Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain

Mao, Jianhua; Wang, Yun; Zhang, Wei; Shen, Yan; Zhang, Guowei; Xi, Wenda; Wang, Qiang; Ruan, Zheng; Wang, Jin; Xi, Xiaodong

doi:10.1007/s11684-021-0844-7

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Regional Hydrodynamic Delivery1

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2023

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“…It was reported that cavitation prolongs transgene expression when coupled with hydrodynamic force [178]. Similarly, various nonviral and viral vectors, such as polyplexes [57,62,217], cationic liposomes [135], adenoassociated virus [86,103,[220][221][222][223], lentivirus [38,224,225], and foamy virus [34], have been administered under hydrodynamic conditions to achieve improved gene transfer.…”

Section: Regional Hydrodynamic Deliverymentioning

confidence: 99%

Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances

et al. 2023

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The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery.

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