Long-term callosal lesions and learning of a black-white discrimination by one-eyed rats

Ikeda, Yukinobu; Sakai, Makoto; Yagi, Fumio

doi:10.1016/0031-9384(92)90361-5

Cited by 6 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This genetic defect has been described only in humans and mice, permitting the potential comparison of behavioural consequences of congenital CC defects with those of CC transsection only in these: two species. To date, however, surgical techniques for CC transsection have been developed for humans (2,17), monkeys (6), cats (15), rabbits (18), and, with varied success, for rats (4,8,9,16), but never for mice. The technical difficulties inherent in transsecting this relatively small structure in the mouse have thus far prevented attempts at developing a surgical technique for callosotomy in the mouse.…”

Section: Articlementioning

confidence: 99%

A precision surgical approach for complete or partial callosotomy in the mouse

Schalomon

Wahłsten

1995

Physiology & Behavior

View full text Add to dashboard Cite

The corpus callosum (CC) of mice was completely transsected with a thin tungsten knife using a three-cut approach through the dorsal cerebrum just lateral to midline. This method results in almost total transsection of the CC throughout its entire rostrocaudal extent. Advantages of this approach include minimal bleeding and extracallosal damage as well as the possibility of selective transsection of only anterior, middle, or posterior parts of the CC. The technique can be readily adapted to any other rodent species.

show abstract

Section: Articlementioning

confidence: 99%

A precision surgical approach for complete or partial callosotomy in the mouse

Schalomon

Wahłsten

1995

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…A number of investigations have suggested that terminal proliferation or reactive synaptogenesis is trig- (Ikeda et al, 1992) gered and facilitated by neurotrophic factors, released either by glial cells or neurons in the course of terminal degeneration (e.g., Cotman & Nadler, 1978;Manthorpe, Nieto-Sampedro, Skaper, Lewis, Barbin, Longo, Cotman, & Varon, 1983). The degree of reactive synaptogenesis is influenced by many factors, such as the amount of released neurotrophic factors, age, the primed state of terminals to sprout, etc.…”

Section: Shrinkage Of the Ipsilateralmentioning

confidence: 99%

“…This "faster" relearning phenomenon of OEBs is considered to be a behavioral expression of the above mentioned reorganization in the visual system. However, our previous studies (Ikeda et al, 1988;Ikeda et al, 1992;Ikeda et al, 1983;Sakai et al, 1991;Sakai et al, 1996;Yagi & Sakai, 1979;Yagi et al, 1989) have also demonstrated that neither OEBs nor OETs are able to master BW discrimination when the discrimination training is given at 3 months of age and made 10 days after damage of the CT visual cortex. We interpret the reason for the inability to discriminate as follows: In postoperative original learning, rats have to learn to extract the experimenter's defined relevant cues for discrimination from various kinds of potential stimuli, and this might still be difficult, even for OEBs that possess expanded uncrossed visual pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Behaviorally, 3-month-old rats with one eye removed at birth (OEBs) can relearn a black-white (BW) discrimination faster than those rats with one eye removed at 13 weeks of age (OETs), when relearning is initiated 10 days after lesions of the visual cortex contralateral to the remaining eye (CT visual cortex). In this case the CT visual cortex lesions are made the day following the completion of original learning (Ikeda, Sakai, & Yagi,1988;Ikeda, Sakai, & Yagi, 1992;Ikeda, Yagi, & Sakai, 1983;Sakai, Ikeda, & Yagi, 1991;Sakai, Ikeda, & Yagi, 1996;Yagi & Sakai, 1979;Yagi, Sakai, & Ikeda, 1989). This "faster" relearning phenomenon of OEBs is considered to be a behavioral expression of the above mentioned reorganization in the visual system.…”

Section: Introductionmentioning

confidence: 99%

“…During an investigation of the behavioral functions of the expanded uncrossed visual pathways in OEBs, we studied the possibility of neural reorganization in the IP visual cortex, which would be brought out by long-term callosal deafferentation. Specifically, we (Ikeda et al, 1992) examined the effects of callosal transections made at 3 weeks of age and at 13 weeks of age upon the acquisition of BW discrimination using OEBs and OETs. Ten weeks following the callosal transections, rats received the CT visual cortex lesions, and after a recovery period of 10 days, the discrimination training was started.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-term unilateral visual cortical lesions and learning of a black-white discrimination by one-eyed rats

Ikeda

Sakai

Yagi

2000

Jpn. J. Physiol. Psychol. Psychophysiol.

Self Cite

View full text Add to dashboard Cite

In a previous study we investigated the effects of callosal transected lesions made 10 weeks earlier (the 10-week-old callosal transected lesions), either at 3 weeks of age or at 13 weeks of age, upon the acquisition of a black-white (BW) discrimination in rats either with one eye removed at birth (OEB) or at 13 weeks of age (OET) following lesions of the contralateral (CT) visual cortex to the remaining eye. The CT visual cortex lesions were performed right before the training of BW discrimination. We found that the 10-week-old callosal transected lesions facilitated the acquisition in OEBs when the callosal lesions were given at 3 weeks of age, and to a lesser extent at 13 weeks of age. We also found that the same type of callosal transected lesions did not do so in OETs, regardless of the age when the callosal lesions were made.Since the CT visual cortex lesions inevitably result in damage of the callosal neurons, and lead to degeneration of the callosal afferents in the ipsilateral (IP) visual cortex, the present study was undertaken to investigate if the CT visual cortex lesions made 10 weeks earlier (the 10-week-old CT visual cortex lesions), made either at 3 weeks of age or 13 weeks of age, would affect the acquisition of BW discrimination in OEBs and OETs, like the 10-week-old callosal transected lesions employed in the previous study mentioned above.We found that in both OEBs and OETs the overall pattern of the facilitation effects of the 10-week-old CT visual cortex lesions on the acquisition of BW discrimination is, in general, the same as that observed in the 10-week-old callosal transected lesions, but the facilitative effect of the 10-week-old CT visual cortex lesions is more prevailing and pronounced. The findings are discussed in relation to the possible involvement of neurotrophic factors, released when the CT visual cortex lesions were made, in synaptic reorganization, and also in relation to the possibility of the increased use of the uncrossed visual pathways.

show abstract