Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study)

Han, Doo Hee; Shin, Jae Min; An, Seokyung; Kim, Jong Seung; Kim, Dong Young; Moon, Sungji; Kim, Jung Soo; Cho, Joong Saeng; Kim, Si Whan; Kim, Young Hyo; Roh, Hwan Jung; Shim, Woo Sub; Rha, Ki-Sang; Kim, Sang Wook; Lee, Seung Sin; Kim, Dae Woo; Cho, Kyu‐Sup; Yim, Hyo Jin; Park, Sung Sup; Rhee, Chae Seo

doi:10.21053/ceo.2018.01781

Cited by 27 publications

(33 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our ndings are consistent with most previous studies in which CS delivery, only one child in the household and formula feeding were associated with an increased risk of allergic diseases among children [6][7][8][12][13][14][15][16][17][18]. Recently, a systematic review and meta-analysis reported that male sex, short duration of breastfeeding and having siblings were risk factors of early transient wheezing among children aged 3-18 years) [19].…”

Section: Discussionsupporting

confidence: 92%

“…Another study in Shanghai found that CS without medical indication was associated with increased risks of both childhood asthma and AR, and breastfeeding in early infancy attenuated these risks [6]. The Allergic Rhinitis Cohort Study for kids conducted in South Korea found that long-term breastfeeding (≥ 12 months) and a vaginal delivery were associated with a lower risk of developing childhood AR [7]. However, in two unselected populations using harmonised protocols in Australia, the association of CS with developing childhood allergy was weak, and no modi cation effects by breastfeeding duration were found [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exclusive Breastfeeding Duration Modified the Effects of Neonatal and Familiar Risk Factors on Childhood Asthma and Allergy: A Population-Based Study

Chen

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Childhood asthma and allergic diseases are a significant global problem. There are inconsistent findings on the associations of delivery mode, the number of children in the household and breastfeeding with childhood asthma and allergic diseases. We assessed these associations and examined whether breastfeeding modified the effects of neonatal and familiar risk factors on childhood asthma and allergic diseases.Methods: A population-based cross-sectional study was conducted in Shanghai, China. A total of 17 primary schools were randomly selected from 13 districts of Shanghai in this study. The International Study of Asthma and Allergies in Childhood questionnaire was adopted to assess the childhood asthma and allergic diseases. Multivariable logistic regression models were used to evaluate the associations between neonatal and familiar factors and childhood asthma and allergic diseases, and to examine the modification effects of breastfeeding on the associations assessed.Results: Of 10,464 primary school children aged 6-11 years, the overall prevalence of childhood asthma, allergic rhinitis, urticarial, food allergy and drug allergy was 13.9%, 22.7%, 15.3%, 8.1% and 4.6%, respectively. Male sex, high socioeconomic status, cesarean section delivery, only one child in the household and having family history of allergy were among the major risk factors for childhood asthma and allergic diseases while longer exclusive breastfeeding duration (＞6 months) was a protective factor. Longer exclusive breastfeeding duration also attenuated the effects of neonatal and familiar risk factors on childhood asthma and allergic diseases. Conclusions: Longer exclusive breastfeeding duration was a protective factor against childhood asthma and allergic diseases, and also reduced the adverse effects of neonatal and familiar risk factors on these diseases. Giving the prevalence of childhood asthma and allergic diseases is rapidly rising across the globe, these findings may have important clinical and public health implications.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Exclusive Breastfeeding Duration Modified the Effects of Neonatal and Familiar Risk Factors on Childhood Asthma and Allergy: A Population-Based Study

Chen

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies have confirmed that Cesarean births correlate with an increased incidence of FA and asthma [5,6,[22][23][24]. The latest American cohort study in children born in the state of New York (n = 1356) in the years 2008-2010 showed that emergency C-section delivery was associated with a higher relative risk (RR) of wheezing (RR = 2.47, 95% CI 1.31-4.66) and FA (RR = 3.02, 95% CI 1.26-7.25) [22].…”

Section: Cesarean Sections the Microbiota And Allergy Developmentmentioning

confidence: 95%

The Relationship between the Infant Gut Microbiota and Allergy. The Role of Bifidobacterium breve and Prebiotic Oligosaccharides in the Activation of Anti-Allergic Mechanisms in Early Life

et al. 2020

View full text Add to dashboard Cite

The increase in allergy prevalence observed in recent decades may be a consequence of early intestinal dysbiosis. The intestinal microbiota is formed in the first 1000 days of life, when it is particularly sensitive to various factors, such as the composition of the mother’s microbiota, type of delivery, infant’s diet, number of siblings, contact with animals, and antibiotic therapy. Breastfeeding and vaginal birth favorably affect the formation of an infant’s intestinal microbiota and protect against allergy development. The intestinal microbiota of these infants is characterized by an early dominance of Bifidobacterium, which may have a significant impact on the development of immune tolerance. Bifidobacterium breve is a species commonly isolated from the intestines of healthy breastfed infants and from human milk. This review outlines the most important environmental factors affecting microbiota formation and the importance of Bifidobacterium species (with a particular emphasis on Bifidobacterium breve) in microbiota modulation towards anti-allergic processes. In addition, we present the concept, which assumes that infant formulas containing specific probiotic Bifidobacterium breve strains and prebiotic oligosaccharides may be useful in allergy management in non-breastfed infants.

show abstract

“…Allergic rhinitis markedly affects patients' quality of life, and it is a major reason for outpatient visits to otolaryngology clinics [1][2][3][4][5]. Allergic rhinitis is generally thought to be mediated by Th2, with interleukin (IL)-4, IL-5, and IL-13 also contributing to its pathogenesis [6].…”

Section: Introductionmentioning

confidence: 99%

Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Lee

Bae

Kim

et al. 2020

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

Objectives. Limited information is available regarding strain-related differences in mouse models of allergic rhinitis induced by Dermatophagoides farinae (Der f1). In this study, we compared differences between two mouse strains and determined the optimal dose of Der f1 for allergic rhinitis mouse models.Methods. Forty-eight mice were assigned to the following six groups (n=8 per group): group A (control, BALB/c), group B (Der f1-sensitized BALB/c, 25 µg), group C (Der f1-sensitized BALB/c, 100 µg), group D (control, C57BL/6), group E (Der f1-sensitized C57BL/6, 25 µg), and group F (Der f1-sensitized C57BL/6, 100 µg). Allergic inflammation was induced with Der f1 and alum sensitization, followed by an intranasal challenge with Der f1. Rubbing and sneezing scores, eosinophil and neutrophil infiltration, and immunoglobulin, cytokine, and chemokine levels in the nasal mucosa and from splenocyte cultures were assessed.Results. Rubbing and sneezing scores were higher in groups B, C, E, and F than in groups A and D, with a similar pattern in both strains (i.e., group B vs. E and group C vs. F). Serum immunoglobulin levels were significantly elevated compared to the control in groups B and C, but not in groups E and F. Eosinophil and neutrophil infiltration increased (all P<0.05) after the Der f1 challenge (groups B, C, E, and F) compared to the control (groups A and D) in both the BALB/c and C57BL/6 strains, without any significant difference between the two strains (group A vs. D, group B vs. E, and group C vs. F) (P>0.05). BALB/c mice (group B) showed a greater elevation of splenic interleukin (IL)-4 (P<0.01), IL-5 (P<0.01), and IL-6 levels (P<0.05) and nasal IL-4 mRNA levels (P<0.001) than the C57BL/6 mice (group E). Interestingly, mice treated with 100 µg Der f1 showed a weaker allergic response than those treated with 25 µg.Conclusion. We found 25 µg to be a more appropriate dose for Der f1 sensitization. BALB/c mice are more biased toward a Th2 response and are a more suitable model for allergic rhinitis than C57BL/6 mice. This study provides information on the appropriate choice of a mouse model for allergic rhinitis.

show abstract

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study)

Cited by 27 publications

References 36 publications

Exclusive Breastfeeding Duration Modified the Effects of Neonatal and Familiar Risk Factors on Childhood Asthma and Allergy: A Population-Based Study

Exclusive Breastfeeding Duration Modified the Effects of Neonatal and Familiar Risk Factors on Childhood Asthma and Allergy: A Population-Based Study

The Relationship between the Infant Gut Microbiota and Allergy. The Role of Bifidobacterium breve and Prebiotic Oligosaccharides in the Activation of Anti-Allergic Mechanisms in Early Life

Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Contact Info

Product

Resources

About