Long-term cost-effectiveness of clopidogrel given for up to one year in patients with acute coronary syndromes without ST-segment elevation

Abstract

Platelet inhibition with clopidogrel in patients for up to one year after presentation with an acute coronary syndrome is both effective and cost-effective.

Primary and Secondary Prevention of Cardiovascular Disease

“…Resource Considerations-Six studies 33,[49][50][51][52][53] examined the cost-effectiveness of combined antiplatelet therapy with clopidogrel plus aspirin vs aspirin alone in patients after a recent ACS. These studies are consistent in demonstrating the cost-effectiveness of combined antiplatelet therapy with clopidogrel plus aspirin compared with aspirin alone after ACS.…”

Pharmacoeconomic Analysis of Clopidogrel in Secondary Prevention of Coronary Artery Disease

“…Costs were derived from average wholesale drug cost in the United States and from Medicare reimbursement. 28 The ICER reported in this analysis was $6,318 per life-year gained with clopidogrel, with 94% of bootstrap-derived ICER estimates of <$50,000 (the U.S. threshold of cost-effectiveness) per lifeyear gained. It is, however, important to realize that there were only 500 patients from the United States out of approximately 12,000 patients enrolled in CURE.…”

“…The availability of numerous large, randomized, controlled studies of clopidogrel efficacy allows pharmacoeconomic evaluations to be performed in different patient populations, using the data from health care resources consumed (e.g., number of hospitalizations, amount of outpatient care consumed, and medication cost). [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] This article reviews previously published pharmacoeconomic analyses on the use of clopidogrel in patients with known CAD. These analyses include the use of clopidogrel for secondary prevention of CV events in patients with ACS and in those undergoing PCI.…”

Compilation of cost-effectiveness evidence for different heart conditions and treatment strategies

“…A scatterplot diagram is a simple solution to illustrate the uncertainty in the results of cost-effectiveness analyses. Stochastic rankings have also been proposed to be used in a budgetary context [14][15][16][17][18].…”