Long-term course of Menière's disease revisited

Huppert, Doreen; Strupp, Michael; Brandt, Thomas

doi:10.3109/00016480903382808

Cited by 172 publications

(147 citation statements)

References 48 publications

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“…This shared aetiology between Meniere's disease and motion sickness may thus exaggerate sensory conflict during provocative motion stimuli. Bilateral Meniere's disease participants had higher levels of disease activity than unilateral, as indicated by increased numbers of vertigo attacks (Table 3), although others have found no difference [19,20]. We found that bilateral sufferers had higher motion sickness susceptibility than unilateral sufferers (MSC scores).…”

Section: Discussionsupporting

confidence: 52%

Meniere’s, migraine, and motion sickness

Golding

Patel

2016

Acta Oto-Laryngologica

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METHODSWe conducted an online survey that posed diagnostic and disease questions before addressing frequency of headaches, migraines, visual display dizziness (VDD), syncope, social life and work impact of dizziness (SWID4) and motion sickness susceptibility (MSSQ). The two groups were: diagnosed MD individuals with hearing loss (n=751) and non-MD individuals in the control group (n=400). RESULTSThe MD group showed significantly elevated MSS, more headache and migraine, increased VDD, higher SWID4 scores, and increased syncope. MSS was higher in MD than controls only after the development of MD but not before, nor in childhood. Although elevated in MD compared with controls, MSS was lower than migraine patients from past data.Multivariate analysis revealed VDD, SWID4 and MSS in adulthood as the strongest predictors of MD, but not headache nor migraine.

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Section: Discussionsupporting

confidence: 52%

Meniere’s, migraine, and motion sickness

Golding

Patel

2016

Acta Oto-Laryngologica

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“…While the age of our patients were similar to elsewhere, we observed a male preponderance which is different from the equal male:female ratio [4] shown in the world literature. However a few reports have also shown a [6,3,7], female preponderance. Our findings could be because the male/female attendance in our audio vestibular clinic also has a male preponderance (2:1) and more men in India seek medical attention than women.…”

Section: Discussionmentioning

confidence: 98%

“…In world literature, the frequency of MD varies widely, with incidence ranging from 10 to 157 [2,3] per 100,000 in developed countries. The present study found that the frequency of MD in a tertiary level hospital is about 15.6%.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Audio Vestibular Profile of Meniere’s Disease in a Tertiary Care Centre in India

Selvakumar

Balraj

Kurien

et al. 2011

Indian J Otolaryngol Head Neck Surg

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The aims of this study are to determine the frequency of patients presenting with Meniere's Disease(MD) in an Indian setting, using the American Academy of Otolaryngology-Head and Neck Surgery (AAO) diagnostic criteria, and to describe the clinical and audio vestibular profiles of these patients. The study was based on prospective case series design in the settings of a tertiary referral hospital. The study included all consecutive patients aged between 5 and 75 years presenting with the history of hearing loss, vertigo, tinnitus and or aural fullness as participants, satisfying inclusion and exclusion criteria for MD (AAO 1995) recruited over a 12 month period. Main outcome measures comprised the evaluation of epidemiological profile, clinical features, and results of audio vestibular investigations like Pure Tone Audiometry with and without glycerol, Impedance Audiometry, Electrocochleography (ECohG), Distortion Product Otoacoustic Emission and Electronystagmography (ENG). The results of the study are as follows: The frequency of MD was 15.6%, being commoner in males than females (2.6:1) and occurring more in the age group 40-49 years among males and 30-39 years among females. High frequency tinnitus was commoner than low frequency tinnitus. Extra tympanic ECohG had a positive predictive value of 76% for endolymphatic hydrops. ENG was useful for demonstrating canal paresis pattern of nystagmus in 61%. Indian patients with MD commonly present to tertiary care at the functional level scale of 3. The results of this study revealed that the frequency of MD is not as low in the Indian ENT setting as earlier believed. There is a high chance of missing cases in the routine ENT outpatient clinic setting unless a structured proforma incorporating the AAO 1995 diagnostic criteria is used.

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“…Among his many research accomplishments was the development of tests to detect vestibular dysfunction, which currently affects tens of millions of people in the USA alone (Neuhauser and Lempert, 2009). Vestibular disorders range from bouts of vertigo that may last for minutes, to the chronic and debilitating effects of Ménière's disease, which in extreme cases results in balance and hearing impairment for life (Marom et al, 2009;Huppert et al, 2010). Most vestibular disorders are idiopathic in origin; however, in a subset of cases there is a clear developmental basis to the defect.…”

Section: Introductionmentioning

confidence: 99%

Divergent roles for Wnt/β-catenin signaling in epithelial maintenance and breakdown during semicircular canal formation

Rakowiecki

Epstein

2013

Development

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SUMMARYThe morphogenetic program that shapes the three semicircular canals (SSCs) must be executed with extreme precision to satisfy their complex vestibular function. The SSCs emerge from epithelial outgrowths of the dorsal otocyst, the central regions of which fuse and resorb to leave three fluid-filled canals. The Wnt/β-catenin signaling pathway is active at multiple stages of otic development, including during vestibular morphogenesis. How Wnt/β-catenin functionally integrates with other signaling pathways to sculpt the SSCs and their sensory patches is unknown. We used a genetic strategy to spatiotemporally modulate canonical Wnt signaling activity during SSC development in mice. Our findings demonstrate that Wnt/β-catenin signaling functions in a multifaceted manner during SSC formation. In the early phase, Wnt/β-catenin signaling is required to preserve the epithelial integrity of the vertical canal pouch perimeter (presumptive anterior and posterior SSCs) by establishing a sensory-dependent signaling relay that maintains expression of Dlx5 and opposes expression of the fusion plate marker netrin 1. Without this Wnt signaling activity the sensory to non-sensory signaling cascade fails to be activated, resulting in loss of vestibular hair and support cells and the anterior and posterior SSCs. In the later phase, Wnt/β-catenin signaling becomes restricted to the fusion plate where it facilitates the timely resorption of this tissue. Mosaic recombination of β-catenin in small clusters of canal pouch cells prevents their resorption, causing instead the formation of ectopic SSCs. Together, these disparate functions of the Wnt/β-catenin pathway in epithelial maintenance and resorption help regulate the size, shape and number of SSCs.

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Long-term course of Menière's disease revisited

Cited by 172 publications

References 48 publications

Meniere’s, migraine, and motion sickness

Meniere’s, migraine, and motion sickness

Clinical and Audio Vestibular Profile of Meniere’s Disease in a Tertiary Care Centre in India

Divergent roles for Wnt/β-catenin signaling in epithelial maintenance and breakdown during semicircular canal formation

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