Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study

Brink, Elizabeth J.; Coxam, Véronique; Robins, Simon P.; Wähälä, Kristiina; Cassidy, Aedín; Branca, Francesco

doi:10.1093/ajcn/87.3.761

Cited by 127 publications

(105 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the mechanisms by which these benefits are effected are unknown-benefits, however, have been debated, as demonstrated by the controversial effects of isoflavone on bone density in postmenopausal women (Ma et al 2008;Brink et al 2008;Alekel et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

Hong

Ahn

et al. 2012

Genes Nutr

View full text Add to dashboard Cite

Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equol production on health in Koreans and identified the genetic factors that determine the equol-producing phenotype. In 1391 subjects, the equol-producing phenotype was determined, based on measurements of serum equol concentrations. The anthropometric and blood biochemical measurements between equol producers and nonproducers were analyzed by LC-MS/MS. Genetic factors were identified in a genomewide association study (GWAS), and the interaction between genetic factors and the equol-producing phenotype was examined. We observed that 70.1 % of the study population produced equol. Blood pressure was significantly lower in equol producers (beta ± SE = -1.35 ± 0.67, p = 0.045). In our genomewide association study, we identified 5 single-nucleotide polymorphisms (p \ 1 9 10 -5 ) in HACE1. The most significant SNP was rs6927608, and individuals with a minor allele of rs6927608 did not produce equol (odds ratio = 0.57 (95 % CI 0.45-0.72), p value = 2.5 9 10 -6 ). Notably, the interaction between equol production and the rs6927608 HACE1 SNP was significantly associated with systolic blood pressure (p value = 1.3 9 10 4 ). Equol production is linked to blood pressure, and HACE1, identified in our (GWAS), might be a determinant of the equol-producing phenotype.

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

Hong

Ahn

et al. 2012

Genes Nutr

View full text Add to dashboard Cite

show abstract

“…Soy isoflavones were shown to attenuate bone loss from the lumbar spine in perimenopausal women, 4 possibly by stimulating bone formation 4,30 or inhibiting bone resorption. 30,31 Other studies, however, have not substantiated these beneficial effects on bone mineral density (BMD) 32,33 or biochemical markers of bone. 33 The effect of soy consumption on thyroid status is also of interest because four decades ago, goiter was reported in infants fed soy formula that was not fortified with iodine.…”

mentioning

confidence: 99%

“…30,31 Other studies, however, have not substantiated these beneficial effects on bone mineral density (BMD) 32,33 or biochemical markers of bone. 33 The effect of soy consumption on thyroid status is also of interest because four decades ago, goiter was reported in infants fed soy formula that was not fortified with iodine. [34][35][36] Perhaps soy isoflavones may impair thyroid hormone synthesis when iodide intake is inadequate.…”

mentioning

confidence: 99%

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

Background: Soy foods have been substituted for meat in recent years because of proposed health benefits. Research indicates, however, that soy protein and phytate in soy products inhibit the absorption of divalent cations. Methods: Our study was primarily designed to determine the effect of consuming two to three servings per day of soy foods, providing *19 g protein and *36 mg isoflavones, on iron and zinc status in premenopausal women during a 10-weeks period. As secondary outcomes, we also tested the effect of soy foods on biochemical markers of bone and thyroid hormones. Nonsmoking women (18-28 years) without chronic disease, anemia, pregnancy, or irregular menstrual cycles were randomly assigned to either the soy food (SF, n = 31) or animal food (AF, n = 32) group. Blood and urine samples and 3-day dietary records were collected at baseline and postintervention. Results: At baseline, iron and zinc status, bone markers, and thyroid hormones were not different between groups. After intervention, no significant changes were observed in hemoglobin, transferrin saturation, serum iron, ferritin, or transferrin receptor (TFR) concentrations. Plasma zinc, but not serum alkaline phosphatase, significantly decreased in both groups ( -0.8 lmol/L).

show abstract

“…That is, the odds ratio adjusted according to the ER· polymorphism showed that equol producers with the pp allele group had a decreased risk of OSI reduction. Not only did dietary equol administration to ovariectomized rats show limited bone sparing effects (12), but also long-term consumption of isoflavone-enriched foods did not affect bone metabolism in early postmenopausal women (28). However, these reports did not take ER· polymorphism into account.…”

Section: Discussionmentioning

confidence: 97%

Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass

Katsuyama

Arii²,

Tomita³

et al. 2009

Int J Mol Med

View full text Add to dashboard Cite

Abstract. To investigate the relationship between estrogen receptor polymorphisms and equol production and its effect on bone turnover, 139 workers (mean age 38.3±11.1 years) in Japan were recruited. Bone mineral density (BMD), bone turnover markers, and serum equol were measured at a health examination. DNA samples were prepared to detect the estrogen receptor · (ER·) polymorphism and were digested by PvuII. The number of equol producers was 57. No statistically significant differences were observed in bone mineral density and bone turnover markers between each ER· polymorphism and equol production. Since the adjusted odds ratio indicated that interaction itself decreased the risk of osteosonoassessment index (OSI) reduction using logistic regression analysis, further analysis was performed divided by each ER· polymorphism. Although the crude odds ratio showed no relationship between equol producers and non-producers, the adjusted odds ratio showed that equol producers with ER· pp had a significantly decreased risk of OSI reduction. Although this study was cross-sectional, both equol production and ER· polymorphism are closely associated with each other in relation to BMD.

show abstract

Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study

Abstract: Consumption of foods containing 110 mg/d of soy isoflavone aglycone equivalents for 1 y did not prevent postmenopausal bone loss and did not affect bone turnover in apparently healthy early postmenopausal white women. This trial was registered at clinicaltrials.gov as NCT00301353.

Cited by 127 publications

References 32 publications

Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Association between estrogen receptor α polymorphisms and equol production, and its relation to bone mass

Contact Info

Product

Resources

About