Long-term antibody response following SPUTNIK V primary vaccination in healthcare workers with and without history of SARS-CoV-2 infection: Prospective cohort study from a hospital in Argentina

Longitudinal Follow-Up of the Immunity to SARS-CoV-2 in Health Care Workers in Argentina: Persistence of Humoral Response and Neutralizing Capacity after Sputnik V Vaccination

“…Correlation of anti-Spike/RBD antibody levels and neutralizing antibody titers was previously reported ( 6 to 12 ). Here, we evaluated correlation in the Non-COVID group by analyzing levels of specific antibodies and neutralizing antibodies against ancestral SARS-CoV-2.…”

“…However, data on maintenance of seropositivity is divergent. Although seroprevalence after 2 to 3 weeks after second dose is generally 97 to 99%, some works showed that seropositivity decreased over a 6-month period to 83% ( 6 ) and even to 31% ( 11 ), whereas some others reported a maintenance of seropositivity in around 95% of the analyzed cohort ( 7 , 9 , 12 ).…”

“…Hybrid immunity resulting from SARS-CoV-2 infection either prior to or after COVID-19 vaccination has been associated with broader protection, higher levels of neutralizing antibodies, and greater protection against symptomatic infection compared to immunity after vaccination or infection alone ( 14 , 15 ). It was previously shown that total ( 6 , 10 , 11 , 16 , 17 ) and neutralizing ( 10 , 11 , 16 ) antibody response after Sputnik V vaccination is enhanced in previously infected individuals.…”

“…Waning of the antibody response against SARS-CoV-2 over time after vaccination has been well documented for the different vaccine platforms and, together with emergence of variants of concern (VOCs) associated with higher incidence of breakthrough infections, has hampered the control of the pandemic ( 4 , 5 ). For Sputnik V vaccine, multiple reports have shown that anti-S/RBD antibody levels decreased over a period of approximately 6 months after complete vaccination (two doses with a 21-days interval between doses) ( 6 to 10 ). However, data on maintenance of seropositivity is divergent.…”

Infant vaccination against pertussis in Argentina: Parent-reported outcomes on reactogenicity, impact on daily routine and satisfaction after pentavalent whole-cell or hexavalent acellular pertussis vaccines

“…These findings are comparable to those of another study in a similar population showing high vaccine confidence levels among parents. [19] In general, vaccine acceptance is high among the population in Argentina and in Latin America where anti-vaccine movements are weak. [20] It is important to point out that NIP vaccination is mandatory in our country which can explain why so many participants responded “to comply with the immunization schedule”.…”