Long-term assessment of contrast effects of gadofluorine M and gadofluorine P in magnetic resonance imaging of mice

Abstract

Both gadofluorine M and gadofluorine P appear to be applicable to blood pool imaging and liver imaging in mice.

Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA

“…First, Gadofluorine P has a strong blood pool effect [23] . Unlike Gd-DOTA, which is also T1 contrast media but is rapidly cleared from the intravascular space and eliminated [32] , Gadofluorine P can re-circulate in the blood by binding to albumin via its nonspecific protein binding properties [19] .…”

“…In mice, contrast enhancement in the blood almost disappeared 6 h after the injection of Gadofluorine P, whereas it was 24 h for Gadofluorine M [23] . Gd-DOTA is a macrocyclic gadolinium paramagnetic complex with a molecular weight of approximately 558 g/mol ( Figure 2) [24] .…”

“…The 6 diabetic rats and the 5 controls underwent MRI for 3 d. We performed MRI first with Gd-DOTA and 24 h later with Gadofluorine P because the elimination half-life of Gd-DOTA is much shorter than that of Gadofluorine P [19,25] . The imaging time point for Gd-DOTA and Gadofluorine P was based on our time-intensity curve data ( Figure 3) and data from other studies [13,23] . The rats were scanned in the supine position with no respiratory gating.…”