Long-term clinical efficacy in grass pollen–induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet

Mechanisms of allergen-specific immunotherapy

“…Although sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) are the two main routes of administration, SLIT seems to be the more safe and favorable route of both. Several large-scaled, randomized, double-blinded, placebo-controlled trials demonstrated the long lasting and diseasemodifying effects of SLIT [84][85][86][87][88]. Oral SIT possesses a high potential for the development of novel treatment modalities.…”

Specific immunotherapy in grass pollen allergy

“…Finally, the clinical data recently published with tablet SIT administered with a perennial protocol, demonstrated a long-term effect in the treated group compared with placebo group, one and two years after stopping SIT. 3,29 Asthma risk reduction in patients desensitized for allergic rhinitis. Few studies have explored this complex question.…”

Treating allergic rhinitis by sublingual immunotherapy: a review

“…The major advantage of AIT takes place when the treatment, usually after 3 years, is stopped, because the effectiveness of AIT persists over time [37]. Such persistence is related to the immunologic changes induced by AIT, especially regarding the T lymphocytes and their cytokine profile and the production of IgG blocking antibodies [38] and the consequent modification of the natural history of respiratory allergy [39]. Recent studies expanded the concept of economic advantage of AIT even before its termination.…”