Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review

Handel, M; Swaab, Hanna; Vries, Linda S. de; Jongmans, Marian J.

doi:10.1007/s00431-007-0437-8

Cited by 300 publications

(231 citation statements)

References 63 publications

Supporting

Mentioning

213

Contrasting

Unclassified

Order By: Relevance

“…Little is known about the long-term outcome of children with NE (3)(4)(5)(6). In this study, 21 children (33.3%) with NE had an abnormal outcome on the M-ABC (Յ5th percentile) and 18 (28.6%) had a TIS between the 6th and 15th percentile.…”

Section: Van Kooij Et Almentioning

confidence: 81%

“…Long-term follow-up data of neurodevelopmental outcome are still scarce but have shown significantly more problems at school age in children with moderate NE (NE II) according to the criteria of Sarnat (2) compared with children with mild NE according to the criteria of Sarnat (NE I) and matched controls (3)(4)(5)(6). Magnetic resonance imaging (MRI) studies have made a major contribution to recognize the different patterns of NErelated cerebral lesions, which have been shown to be predictive of long-term neurodevelopmental outcome (7)(8)(9)(10).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Corpus Callosum Size in Relation to Motor Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy

et al. 2008

Self Cite

View full text Add to dashboard Cite

ABSTRACT:Magnetic resonance imaging studies have contributed to recognize the patterns of cerebral injury related to neonatal encephalopathy (NE). We assessed whether a smaller corpus callosum (CC) explained the difference in motor performance between school-age children with NE and controls. Frontal, middle, and posterior areas of the CC were measured in 61 9 -10-y-old children with NE and in 47 controls. Motor performance was determined using the Movement Assessment Battery for Children (M-ABC). Linear regression was used to assess whether differences in M-ABC between NE children and controls could be explained by CC size. The CC of 11/30 children with NE type I according to Sarnat (NE I) and 19/36 children with NE type II according to Sarnat (NE II) showed generalized or focal thinning, compared with 8/49 controls. Children with NE II had significantly smaller middle and posterior parts and total areas of the CC. Children with NE scored significantly worse on the M-ABC than controls. The reduction in size of the posterior part of the CC partly explained the mean differences on the M-ABC. Children with NE have poorer motor skills than controls, which is partly explained by a smaller size of the CC. N eonatal encephalopathy (NE) related to perinatal asphyxia has a prevalence of 1-6/1000 live-born, full-term infants (1). Long-term follow-up data of neurodevelopmental outcome are still scarce but have shown significantly more problems at school age in children with moderate NE (NE II) according to the criteria of Sarnat (2) compared with children with mild NE according to the criteria of Sarnat (NE I) and matched controls (3-6). Magnetic resonance imaging (MRI) studies have made a major contribution to recognize the different patterns of NErelated cerebral lesions, which have been shown to be predictive of long-term neurodevelopmental outcome (7-10).The corpus callosum (CC) links associative areas of the two cerebral hemispheres. The genu of the CC is formed between 8 and 13 wk of gestation. After 20 wk gestational age the total CC is formed (11). The CC is among the last structures to be completed during postnatal maturation. Its size increases with age until early adulthood because of the ongoing myelinization process, which begins to appear at about 4 mo of age in the splenium and at 6 mo in the genu (12,13). Due to its longer myelogenetic cycle, the CC is vulnerable to hemorrhage and ischemia (14). Fibers from the frontal lobe and the anterior part of the parietal lobe course through the rostrum and genu of the CC. Fibers from the temporal, posterior part of the parietal and occipital lobe are carried in the caudal portion of the body of the CC and in the splenium (14,15).Several studies have shown a relation between the CC size and motor outcome in preterm infants (16 -18). Maneru et al. (19) demonstrated that the CC was smaller in adolescents who suffered from moderate asphyxia than in controls. The CC measurements correlated with neuropsychological performance.In the present study, we assessed the differ...

show abstract

Section: Van Kooij Et Almentioning

confidence: 81%

mentioning

confidence: 99%

Corpus Callosum Size in Relation to Motor Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of neurodevelopment morbidity and of mortality in term and preterm infants with an estimated 1.2 million deaths every year worldwide (1)(2)(3). Newborns with asphyxia and HIE often suffer multiple organ failure as a result of the hypoxic-ischemic insult, including myocardial dysfunction (4).…”

Section: Introductionmentioning

confidence: 99%

Preferential Cephalic Redistribution of Left Ventricular Cardiac Output during Therapeutic Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy

Hochwald

Jabr

Osiovich

et al. 2014

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective-To determine the relationship between left ventricular cardiac output (LVCO), superior vena cava (SVC) flow, and brain injury during whole-body therapeutic hypothermia.Study design-Sixteen newborns with moderate or severe hypoxic-ischemic encephalopathy were studied using echocardiography during and immediately after therapeutic hypothermia. Measures were also compared with 12 healthy newborns of similar postnatal age. Newborns undergoing therapeutic hypothermia also had a cerebral magnetic resonance imaging as part of routine clinical care on postnatal day 3-4.Results-LVCO was markedly reduced (mean+/−SD: 126+/−38 mL/kg/min) during therapeutic hypothermia, whereas SVC flow was maintained within expected normal values (88+/− 27 mL/kg/ min) such that it represented 70% of the LVCO. The reduction in LVCO during therapeutic hypothermia was mainly accounted by a reduction in heart rate (99 +/− 13 BPM versus 123 +/− 17 BPM; p<0.001) compared to immediately post-warming, in the context of myocardial dysfunction. Neonates with documented brain injury on MRI showed higher SVC flow pre-rewarming, compared to newborns without brain injury (p=0.013).Conclusion-Newborns with perinatal hypoxic-ischemic encephalopathy showed a preferential systemic-to cerebral redistribution of cardiac blood flow during whole-body therapeutic hypothermia, which may reflect a lack of cerebral vascular adaptation in newborns with more severe brain injury.

show abstract

“…B rain injury in humans, which occurs as a result of an hypoxic-ischemic (HI) episode during the perinatal period, is a major cause of mortality and long-term disability (1). Although there is now a greater understanding of the mechanisms involved in cell death processes associated with HI injury (2), there are still no beneficial therapeutic interventions.…”

mentioning

confidence: 99%

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

et al. 2008

View full text Add to dashboard Cite

ABSTRACT:Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl 2 ) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain. We examined long-term functional and protective actions of preconditioning induced by hypoxia, CoCl 2 and DFX in a neonatal rat model of HI. Postnatal day six rat pups were exposed to preconditioning with hypoxia (8% oxygen) or injections of CoCl 2 , DFX or saline vehicle and 24 h later rats underwent HI or sham surgery. Behavioral tests were performed and at the conclusion of experiments, brains removed for morphologic analyses. HI resulted in a large unilateral lesion in the ipsilateral hemisphere compared with sham control rats. All preconditioning treatments significantly reduced the total lesion volume. Behavioral deficits were observed in HI rats compared with sham controls. The reduction in forelimb grasping strength in HI rats was attenuated by preconditioning with hypoxia, CoCl 2 and DFX. HI increased the number of foot faults in a grid-walking test and resulted in forelimb asymmetry in the cylinder test. Only preconditioning with hypoxia reversed all three functional deficits after HI. These findings indicate that preconditioning, especially when induced by hypoxia, has the potential to minimize the morphologic and functional effects of neonatal HI injury. (Pediatr Res 63: 620-624, 2008)

show abstract

Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review

Cited by 300 publications

References 63 publications

Corpus Callosum Size in Relation to Motor Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy

Corpus Callosum Size in Relation to Motor Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy

Preferential Cephalic Redistribution of Left Ventricular Cardiac Output during Therapeutic Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Contact Info

Product

Resources

About