Long-term central nervous system (CNS) consequences of COVID-19 in children

Howe de la Torre, Saskia; Parlatini, Valeria; Cortese, Samuele

doi:10.1080/14737175.2023.2239500

Cited by 7 publications

(6 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The correlation between TLR4 dimerization and activation with pathogenicity of the SARS-CoV-2 variants indicate TLR4 as a potential therapeutic target for treatment of COVID-19. While so far there are no FDA approved TLR4 antagonists available, intensive research [106] on TLR4 as a therapeutic target is ongoing, with emphasis on respiratory and neurological complications of SARS-CoV-2 [107], also with respect to accumulating data for long-term nervous system consequences after COVID-19 [108,109]. Beside various TLR4 antagonists which inhibit binding to or dimerization of TLR4, also inhibitors of the downstream signaling pathways, including inhibitors of the NF-κB pathway, are promising targets for therapeutic intervention [50,51].…”

Section: Discussionmentioning

confidence: 99%

In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

Kircheis

2024

IJMS

View full text Add to dashboard Cite

The SARS-CoV-2 Omicron variants have replaced all earlier variants, due to increased infectivity and effective evasion from infection- and vaccination-induced neutralizing antibodies. Compared to earlier variants of concern (VoCs), the Omicron variants show high TMPRSS2-independent replication in the upper airway organs, but lower replication in the lungs and lower mortality rates. The shift in cellular tropism and towards lower pathogenicity of Omicron was hypothesized to correlate with a lower toll-like receptor (TLR) activation, although the underlying molecular mechanisms remained undefined. In silico analyses presented here indicate that the Omicron spike protein has a lower potency to induce dimerization of TLR4/MD-2 compared to wild type virus despite a comparable binding activity to TLR4. A model illustrating the molecular consequences of the different potencies of the Omicron spike protein vs. wild-type spike protein for TLR4 activation is presented. Further analyses indicate a clear tendency for decreasing TLR4 dimerization potential during SARS-CoV-2 evolution via Alpha to Gamma to Delta to Omicron variants.

show abstract

Section: Discussionmentioning

confidence: 99%

In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

Kircheis

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…As for adults, CNS dysfunction seems to persist for a long time in a significant portion of infected pediatric patients, resulting in so-called Long COVID-19 [1,5,6,38,39]. Headache, fatigue, 'brain fog' and memory impairment, anosmia or ageusia, and dizziness are the most frequent symptoms associated with Long COVID-19, with a highly variable prevalence among the studies [1,5,6,40].…”

Section: Discussionmentioning

confidence: 99%

“…Neuropsychiatric symptoms are also described in patients with Long COVID-19, especially mood symptoms and anxiety, affecting their daily functioning and well-being [6,8,41]. The direct effects of the virus are not the sole contributors, as pandemic-related psychosocial factors have also influenced this group of patients in an unclear manner.…”

Section: Discussionmentioning

confidence: 99%

“…However, despite the low risk of severe acute COVID-19 in the pediatric population, it has been widely demonstrated that SARS-CoV-2 infection can lead to the onset of long-term multisystem sequelae, currently referred to as Long COVID-19 [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies suggest that neurological and neuropsychiatric symptoms may differ in the underlying pathophysiology. SARS-CoV-2 infection seems to have a key role in the development of neurological symptoms, while social isolation and pandemic-related restrictions seem to play a relevant role in neuropsychiatric manifestations, such as mood problems [6,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuropsychological Symptoms and Quality of Life during the COVID-19 Pandemic in Children: A Survey in a Pediatric Population in the Abruzzo Region, Italy

Marcotullio,

Attanasi,

Porreca

et al. 2024

Children

View full text Add to dashboard Cite

Background: The SARS-CoV-2 pandemic has significantly affected the pediatric population. Long-term sequelae (Long COVID-19) may particularly involve the central nervous system, with possible effects on psychological well-being and quality of life (QoL), aspects that were already influenced by the restrictive measures and general social impact of the pandemic. Methods: We conducted a cross-sectional survey that aims at investigating the neuropsychological effects and the QoL impairment of SARS-CoV-2 on a cohort of children and adolescents in the Abruzzo region (Italy). A questionnaire was submitted to caregivers with the help of the PEDIATOTEM platform. A control group of healthy subjects was also included to distinguish between the effects of infection from the general influence of the pandemic. Results: A total of 569 subjects responded: 396 COVID-19 patients (99 of whom had Long COVID-19) and 111 controls. After the pandemic, when compared with the COVID-19 group, the controls reported significantly increased appetite, sleeping habits, and time spent remotely with friends and a reduction in physical activity and time spent in person with friends. A significant higher rate of controls asked for psychological/medical support for emotional problems. On the other hand, the Long COVID-19 group showed more fatigue and emotional instability with respect to non-Long-COVID-19 subjects. No differences in QoL results (EuroQOL) were found between the COVID-19 patients and controls, while the Long-COVID-19 subgroup showed significantly higher rates of pain/discomfort and mood instability, as confirmed by the analysis of variation of responses from the pre-COVID-19 to the post-COVID-19 period. Conclusions: Among COVID-19 patients, neuropsychological and QoL impairment was more evident in the Long COVID-19 subgroup, although emotional and relational issues were also reported by uninfected patients, with a growing request for specialist support as a possible consequence of social restriction.

show abstract

Problems in the Diagnosis of Dysfunctions of the Olfactory Analyzer in Laboratory Animals Based on Behavioral and Electrophysiological Study Methods

Gorskaya,

Vasilev

2024

Neurosci Behav Physi

View full text Add to dashboard Cite

Long-term central nervous system (CNS) consequences of COVID-19 in children

Cited by 7 publications

References 147 publications

In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

Neuropsychological Symptoms and Quality of Life during the COVID-19 Pandemic in Children: A Survey in a Pediatric Population in the Abruzzo Region, Italy

Problems in the Diagnosis of Dysfunctions of the Olfactory Analyzer in Laboratory Animals Based on Behavioral and Electrophysiological Study Methods

Contact Info

Product

Resources

About