Long-term Blood Pressure Variability and Cerebrovascular Changes on CT in a Community-based Elderly Population.

Tsukishima, Eri; Saito, Hiroya; Shido, Koichi; Kobashi, Gén; Ying-Yan, Gong; Kishi, Reiko; Niino, Minehisa; Kondo, Kiyotaro; Sugimura, Iwao

doi:10.2188/jea.11.190

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…These studies mostly used the SD CV as the BPV indicator but did not consider the potential confounding effect of the mean value of BP [31][32][33][34] . It is difficult to determine whether BPV has an independent risk effect on cSVD besides the absolute BP level.…”

Section: Discussionmentioning

confidence: 99%

Higher long-term visit-to-visit blood pressure variability is associated with severe cerebral small vessel disease in the general population

Zhao,

Ying,

et al. 2024

Preprint

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BackgroundLong-term blood pressure (BP) variability is related to several diseases, but its impact on cerebral small vessel disease (cSVD) is uncertain. The study explored the relationship between BP variability, total cSVD burden, and its typical features.MethodThe study involved 1284 participants from the Kailuan cohort. From 2006 to 2022, systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) variability were calculated as low, middle, or high. Magnetic resonance imaging was used to identify white matter hyperintensities (WMH), lacunae (LA), cerebral microbleeds (CMBs), and visible perivascular spaces (PVS). The burden of cSVD was defined as non, mild, moderate, or severe. Logistic regression was used to estimate the odds ratio (OR) and confidence interval (CI).ResultsHigh SBP variability was associated with moderate cSVD burden (OR=1.89, 95% CI: 1.09-3.29) and PVS (OR= 1.62, 95%CI: 1.10-2.39). The DBP was associated with LA (OR=1.74, 95%CI: 1.06-2.84). The PP showed obvious risk effects on moderate/severe cSVD burden (OR= 1.99, 95%CI: 1.17-3.41; OR=2.49, 1.34-4.63). These associations were modified by age and hypertension status. In the young adults (age<60 years old), only high PP variability associated with severe cSVD burden (OR=3.33, 95%CI: 1.31-8.44), LA (OR=3.02, 95%CI: 1.31-6.93), and PVS (OR=1.86, 95%CI: 1.20-2.88). The risk effect of SBP and PP variability on cSVD burden was only significant in the participants with hypertension.ConclusionHigh long-term BP variability, especially in combination with hypertension, is a risk factor for total cSVD burden, LA, and PVS. it is crucial to pay attention to PP variability in young adults.

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Section: Discussionmentioning

confidence: 99%

Higher long-term visit-to-visit blood pressure variability is associated with severe cerebral small vessel disease in the general population

Zhao,

Ying,

et al. 2024

Preprint

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“…Our longitudinal study examined healthy old people living in a rural town, Takasu, Japan, to investigate clinical and epidemiological aspects of age-related changes in the brain that appeared on CT. Recently we demonstrated an association between longitudinal blood pressure variability and cerebrovascular changes 11 ) . In this report, we examined whether the participants had developed functional dependence over six years, and investigated the association of changes in the ageing brain on subsequent development of functional dependence.…”

Section: Introductionmentioning

confidence: 97%

Cranial Computed Tomography Associated with Development of Functional Dependence in a Community-based Elderly Population.

Tsukishima

Saito

Shido

et al. 2002

Journal of Epidemiology

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Is there a difference in risk factors for single and multiple symptomatic lesions in small vessel disease?

Pavlović¹,

Gazibara²,

Zidverc-Trajković³

et al. 2006

Clinical Neurology and Neurosurgery

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Long-term Blood Pressure Variability and Cerebrovascular Changes on CT in a Community-based Elderly Population.

Cited by 6 publications

References 28 publications

Higher long-term visit-to-visit blood pressure variability is associated with severe cerebral small vessel disease in the general population

Higher long-term visit-to-visit blood pressure variability is associated with severe cerebral small vessel disease in the general population

Cranial Computed Tomography Associated with Development of Functional Dependence in a Community-based Elderly Population.

Is there a difference in risk factors for single and multiple symptomatic lesions in small vessel disease?

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