Long-term blockade of the expression of cocaine sensitization by ondansetron, a 5-HT3 receptor antagonist

King, George; Xiong, Zhiping; Douglass, Scott L.; Ellinwood, Everett H.

doi:10.1016/s0014-2999(99)00926-7

Cited by 66 publications

(35 citation statements)

References 31 publications

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“…Costall et al 1990b;Costall and Naylor 1992; see also Hagan et al 1990Hagan et al , 1993King et al 1994King et al , 1997King et al , 2000. However, the present data indicate that all three 5-HT 3 receptor antagonists studied exerted effects upon the behavior of SAL controls; notably, MDL 72222, Y-25130, fluphenazine+Y-25130 increased hyperactivity from injection 1 to 7 of SAL treatment in a sensitizationlike manner.…”

Section: Discussionmentioning

confidence: 45%

“…To date, no full-length report exists on the long-term consequences of 5-HT 3 R blockade during repeated COC administration, although ondansetron treatment is reported to produce long-term (3 weeks) effects on COC motor sensitization when administered during the week following repeated COC (King et al 2000). Combined, the results of these two studies would suggest that 5-HT 3 receptor activation might contribute to the maintenance of motor sensitization rather than its induction.…”

Section: Discussionmentioning

confidence: 99%

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Pretreatment with serotonin 5-HT3 receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats

2003

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These data indicate the effects of 5-HT(3) receptor antagonists on both acute COC-induced motor behavior and COC-induced motor sensitization are compound-selective. As none of the 5-HT(3) receptor antagonists attenuated the magnitude of the sensitized motor response to COC in the long term, these data also indicate that like DA receptor activation, 5-HT(3) receptor activation is necessary for the full expression of acute COC-induced motor hyperactivity, but it is not required for the development of long-term motor sensitization.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Pretreatment with serotonin 5-HT3 receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats

2003

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“…Drug-induced behavioral sensitization can be divided into three phases which comprises development, transfer, and expression King et al, 2000;Li et al, 2004). The development phase is indicative of transient neuronal maladaptive alterations occurring during the acquisition of sensitization and the expression phase reflects neuronal adaptive alterations evoked by drug exposure.…”

Section: Discussionmentioning

confidence: 99%

Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization

et al. 2016

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“…Local administration of quinpirole into the VTA reduces DA cell firing rates (Jeziorski and White, 1989;Congar et al, 2002). The actions of cocaine appear to be mediated in part through activation of 5-HT3 receptors (King et al, 1995(King et al, , 2000(King et al, , 2002, and the activity of VTA DA neurons appears to be regulated by 5-HT3 receptors (Minabe et al, 1991;Rasmussen et al, 1991;Campbell et al, 1996). Therefore, the involvement of 5-HT3 receptors in cocaine selfinfusion into the VTA was tested by coadministration of a 5-HT3 receptor antagonist.…”

mentioning

confidence: 99%

Intracranial Self-Administration of Cocaine within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons

Rodd

Bell²,

Kuc

et al. 2005

J Pharmacol Exp Ther

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The rewarding properties of cocaine have been postulated to be regulated, in part, by the mesolimbic dopamine (DA) system. The present study assessed whether adult female Wistar rats would self-administer cocaine directly into the ventral tegmental area (VTA). Following guide cannulae surgery aimed at either the posterior or anterior VTA, subjects were placed in an operant box equipped with an active lever that caused the delivery of the infusate and an inactive lever that did not. Posterior and anterior VTA subjects were randomly assigned to one of six groups that self-administered either artificial cerebrospinal fluid (aCSF) or 25 to 400 pmol cocaine/100 nl in aCSF for the first four sessions, aCSF in sessions 5 and 6, and the acquisition dose of infusate during session 7. Additionally, the effects of increasing the time-out period, higher concentrations of cocaine, coadministration of a 5HT 3 antagonist, and coadministration of a D 2/3 agonist on self-infusion of cocaine were determined. Self-infusions were maintained when the time-out period was extended from 5 to 25 s. Coinfusion of a 5HT 3 antagonist or D 2/3 agonist blocked the self-infusion of cocaine. In contrast, rats did not self-administer 25 to 400 pmol/100 nl cocaine into the anterior VTA. Additionally, rats did not selfadminister either 800 or 1600 pmol/100 nl cocaine into the posterior or anterior VTA. Overall, the data indicate that the VTA is functionally heterogeneous with regard to the rewarding actions of cocaine and that the reinforcing effects of cocaine within the posterior VTA are mediated by activation 5-HT 3 receptors and DA neurons.

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Long-term blockade of the expression of cocaine sensitization by ondansetron, a 5-HT3 receptor antagonist

Cited by 66 publications

References 31 publications

Pretreatment with serotonin 5-HT3 receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats

Pretreatment with serotonin 5-HT3 receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats

Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization

Intracranial Self-Administration of Cocaine within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons

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