Long-term clearance from small airways decreases with age

Svartengren, Magnus; Falk, Rolf; Philipson, Klas

doi:10.1183/09031936.05.00002105

Cited by 124 publications

(100 citation statements)

References 29 publications

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“…The positive rate of H. influenzae detection was higher among the older patients, probably reflecting impaired mucociliary clearance and underlying chronic respiratory illness among them (21,22). H. influenzae is commonly involved in acute exacerbation of chronic bronchitis and chronic obstructive pulmonary disease (23).…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Community-Acquired Pneumonia among Rapidly Aging Population in Japan: A Prospective Hospital-Based Surveillance

et al. 2014

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SUMMARY:The age-group-specific incidence and etiological patterns of community-acquired pneumonia (CAP) have not been fully established in Japan. A 2-year prospective surveillance was conducted in Kochi city, Western Japan. All CAP patients aged AE15 years who visited a community-based hospital were enrolled in the study. Clinical samples were examined by conventional bacterial culture and urinary antigen tests, and 6 bacterial pathogens and 16 respiratory viruses were identified from sputum samples by multiplex polymerase chain reaction assays. The age-group-specific incidence of CAP was estimated using a population-based data set of the total number of outpatients in the whole city.

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Section: Discussionmentioning

confidence: 99%

High Incidence of Community-Acquired Pneumonia among Rapidly Aging Population in Japan: A Prospective Hospital-Based Surveillance

et al. 2014

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“…However, there hypotheses for the cause of air trapping in lungs of elderly people. Progressive decline in respiratory and cardiac function causes alteration of alveolar dead space and shunts, possibly contributing to air trapping [4].…”

Section: Discussionmentioning

confidence: 99%

“…Air trapping is a term to describe retention of gas in all or part of a lung in the expiratory phase [4]. In one CT study, it was defined as an approximately 111.9 ± 46.3 (mean ± standard deviation) HU increase in mean lung attenuation in all three levels [5].…”

Section: Discussionmentioning

confidence: 99%

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CT features of normal lung change in asymptomatic elderly patients

Leelakanok

Piyavisetpat

2015

Asian Biomedicine

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Background: Not all morphological lung changes in the elderly contribute to respiratory disease and may be a consequence of normal aging. Objectives: To describe the changes in asymptomatic elderly patients compared with those in younger patients in a Thai population. Methods: The study cohort comprised 60 participants without respiratory symptoms in three groups of 20 by age: 20−40 years, 41−60 years, and >60 years. Participants were prospectively selected from patients referred for computed tomography (CT) of the abdomen, or head and neck, and underwent sequential CT during deep breathing at four lung levels. Two observers scored images by consensus. We compared groups using Pearson chi-square and Fisher exact tests, and used receiver operating characteristic curves to categorize bronchiectasis and bronchial wall thickening by age. Results: Air trapping was related to age (5/20 group 1, 7/20 group 2, and 18/20 group 3 (P <0.01)) and was most prevalent in lower lobes (78%, P < 0.01). Reticulation was found in only one middle aged patient (P = 0.36). Bronchiectasis was more common in patients <56 years (7/23) than <56 years (3/37), P = 0.035. Bronchial wall thickening (7/23 in patients >56 years and 2/37 in patients <56 years, P = 0.02) and extensive air trapping were related to age (0/6 group 1, 1/6 group 2, and 5/6 group 3, P = 0.02). Findings were independent of smoking history. Conclusions: Asymptomatic older patients had higher prevalence of bronchiectasis, bronchial wall thickening, and air trapping, independent of smoking history.

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“…It is reasonable to assume that this observed susceptibility is due to the effects of lung and cardiovascular diseases in older individuals. Svartengren et al (2005) reported that long-term small bronchial clearance of 6-μm diameter particles was negatively correlated to age in healthy subjects aged 19-81 years. Age is obviously a difficult parameter to incorporate in dosimetric calculations.…”

Section: Respiratory Tract Diseasementioning

confidence: 99%