Long-term BTX-A effects on bi-articular muscle: Higher passive force, limited length range of active force production and unchanged intermuscular interactions

Yılmaz, Evrim O.; Kaya, Cemre S.; Akdeniz-Doğan, Zeynep D.; Yücesoy, Can A.

doi:10.1016/j.jbiomech.2021.110627

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…One key biomechanical finding of animal studies noteworthy of clinical testing is that the BTX group also showed elevated muscle passive forces (e.g., Kaya et al). Another potentially functionally important biomechanical finding shown in animal studies was a decrease in length range of force production reported for muscles exposed to BTX Yilmaz et al, 2021). Therefore, studies on what happens before and after botulinum toxin injections in the muscle in children with CP is highly warranted.…”

Section: Clinical Implications: Mechanisms Of Pathological Conditions and Treatment Techniques With A Special Emphasis On Spastic Cerebramentioning

confidence: 99%

Editorial: Muscle Mechanics, Extracellular Matrix, Afferentation, Structural, and Neurological Coupling and Coordination in Health and Disease

et al. 2021

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Section: Clinical Implications: Mechanisms Of Pathological Conditions and Treatment Techniques With A Special Emphasis On Spastic Cerebramentioning

confidence: 99%

Editorial: Muscle Mechanics, Extracellular Matrix, Afferentation, Structural, and Neurological Coupling and Coordination in Health and Disease

et al. 2021

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Effects of elastic therapeutic taping on along-muscle fascicle local length changes: Magnetic resonance and diffusion tensor imaging based assessment

Yildiz,

Arpak,

Yucesoy

2023

Journal of Biomechanics

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Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles

Keles¹,

Ateş²

2022

Toxins

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Spasticity, following the neurological disorder of cerebral palsy (CP), describes a pathological condition, the central feature of which is involuntary and prolonged muscle contraction. The persistent resistance of spastic muscles to stretching is often followed by structural and mechanical changes in musculature. This leads to functional limitations at the respective joint. Focal injection of botulinum toxin type-A (BTX-A) is effectively used to manage spasticity and improve the quality of life of the patients. By blocking acetylcholine release at the neuromuscular junction and causing temporary muscle paralysis, BTX-A aims to reduce spasticity and hereby improve joint function. However, recent studies have indicated some contradictory effects such as increased muscle stiffness or a narrower range of active force production. The potential of these toxin- and atrophy-related alterations in worsening the condition of spastic muscles that are already subjected to changes should be further investigated and quantified. By focusing on the effects of BTX-A on muscle biomechanics and overall function in children with CP, this review deals with which of these goals have been achieved and to what extent, and what can await us in the future.

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Long-term BTX-A effects on bi-articular muscle: Higher passive force, limited length range of active force production and unchanged intermuscular interactions

Cited by 3 publications

References 56 publications

Editorial: Muscle Mechanics, Extracellular Matrix, Afferentation, Structural, and Neurological Coupling and Coordination in Health and Disease

Editorial: Muscle Mechanics, Extracellular Matrix, Afferentation, Structural, and Neurological Coupling and Coordination in Health and Disease

Effects of elastic therapeutic taping on along-muscle fascicle local length changes: Magnetic resonance and diffusion tensor imaging based assessment

Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles

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