Long-term cardiac allograft survival in mice treated with malononitrilamide 715

Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs

“…Cryopreserved allogeneic heart valves have been widely used to reconstruct the left ventricular outflow tract in the repair of diverse congenital cardiac anomalies (1)(2)(3)(4). However, these tissues often fail in young patients (5), especially infants (6,7).…”

An Evaluation of Combined Immunosuppression with MNA 715 and Microemulsified Cyclosporine on Renal Allograft Rejection in Mismatched Mongrel Dogs

“…The efficacy of leflunomide and the MNA analogue, MNA 715 (FK778), for the prevention and treatment of rejection has been demonstrated in a number of models of allograft and xenograft rejection. MNA 715 dose‐dependently inhibits cardiac allograft rejection in mice 22 and rats, 23 prevents accelerated rejection of secondary rat cardiac allografts, 24 prevents and treats skin allograft rejection in rats, 25 and inhibits the development of graft‐versus‐host disease in mice 26 . MNA 715 also inhibits rejection in the mouse‐to‐rat skin 27 and hamster‐to‐rat cardiac xenograft models 28 .…”