Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty

Aulakh, Tajeshwar S.; Jayasekera, Narlaka; Kuiper, Jan-Herman; Richardson, James B.

doi:10.1016/j.biomaterials.2008.12.035

Cited by 46 publications

(32 citation statements)

References 34 publications

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“…1 Currently, nanotechnology has entered the field of biomaterials, resulting in the rapid development of nano-based HA. Due to their better bioactivity, their excellent capacity to penetrate cell membranes, and their increased circulation time, HA nanoparticles (HANPs) have gradually garnered significant interest in various medical fields, such as bone tissue engineering, cardiovascular graft coating, contrast agent synthesis, drug delivery, and gene therapy.…”

Section: Introductionmentioning

confidence: 99%

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte–endothelial cell coculture model

Liu¹,

Sun²

2014

IJN

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Currently, synthetic hydroxyapatite nanoparticles (HANPs) are used in nanomedicine fields. The delivery of nanomedicine to the bloodstream exposes the cardiovascular system to a potential threat. However, the possible adverse cardiovascular effects of HANPs remain unclear. Current observations using coculture models of endothelial cells and monocytes with HANPs to mimic the complex physiological functionality of the vascular system demonstrate that monocytes could play an important role in the mechanisms of endothelium dysfunction induced by the exposure to HANPs. Our transmission electron microscopy analysis revealed that both monocytes and endothelial cells could take up HANPs. Moreover, our findings demonstrated that at a subcytotoxic dose, HANPs alone did not cause direct endothelial cell injury, but they did induce an indirect activation of endothelial cells, resulting in increased interleukin-6 production and elevated adhesion molecule expression after coculture with monocytes. The potential proinflammatory effect of HANPs is largely mediated by the release of soluble factors from the activated monocytes, leading to an inflammatory response of the endothelium, which is possibly dependent on p38/c-Jun N-terminal kinase, and nuclear factor-kappa B signaling activation. The use of in vitro monocyte–endothelial cell coculture models for the biocompatibility assessment of HANPs could reveal their potential proinflammatory effects on endothelial cells, suggesting that exposure to HANPs possibly increases the risk of cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte–endothelial cell coculture model

Liu¹,

Sun²

2014

IJN

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“…Radiolucencies around the acetabular component on the latest follow-up radiograph were assessed according to the method of DeLee and Charnley (1976). The presence or absence of graft incorporation in each of these zones was recorded according to the system described by the Oswestry group (Aulakh et al 2009). Components were considered to have migrated if they had moved by 3 mm or more from the inter-tear drop line or trans-ischial line where this was obscured (Ritter et al 1999).…”

Section: Methodsmentioning

confidence: 99%

Impaction grafting of the acetabulum with ceramic bone graft substitute

et al. 2013

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Background and purpose Loss of bone stock remains a challenge in revision hip surgery. Grafting with allograft is well established, but there are problems with availability, cost, infection, antigenicity, reproducibility, and stability of the created construct. BoneSave is a biphasic porous ceramic consisting of sintered 80% tricalcium phosphate and 20% hydroxyapatite. In vitro and in vivo studies, including its use mixed with allograft, have shown good results in impaction grafting. This is the first reported series of its use alone in impaction grafting of the acetabulum.Methods Methods We conducted a retrospective review of a cohort of 43 consecutive patients undergoing impaction grafting of contained acetabular defects by multiple surgeons at a single centre. All patients received uncemented acetabular components. They were followed up radiographically, together with self-reported satisfaction scale (SAPS), Oxford hip score (OHS), and Short-Form 12 (SF12) health survey. Kaplan-Meier survivorship analysis was performed with revision of the acetabular component, revision of any part of the construct, and reoperation as endpoints.Results The fate of all cases was known. Mean follow-up was 4 years. 5 patients died during follow-up, with their constructs in situ. The survivorship of the acetabular component was 98% (95% CI: 85–100) at 7 years. 1 acetabular component was revised for infection and there was 1 radiographic acetabular failure. The median OHS was 36 (6–48), the median SF12 PCS was 36 (14–57), the median SAPS was 75 (0–100), and the median SF12 MCS was 50 (23–64). The graft material had incorporated in all 3 zones of the acetabulum in 33 out of 37 cases with complete radiographic follow-up.Interpretation Medium-term results show that BoneSave alone is a reliable material for impaction grafting of contained defects in the acetabulum at revision surgery.

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“…The clinical outcomes of impaction allografting using a composite of allograft with HA have been shown to be good at 13 years postoperatively [92], and initial reports of the addition of concentrated BMA to allograft scaffolding in revision arthroplasty have been promising. In a prospective study of five patients undergoing impaction allografting of acetabular defects in revision arthroplasty, Vulcano et al [93] reported that four of five patients had healed clinically and radiologically in 3.5 months with no adverse effects, with one patient failing to respond [93].…”

Section: Use In Arthroplasty Surgerymentioning

confidence: 99%

Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data

Gamie

Macfarlane

Tomkinson

et al. 2014

Expert Opinion on Biological Therapy

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Enhanced results have been found when combining bone marrow-derived mesenchymal stem cells (BMMSCs) with recently developed scaffolds such as glass ceramics and starch-based polymeric scaffolds. Preclinical studies investigating adipose tissue-derived stem cells and umbilical cord tissue-derived stem cells suggest that they are likely to become promising alternatives. Stem cells derived from periosteum and dental tissues such as the periodontal ligament have an osteogenic potential similar to BMMSCs. Stem cells from human fetal bone marrow have demonstrated superior proliferation and osteogenic differentiation than perinatal and postnatal tissues. Despite ethical concerns and potential for teratoma formation, developments have also been made for the use of ESCs in terms of culture and ideal scaffold.

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Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty

Cited by 46 publications

References 34 publications

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte–endothelial cell coculture model

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte–endothelial cell coculture model

Impaction grafting of the acetabulum with ceramic bone graft substitute

Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data

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Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty

Cited by 46 publications

References 34 publications

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte&ndash;endothelial cell coculture model

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte&ndash;endothelial cell coculture model

Impaction grafting of the acetabulum with ceramic bone graft substitute

Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data

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Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte–endothelial cell coculture model

Potential proinflammatory effects of hydroxyapatite nanoparticles on endothelial cells in a monocyte–endothelial cell coculture model