortalized Chinese hamster lung fibroblasts (CHL V-79 RJK line) and human endometrial mesenchymal stem/stromal cells (eMSCs). We showed that … Show more
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