Long-term bone mineral density changes and fractures in lung transplant recipients with cystic fibrosis

Durette, Gabrielle; Jomphe, Valérie; Bureau, Nathalie J.; Poirier, Charles; Ferraro, Pasquale; Lands, Larry C.; Mailhot, Geneviève

doi:10.1016/j.jcf.2020.09.012

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…However, the correction of vitamin D did not improve abnormalities in calcium, bone turnover markers [ 51 ], and bone mineral density [ 52 ]. Moreover, cystic fibrosis patients that underwenta lung transplant remained at risk of skeletal fragility [ 53 ], perhaps due to prolonged treatment with oral corticosteroids in the post-transplantation period.…”

Section: Cystic Fibrosis-related Bone Diseasementioning

confidence: 99%

Cystic Fibrosis Bone Disease: The Interplay between CFTR Dysfunction and Chronic Inflammation

et al. 2023

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Cystic fibrosis is a monogenic disease with a multisystemic phenotype, ranging from predisposition to chronic lung infection and inflammation to reduced bone mass. The exact mechanisms unbalancing the maintenance of an optimal bone mass in cystic fibrosis patients remain unknown. Multiple factors may contribute to severe bone mass reduction that, in turn, have devastating consequences in the patients’ quality of life and longevity. Here, we will review the existing evidence linking the CFTR dysfunction and cell-intrinsic bone defects. Additionally, we will also address how the proinflammatory environment due to CFTR dysfunction in immune cells and chronic infection impairs the maintenance of an adequate bone mass in CF patients.

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Section: Cystic Fibrosis-related Bone Diseasementioning

confidence: 99%

Cystic Fibrosis Bone Disease: The Interplay between CFTR Dysfunction and Chronic Inflammation

et al. 2023

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“…Organ transplantation and CF related diabetes are independent risk factors for lower GI malignancy, suggesting that earlier screening may be beneficial in this population [50] . Furthermore, cardiovascular complications, obstructive sleep apnea, osteopenia and skeletal fragility are all emerging problems [51] , [52] , [53] , [54] , [55] . Addressing mental health issues and promoting emotional wellness warrant ongoing attention, particularly as those with depression are at increased risk of death [56] , [57] , [58] , [59] , [60] , [61] .…”

Section: Extrapulmonary Complicationsmentioning

confidence: 99%