Long-term Cholesterol-Lowering Effects of 4 Fat-Restricted Diets in Hypercholesterolemic and Combined Hyperlipidemic Men

Knopp, Robert H.

doi:10.1001/jama.1997.03550180059038

Cited by 129 publications

(15 citation statements)

References 38 publications

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“…36 We noted a trend for decreased diastolic blood pressure in women in this study with increasing isoflavone content of soy protein isolate. We have observed this effect previously in a study of postmenopausal women.…”

supporting

confidence: 50%

A Randomized Trial Comparing the Effect of Casein With That of Soy Protein Containing Varying Amounts of Isoflavones on Plasma Concentrations of Lipids and Lipoproteins

Crouse¹,

Morgan²,

Terry³

et al. 1999

Arch Intern Med

420

245

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Context: Isolated soy protein reduces plasma concentrations of total and low-density lipoprotein (LDL) cholesterol.Objective: To identify the agent(s) responsible for the cholesterol-lowering effect of soy in mildly hypercholesterolemic volunteers: isoflavones isolated together with soy protein or soy protein itself.Design: Double-blind randomized parallel trial.Setting: Single-center study.Participants: A total of 156 healthy men and women with LDL cholesterol levels between 3.62 mmol/L (140 mg/dL) and 5.17 mmol/L (200 mg/dL) after instruction in a National Cholesterol Education Program Step I diet and recruited by advertisement from the community.Intervention: One of 5 daily diets (25 g of casein [for isoflavone-free comparison] or 25 g of isolated soy protein containing 3, 27, 37, or 62 mg of isoflavones). Main Outcome Measures:Change and percent change from baseline in plasma concentrations of triglycerides and total, LDL, and high-density lipoprotein cholesterol after 9 weeks.Results: Compared with casein, isolated soy protein with 62 mg of isoflavones lowered total and LDL cholesterol levels by 4% (P = .04) and 6% (P = .01), respectively. In patients with LDL cholesterol levels in the top half of the population studied (Ͼ4.24 mmol/L [Ͼ164 mg/dL]), comparable reductions were 9% (PϽ.001) and 10% (P = 001), respectively; in this group, isolated soy protein with 37 mg of isoflavones reduced total (P = .007) and LDL (P = .02) cholesterol levels by 8%, and there was a dose-response effect of increasing amounts of isoflavones on total and LDL cholesterol levels. Plasma concentrations of triglycerides and high-density lipoprotein cholesterol were unaffected. Ethanol-extracted isolated soy protein containing 3 mg of isoflavones did not significantly reduce plasma concentrations of total or LDL cholesterol.Conclusions: Naturally occurring isoflavones isolated with soy protein reduce the plasma concentrations of total and LDL cholesterol without affecting concentrations of triglycerides or high-density lipoprotein cholesterol in mildly hypercholesterolemic volunteers consuming a National Cholesterol Education ProgramStep I diet. Ethanol-extracted isolated soy protein did not significantly reduce plasma concentrations of total or LDL cholesterol.

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supporting

confidence: 50%

A Randomized Trial Comparing the Effect of Casein With That of Soy Protein Containing Varying Amounts of Isoflavones on Plasma Concentrations of Lipids and Lipoproteins

Crouse¹,

Morgan²,

Terry³

et al. 1999

Arch Intern Med

420

245

View full text Add to dashboard Cite

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“…However, differences such as dietary pattern and the population studied limit further interpretation of these study findings. In an intervention study, HDL-C decreased by 3% in subjects consuming diets containing o25% of energy from fat (Po0.05) (Knoop et al, 1997). A recent crosssectional study (SHARE) which included Asians among other ethnic population (Europeans, South Asians in Canada and Chinese), did not show an inverse association between HDL-C concentration and glycemic load (Anwar et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults

et al. 2007

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Objective: To examine the relationship between dietary carbohydrates, glycemic load and high-density lipoprotein cholesterol (HDL-C) concentrations in Asian Indians, a high-risk group for diabetes and premature coronary artery disease. Subjects/methods: The study population comprised of 2043 individuals aged X20 years randomly selected from Chennai Urban Rural Epidemiological Study (CURES), an ongoing population-based study on a representative population of Chennai (formerly Madras) city in southern India. Participants with self-reported history of diabetes or heart disease or on drug therapy for dyslipidemia were excluded from the study. Dietary carbohydrates, glycemic index and glycemic load were assessed using a validated interviewer administered semiquantitative Food Frequency Questionnaire (FFQ). Results: Both dietary glycemic load (Po0.0001) and total dietary carbohydrate intake (Po0.001) were significantly associated with higher serum triglyceride levels and lower serum HDL-C levels. For the lowest to highest quintile of glycemic load, the multivariate-adjusted mean HDL-C values were 44.1 mg per 100 ml and 41.2 mg per 100 ml (6.6% difference, P for trendo0.001), while for total carbohydrate it was less (5% difference, P for trend ¼ 0.016). The pattern of decrease in HDL-C for the lowest to highest quintile of glycemic load was more pronounced among men (1st vs 5th quintile: adjusted HDL-C: 4.3 mg per 100 ml decrease (10.3%)) than women (1st vs 5th quintile: adjusted HDL-C: 3.2 mg per 100 ml decrease (6.9%)). Conclusion: Our findings indicate that both total carbohydrates and dietary glycemic load intake are inversely associated with plasma HDL-C concentrations among Asian Indians, with dietary glycemic load having a stronger association.

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“…Vergleichbare Be− schwerden traten auch in einer anderen Studie auf [34] und fan− den sich wiederholt in früheren Untersuchungen [26]. [37]. Eine eu− oder hypokalorische Ernährung mit einer mäßigen Fettreduktion auf etwa 30 % der Energie geht des− halb nicht mit einem atherogenen Lipoproteinprofil im Plasma einher, sondern auf lange Sicht mit einer Senkung des Körperge− wichts und mit daraus resultierenden günstigen Veränderungen der Plasmalipoproteine [9,38].…”

Section: Originalbeitrag 67unclassified

Fettarme oder fettreiche Ernährung? - der Königsweg liegt in der Mitte

Wolfram¹

2007

Akt Ernähr Med

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Long-term Cholesterol-Lowering Effects of 4 Fat-Restricted Diets in Hypercholesterolemic and Combined Hyperlipidemic Men

Cited by 129 publications

References 38 publications

A Randomized Trial Comparing the Effect of Casein With That of Soy Protein Containing Varying Amounts of Isoflavones on Plasma Concentrations of Lipids and Lipoproteins

A Randomized Trial Comparing the Effect of Casein With That of Soy Protein Containing Varying Amounts of Isoflavones on Plasma Concentrations of Lipids and Lipoproteins

Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults

Fettarme oder fettreiche Ernährung? - der Königsweg liegt in der Mitte

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