“…• Introduction of extended-field high-dose (35)(36)(37)(38)(39)(40)(41)(42)(43)(44) The types of chemotherapy-induced cardiovascular alterations reported primarily, but not exclusively, in adults include the following: Acute cardiac rhythm abnormalities (arrhythmias including QT prolongation), myocardial ischemia or infarction, hypertension, and significant left ventricular (LV) contractile dysfunction. 37,38 The pathogenesis of these diverse cardiovascular effects varies and may involve multiple mechanisms.…”