Paget's disease is a common focal skeletal disorder that is characterized by excessive breakdown and formation of bone tissue and is associated with morphologic and functional abnormalities of osteoclasts. The aim of treatment is to suppress the osteoclast activity. Bisphosphonates are the first-choice agents used for treatment of Paget's disease. Zoledronic acid is a new member of bisphosphonates. We reported a patient diagnosed with Paget's disease who had been treated with 5 mg zoledronic acid infusion and the laboratory and clinical results. We also reported the adverse events associated with zoledronic acid infusion therapy. The clinical and laboratory response had been achieved in the course of 2 weeks. The adverse events associated with zoledronic acid administration were fever, arthralgia, myalgia, and asymptomatic hypocalcemia. At the follow-up examination at the sixth month, the patient was still asymptomatic, and serum alkaline phosphatase and calcium levels were in the normal range. In conclusion, zoledronic acid is effective in Paget's disease treatment. Although it is known that zoledronic acid is safe and well tolerated, the physician must be aware of adverse events, especially in elderly patients.