Long-term Consumption of Capsicum annuum (Chili Pepper) and Capsaicin Diets Elevates Anxiety but Improves Motor Coordination in CD-1 Mice

Nmaju, A; Joshua, I; Okon, Udemeobong; Bisong, Sunday Agba; Nwankwo, Azubuike; Osim, E. E.

doi:10.9734/jammr/2018/40348

Cited by 1 publication

(3 citation statements)

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“…On the other hand, the head dips and stretch attend postures of the capsaicin group was significantly higher than the control. These results showed that both pepper and capsaicin increased anxiety in the mice, but the anxiogenic effects of capsaicin were greater [26].…”

Section: Anxietymentioning

confidence: 86%

“…Capsaicin and pepper-diet fed mice had significantly reduced foot slips and falls compared to control and these typify improvement in their motor coordination because the lower the frequency of foot slips and number of falls, the better coordinated the animal was [26]. Capsaicin, as the most abundant and commonly occurring capsaicinoid might have achieved this feat (improvement of motor coordination) by aiding in the integration of proprioceptive information with neural processes (TRPV1) in the spinal cord and in the brain (specifically cerebellum) [31].…”

Section: Motor Coordinationmentioning

confidence: 98%

“…Following the consumption of pepper and capsaicin diets, the pepper and capsaicin groups had lower open arm entry frequency and duration in the elevated plus maze test. Since fearful mice tend to avoid open areas (especially when they are brightly lit), favouring darker and more enclosed spaces [25], these results imply that chilli pepper and capsaicin caused increase in anxiety in the mice [26].…”

Section: Anxietymentioning

confidence: 99%

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The Effects of Consumption of Capsicum on Some Neurobehavioural Parameters

Osim¹,

Nmaju²,

Nwankwo³

et al. 2020

Capsicum

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Capsicum annum, an extensively cultivated vegetable, is commonly used to spice many dishes prepared in several parts of the world. It contains capsaicinoids, which give it a characteristic pungency. The most active and well known amongst these capsaicinoids is capsaicin (8-methyl-N-vanillyl-6-nonenamide), which is neurogenic and may affect neuronal functions. Therefore, our study investigated the effects of consumption of chilli pepper and capsaicin diets on neurobehaviour of CD-1 mice. The neurobehavioural parameters assessed were anxiety, motor coordination, pain, social behaviour, learning and memory. The animals were randomly assigned into three groups of 10 mice each, namely, control, pepper-diet (20% w/w), and capsaicin-diet (10% w/w) groups. Their learning and memory abilities were assessed through their ability to locate the hidden platform model of Morris water maze apparatus. The elevated plus maze and light-dark transition box were used to assess anxiety-related behaviour, while the beam walking test and nesting behaviour were used to determine motor coordination and social behaviour, respectively. Tail immersion, hot plate, and formalin tests were conducted to assess pain perception. Consumption of the chilli pepper and capsaicin diets decreased pain perception, increased anxiety, and impaired learning and memory but enhanced social behaviour and motor coordination in mice.

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Section: Anxietymentioning

confidence: 86%

Section: Motor Coordinationmentioning

confidence: 98%

Section: Anxietymentioning

confidence: 99%

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