Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study

Linde, Cecilia; Leclercq, Christophe; Rex, S.; Garrigue, Stéphane; Lavergne, Thomas; Cazeau, Serge; McKenna, William J.; Fitzgerald, M; Deharo, Jean‐Claude; Alonso, Christine; Walker, S; Braunschweig, Frieder; Bailleul, Christophe; Daubert, Jean‐Claude

doi:10.1016/s0735-1097(02)01932-0

Cited by 832 publications

(446 citation statements)

References 20 publications

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“…Therefore, we have a cohort in whom there was effective mechanical cardiac resynchronization; otherwise, it would have been futile for us to proceed with the pursuit of understanding of any further mechanistic effect of CRT. The lack of statistically significant improvement in VO 2 max was similar to the results of some previously reported CRT studies19, 20 although CRT has also been shown to improve VO 2 max 2. In addition, there was a significant reduction in the plasma concentrations of N‐terminal proBNP, a similar finding to the CARE‐HF trial 2.…”

Section: Discussionsupporting

confidence: 86%

Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?

et al. 2017

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AimsTo evaluate whether peripheral circulatory ‘remodelling’ as measured by changes in vascular compliance and in markers of nitric oxide signalling contributes to patient response to cardiac resynchronization therapy (CRT).Methods and resultsEffects of CRT were evaluated in 33 patients pre‐procedure and 6 months post‐procedure. Peak oxygen consumption, 6 min walk distance, New York Heart Association class, and quality of life score were evaluated. Augmentation index and its interactions with nitric oxide (NO) were evaluated by applanation tonometry. Platelet NO responsiveness and content of thioredoxin‐interacting protein were assessed. Plasma concentrations of N‐terminal proBNP, asymmetric and symmetric dimethylarginine (SDMA), high sensitivity C‐reactive protein, catecholamines, and matrix metalloproteinases‐2 and ‐9 were assessed. Despite significant improvement in 6 min walk distance (P = 0.005), New York Heart Association class (P < 0.001), quality of life (P = 0.001), and all echocardiographic parameters post‐CRT, there were no significant changes in augmentation index measurements, thioredoxin‐interacting protein content, and platelet NO response. Significant falls in N‐terminal proBNP (P = 0.008) and SDMA (P = 0.013; independent of renal function) occurred. Falls in SDMA predicted reduction in high‐sensitivity C‐reactive protein (P = 0.04) and increases in peak oxygen consumption (P = 0.04). There were no correlations between changes in echocardiographic parameters and those in vascular function.ConclusionsThese data suggest that the beneficial effects of CRT over 6 months are independent of any change in peripheral NO‐related signalling. However, there is evidence that suppression of inflammation occurs, and its magnitude predicts extent of clinical improvement.

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Section: Discussionsupporting

confidence: 86%

Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?

et al. 2017

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“…However, in almost all randomized clinical trials, these results were demonstrated in selected patients, with few older patients enrolled [4][5][6]. As a result, it is still not completely clear whether elderly patients respond less favorably or not to CRT as compared with younger patients.…”

Section: Introductionmentioning

confidence: 99%

Cardiac resynchronization therapy is effective even in elderly patients with comorbidities

António

Lourenço

Teixeira

et al. 2009

J Interv Card Electrophysiol

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Purpose The purpose of this study was to compare the effects of cardiac resynchronization therapy (CRT) in elderly patients (≥65 years) with younger patients and to assess the impact of comorbidities in CRT remodeling response. Methods This is a prospective study of 87 consecutive patients scheduled for CRT who underwent clinical and echocardiographic evaluation before and 6 months after CRT. A reduction in left ventricular end-systolic volume (LVESV) ≥15% after CRT defined remodeling responders, and a reduction of at least one New York Heart Association class defined clinical responders. Multivariate analysis was used to identify independent predictors of non-response to CRT in terms of reverse remodeling. Results The mean age was 62±11 years, with 36 elderly patients (41%). The baseline QRS duration was 145± 32 ms. After CRT, there were significant and similar improvements of left ventricular (LV) ejection fraction, LVESV, LV dP/dt, and mitral regurgitation jet area (JA) between elderly (≥65 years) and younger (<65 years) patients. The number of clinical and remodeling responders was comparable, and we found no significant differences in unplanned cardiac hospitalizations at 6 months between groups. Independent predictors of lack of remodeling response to CRT were QRS duration <120 ms, LV diastolic diameter >74 mm, and JA >10 cm 2 before CRT, but not comorbidities.Conclusion This work suggests that being elderly is not an impediment to CRT success even in the presence of comorbidities.

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“…For decades, implantable cardiac pacemakers and defibrillators have been in widespread clinical use and have proven efficacious in the long-term treatment of many cardiac disorders [1,50,71]. Recently, this technology has been adapted by Mueller et al to serve as a laryngeal pacemaker system implanted directly into laryngeal muscles in patients with bilateral vocal fold paralysis to improve breathing and swallowing, without compromising vocalization [94].…”

Section: Muscle Stimulationmentioning

confidence: 99%

Interfacing with the nervous system: a review of current bioelectric technologies

et al. 2017

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The aim of this study is to discuss the state of the art with regard to established or promising bioelectric therapies meant to alter or control neurologic function. We present recent reports on bioelectric technologies that interface with the nervous system at three potential sites-(1) the end organ, (2) the peripheral nervous system, and (3) the central nervous system-while exploring practical and clinical considerations.

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Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study

Abstract: The clinical benefits of BiV pacing appeared to be significantly maintained over a 12-month follow-up period.

Cited by 832 publications

References 20 publications

Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?

Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?

Cardiac resynchronization therapy is effective even in elderly patients with comorbidities

Interfacing with the nervous system: a review of current bioelectric technologies

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