Long-term Cardiovascular Outcomes Among Endometrial Cancer Survivors in a Large, Population-Based Cohort Study

Abstract

Endometrial cancer survivors are at higher risk for various adverse long-term cardiovascular outcomes compared with women from the general population. This study suggests that increased monitoring for cardiovascular diseases may be necessary for endometrial cancer patients for 10 years after cancer diagnosis.

Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study

“…This study had several limitations such as possible errors in ICD coding and missing less severe cases of diabetes. The sensitivity (88.6%) and specificity (90.9%) using EMR and statewide healthcare databases to identify diabetes diagnoses among endometrial cancer patients in the study was fairly high [4]. Because we used ICD-9 codes and medical records as the source for diabetes diagnosis, we cannot eliminate the possibility of coding errors, although we would not expect such errors to be differential in cancer patients and the general population.…”

“…Additionally, the women in the study may have been diagnosed with diabetes in hospitals not covered by our data sources. However, approximately 99.6% of the endometrial cancer patients and 98.5% of the general population cohort did have records in these data sources, particularly since we have statewide coverage for inpatient stays and ambulatory surgery [4]. Another limitation was the missing baseline BMI for some of our study subjects.…”

“…We previously compared self-reported diabetes from a subset of the endometrial cancer patients (n ¼ 221) and EMR/statewide data that was used in this study to investigate concordance for various diseases including diabetes. Patients' self-report was considered as the gold standard and the sensitivity and specificity for diabetes were 88.6% and 90.9%, respectively [4].…”

“…As of 2017, an estimated 757,190 endometrial cancer survivors live in the United States [3]. Long-term chronic disease risks are of concern among endometrial cancer patients, since the majority are obese at diagnosis [4,5]. We previously reported on increased risks of cardiovascular disease and genitourinary outcomes among endometrial cancer survivors [4,5].…”

Survivors of endometrial cancer are more likely to experience cardiovascular problems

“…The research, published in the Journal of the National Cancer Institute , also demonstrated that survivors of endometrial cancer were 47% more likely to be diagnosed with heart disease between 1 to 5 years after diagnosis and 33% more likely to be diagnosed with heart disease between 5 to 10 years after diagnosis . The investigators identified the survivors through the Utah Population Database, which included diagnosis data for women aged 18 years and older residing in Utah who were diagnosed with endometrial cancer between 1997 and 2012.…”