Long-term Change of Subfoveal Choroidal Thickness in Behçet’s Disease Patients with Posterior Uveitis

Park, Un Chul; Cho, In Hwan; Moon, Sang Woong; Yu, Hyeong Gon

doi:10.1080/09273948.2016.1268169

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…In this study, we demonstrated that consistently high or increasing serum CRP levels over a 7-year period was associated with thinner choroids, one of the most vascular tissues in the eye. This finding aligns with those of previous studies on individuals with systemic autoimmune diseases where longer duration of disease activity, and thus prolonged duration of elevated CRP levels, was linked to thinner subfoveal choroids 5,32 . Park et al 5 estimated that the subfoveal choroid is thinner by 0.44 μm for each additional month of inflammatory disease activity.…”

Section: Discussionsupporting

confidence: 92%

“…This finding aligns with those of previous studies on individuals with systemic autoimmune diseases where longer duration of disease activity, and thus prolonged duration of elevated CRP levels, was linked to thinner subfoveal choroids 5,32 . Park et al 5 estimated that the subfoveal choroid is thinner by 0.44 μm for each additional month of inflammatory disease activity. Our observation suggests that chronic inflammation, as measured using CRP levels, may be linked with thinner choroidal thicknesses since young adulthood, even if the inflammation is subclinical.…”

Section: Discussionsupporting

confidence: 92%

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Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

Lee

Beales

Chen

et al. 2021

Sci Rep

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Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18–22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of sample), increasing (11%), or consistently high (11%). 340 and 1035 participants were included in the choroidal and retinal thickness analyses, respectively. Compared to those in the “Low” trajectory group, participants in the “Increasing” and “High” groups had 14–21 μm thinner choroids at most macular regions. Every additional pack-year smoked was linked with a 0.06–0.10 μm thinner retina at the inner and outer macular rings, suggesting a dose-dependent relationship between smoking and thinner retinas. These associations may suggest that an increased risk of future visual impairment or eye disease associated with these risk factors may be present since young adulthood.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

Lee

Beales

Chen

et al. 2021

Sci Rep

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“…Yesilirmak et al [12] found that choroidal thickness was significantly thinner in patients with Behcet's disease-associated uveitis in end-stage phase compared with that in normal subjects. Park et al [13] also discovered that choroidal thickness decreased over time in patients with Behcet's disease-associated uveitis and the mean change rate was greater than that in controls (-7.2 versus -2.0 μm/year; P < 0:001). These may help explain the negative correlation between RF and choroidal thickness in our study.…”

Section: Journal Of Immunology Researchmentioning

confidence: 95%

“…Fang et al [27] demonstrated that C-reactive protein was significantly negatively related to choroidal thickness before the emergence of ocular symptoms. In patients with uveitis, the choroidal thickness displayed significant changes on OCT [12,13]. Yesilirmak et al [12] found that choroidal thickness was significantly thinner in patients with Behcet's disease-associated uveitis in end-stage phase compared with that in normal subjects.…”

Section: Journal Of Immunology Researchmentioning

confidence: 99%

“…The thickness of the retina and choroid can be affected by both systemic diseases and physiological conditions [7,8]. Several studies have pointed out that the thickness of the retina and choroid in patients with autoimmune disease-associated uveitis displays significant changes on OCT [9][10][11][12][13][14]. However, no research has evaluated the associations between serum RF and thickness of the retina and choroid before the emergence of ocular symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography

Qian

et al. 2021

Journal of Immunology Research

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Purpose. Researches have confirmed that the retinal and choroidal thickness in patients with autoimmune disease-associated uveitis displays significant changes. However, the relationships between rheumatoid factor (RF) and thickness of the retina and choroid in individuals without ocular manifestations remain unclear. The aim of this study is to assess the associations of RF with retinal and choroidal thickness. Methods. The individuals enrolled in the cross-sectional research received full ocular examinations. The participants were classified as the RF (+) group ( RF ≥ 15.0 IU/ml) and the RF (−) group ( RF < 15.0 IU/ml) according to the serum RF titers. The thickness of the retina and choroid was measured by swept-source optical coherence tomography (SS-OCT). Results. The study covered 65 right eyes of 65 individuals that are RF-positive and 130 right eyes of 130 age- and sex-matched individuals that are RF-negative. The RF (+) group showed decreased choroidal thickness that achieved statistical significance only in the outer inferior and outer temporal sectors, as compared to the RF (−) group. There was no statistically significant difference regarding the retinal thickness between the two groups. Pearson’s correlation analysis revealed that the RF was significantly negatively related to the choroidal thickness in all areas. However, there was no significant correlation between the RF and the retinal thickness. Conclusions. Serum RF titers are closely linked with choroidal thickness before the emergence of ocular symptoms. Research into the relationships may improve our understanding of the role of serum RF in the pathogenesis of uveitis.

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Retinal Manifestations of the Rheumatic Diseases

Smith

Rihani

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Long-term Change of Subfoveal Choroidal Thickness in Behçet’s Disease Patients with Posterior Uveitis

Abstract: In BD patients, choroidal thickness decreased over time, which was associated with length of active inflammation. It suggests intraocular inflammation in BD affects the choroid as well as the retina.

Cited by 17 publications

References 25 publications

Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography

Retinal Manifestations of the Rheumatic Diseases

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