Long-term cardiorespiratory outcomes in Congenital Diaphragmatic Hernia

Lewis, L; Sinha, I; Kang, S; Lim, J; Losty, P

doi:10.1183/13993003.congress-2022.3277

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This crucial period acts as a protective shield, molding the resilience of individuals against respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD, a progressive lung disease characterized by airflow limitation that is not fully reversible), and interstitial lung diseases. Evidence from various studies suggests that disruptions in fetal lung development can elevate the risk of developing these respiratory conditions and systemic health problems in adulthood [24,25,[85][86][87]. Therefore, the proper orchestration of lung development pathways plays a pivotal role in preventing or establishing resilience against such diseases [83].…”

Section: Importance Of Proper Fetal Lung Development For Postnatal He...mentioning

confidence: 99%

“…Each stage is characterized by a unique sequence of morphological transformations, progressively sculpting a fully functional respiratory organ [2,19,20]. Disruptions at any stage can lead to conditions like con-genital diaphragmatic hernia or pulmonary hypoplasia, which, while immediately impactful on neonatal health, may also have long-term effects and predispose individuals to chronic respiratory ailments extending into adulthood [21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review

Yaremenko,

Pechnikova,

Porpodis

et al. 2024

JPM

View full text Add to dashboard Cite

Fetal lung development is a crucial and complex process that lays the groundwork for postnatal respiratory health. However, disruptions in this delicate developmental journey can lead to fetal lung development disorders, impacting neonatal outcomes and potentially influencing health outcomes well into adulthood. Recent research has shed light on the intriguing association between fetal lung development disorders and the development of adult diseases. Understanding these links can provide valuable insights into the developmental origins of health and disease, paving the way for targeted preventive measures and clinical interventions. This review article aims to comprehensively explore the association of fetal lung development disorders with adult diseases. We delve into the stages of fetal lung development, examining key factors influencing fetal lung maturation. Subsequently, we investigate specific fetal lung development disorders, such as respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and other abnormalities. Furthermore, we explore the potential mechanisms underlying these associations, considering the role of epigenetic modifications, transgenerational effects, and intrauterine environmental factors. Additionally, we examine the epidemiological evidence and clinical findings linking fetal lung development disorders to adult respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and other respiratory ailments. This review provides valuable insights for healthcare professionals and researchers, guiding future investigations and shaping strategies for preventive interventions and long-term care.

show abstract