Long-Term Clinical Outcome of First Recurrence Skull Base Meningiomas

Kuranari, Yuki; Tamura, Ryota; Tsuda, Noboru; Kosugi, Kenzo; Morimoto, Yukina; Yoshida, Kazunari; Toda, Masahiro

doi:10.3390/jcm9010106

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…Postoperative MRI was performed every 6-12 months. Tumor recurrence was defined as follows: 1) for patients with GTR, the appearance of new lesions at the prior surgical site and 2) for patients with STR, residual tumor growth (> 2 mm/ year) (19).…”

Section: Study Population and Clinical Datamentioning

confidence: 99%

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

et al. 2020

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BackgroundMeningiomas are the most common benign intracranial tumors. However, even WHO grade I meningiomas occasionally show local tumor recurrence. Prognostic factors for meningiomas have not been fully established. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic factor for several solid tumors. The prognostic value of NLR in meningiomas has been analyzed in few studies.Materials and MethodsThis retrospective study included 160 patients who underwent surgery for meningiomas between October 2010 and September 2017. We analyzed the associations between patients’ clinical data (sex, age, primary/recurrent, WHO grade, extent of removal, tumor location, peritumoral brain edema, and preoperative laboratory data) and clinical outcomes, including recurrence and progression-free survival (PFS).ResultsForty-four meningiomas recurred within the follow-up period of 3.8 years. WHO grade II, III, subtotal removal, history of recurrence, Ki-67 labeling index ≥3.0, and preoperative NLR value ≥2.6 were significantly associated with shorter PFS (P < 0.001, < 0.001, 0.002, < 0.001, and 0.015, respectively). Furthermore, NLR ≥ 2.6 was also significantly associated with shorter PFS in a subgroup analysis of WHO grade I meningiomas (P = 0.003). In univariate and multivariate analyses, NLR ≥2.6 remained as a significant predictive factor for shorter PFS in patients with meningioma (P = 0.014).ConclusionsNLR may be a cost-effective and novel preoperatively usable biomarker in patients with meningiomas.

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Section: Study Population and Clinical Datamentioning

confidence: 99%

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

et al. 2020

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“…For example, Da Broi et al [ 28 ] showed that in subtotally resected WHO grade 1 SBMs, re-treatment rate may rise up to 16%, 27%, 34%, and 38% at 1, 3, 5, and 10-years follow-up, illustrating how frequently recurrences are encountered after surgery [ 28 ]. Besides, Kuranari et al [ 75 ] assessed the predictors of shorter PFS in SBMS after initial surgical management: the 2-, 5-, and 10-year PFS rates were 68%, 53%, and 23%, respectively. The authors showed that higher WHO grades, multiple lesions, and tumor size were associated with shorter PFS, while postoperative radiotherapy improved PFS in patients with WHO grade 2 lesions after initial subtotal resection.…”

Section: Discussionmentioning

confidence: 99%

Management of Recurrent Meningiomas: State of the Art and Perspectives

Corniola

Meling

2022

Cancers

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Background: While meningiomas often recur over time, the natural history of repeated recurrences and their management are not well described. Should recurrence occur, repeat surgery and/or use of adjuvant therapeutic options may be necessary. Here, we summarize current practice when it comes to meningioma recurrence after initial surgical management. Methods: A total of N = 89 articles were screened. N = 41 articles met the inclusion criteria and N = 16 articles failed to assess management of meningioma recurrence. Finally, N = 24 articles were included in our review. Results: The articles were distributed as follows: studies on chemotherapy (N = 14), radiotherapy, protontherapy, and stereotaxic radiosurgery (N = 6), boron-neutron capture therapy (N = 2) and surgery (N = 3). No study seems to provide serious alternatives to surgery in terms of progression-free and overall survival. Recurrence can occur long after the initial surgery and also affects WHO grade 1 meningiomas, even after initial gross total resection at first surgery, emphasizing the need for a long-term and comprehensive follow-up. Conclusions: Surgery still seems to be the state-of-the-art management when it comes to meningioma recurrence, since none of the non-surgical alternatives show promising results in terms of progression-free and overall survival.

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“…12 In general, higher WHO grading has been associated with the poor prognosis of meningiomas. 19 World while, WHO grade III meningiomas show extremely aggressive behavior and high rates of recurrence. 20 In our study, in accordance to the histological type, the microcystic meningiomas (WHO I) had a surveillance rate of 60 months (lowest) in contrast with transitional (WHO I) with 122 months (highest).…”

Section: Discussionmentioning

confidence: 99%

“…23 Tumor size, location, and bone in ltration were reported as prognostic factors although these factors were not associated with the poor prognosis of recurrent meningioma. 17,19…”

Section: Discussionmentioning

confidence: 99%

Progression Free -survival According to Simpson Grade Resection and Histological Types of Meningiomas in the Mexican Population Progression Free-survival of Meningiomas in the Mexican Population

Hernández¹,

Moreno²,

Domínguez³

et al. 2021

Preprint

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Introduction: Meningiomas are the most common primary central nervous system (CNS) tumors, with an incidence of 8.14 per 100,000 habitants. They represent 30% of all adult primary brain tumor diagnoses in the United States in contrast to Latin America with 50%. In Mexico, there are no epidemiological trends of meningiomas or other CNS tumors. Simpson resection grade and WHO grade are the prognostic factors with the greatest effect. In this paper, we describe the correlation between the survival free of disease and the gross total resection with its histological type according to Simpson’s grading scale. Materials and methods: A descriptive, analytical, retrospective, case-control study was conducted in two public third -level hospitals and three second- level hospitals in two cities of Mexico, (Mexico City and Guadalajara, Jalisco in a period of 10 years (2010-2020). An analysis of measures of central tendency was performed for age, sex, location, histological type, and postsurgical Simpson grade.Results: 26 patients of 179 had recurrence. Among the total recurrences, 15.4% were Simpson 1, 69.2%Simpson 2, and 15.4%Simpson 3. The survival for Simpson 1 was 142.0 months, Simpson 2 90.32 months, and Simpson 3 69.13 months. According to the histological type, the meningiomas with the lowest survival were the microcystic ones with 60 months, followed by the atypical ones with 90.4 months, and the psammomatous ones with 99.8 months. Conclusion: Surgical resection and the histological type are factors that affect progression free -survival. The Mexican population presents characteristics similar to those described in world literature.Importance of the study: This is the first study of its kind in the Mexican population and lays the foundations for future studies in the Latin American population.

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Long-Term Clinical Outcome of First Recurrence Skull Base Meningiomas

Cited by 5 publications

References 36 publications

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas

Management of Recurrent Meningiomas: State of the Art and Perspectives

Progression Free -survival According to Simpson Grade Resection and Histological Types of Meningiomas in the Mexican Population Progression Free-survival of Meningiomas in the Mexican Population

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