Long‐term benefits of mindfulness on white matter tracts underlying the cortical midline structures in panic disorder: A 2‐year longitudinal study

Abstract

Aims: We aimed to examine the long-term benefits of mindfulness-based cognitive therapy (MBCT) on white matter plasticity in the cortical midline structures (CMS) for a period of 2 years in patients with panic disorder and the relationships between white matter changes in the CMS and severity of state and trait symptoms.Methods: Seventy-one participants were enrolled and underwent diffusion tensor imaging at baseline and after 2 years (26 who received MBCT as an adjunct to pharmacotherapy [MBCT+PT], 20 treated with pharmacotherapy alone [PT-alone], and 25 healthy controls [HCs]). The severity of symptoms and fractional anisotropy (FA) in white matter regions underlying the CMS were assessed at baseline and 2-year follow-up. Results:The MBCT+PT group showed better outcomes after 2 years than the PT-alone group. The groups showed different FA changes: the MBCT+PT group showed decreased FA in the left anterior cingulate cortex (ACC); the PT-alone group showed increased FA in the bilateral dorsomedial prefrontal cortex, posterior cingulate cortex (PCC), and precuneus. Decreased white matter FA in the ACC, PCC, and precuneus was associated with improvements in the severity of state and trait symptoms in patients with panic disorder. Conclusion:Alleviation of excessive white matter connectivity in the CMS after MBCT leads to improvements in clinical symptoms and trait vulnerability in patients with panic disorder. Our study provides new evidence for the long-term benefits of MBCT on white matter plasticity and its clinical applicability as a robust treatment for panic disorder.

Intervensi Mindfuness Behavior Cognitive Therapy (MBCT) dalam Meningkatkan Self Esteem pada Remaja: Literature Review

“…(Schanche et al, 2021) Dalam penelitiannya mengungkapkan bahwa Ketika terjadi kesalahan atau sesuatu berjalan tidak semestinya, orang-orang yang mengikuti MBCT tampak lebih mampu mentolerir kesalahan, mampu untuk mengendalikan kecenderungan untuk mengkritik diri sendiri, tidak terlalu memikirkan kekurangan diri sendiri, serta merasa tidak teralalu pantas untuk dikritik, (Huang et al, 2019) terjadi penurunan skor secara signifikan pada kesedihan (TRIG), emosi negatif (GAD-7 dan Depresi), dan kesulitan pengaturan emosi (DERS) sedangkan tingkat kesadaran (total skor FFMQ) meningkat secara signifikan. (Bang et al, 2023) MBCT secara signifikan penurunan skor pada gejala panik (Probst et al, 2020) memberikan manfaat bagi pasien depresi kronis yang lebih pendendam/ berpusat pada diri sendiri untuk belajar fokus membuat pengalaman baru dengan proses kognitif dan melaksanakan praktek mindfulness. 8 minggu pelatihan sistematis mampu membawa perubahan dalam kebiasaan lama.…”