Long-term and short-term duration of thienopyridine therapy after coronary stenting in patients with chronic kidney disease a meta-analysis of literature studies

Wu, Yu; Song, Yimiao; Pan, Yuesong; Gong, Yanchun; Zhou, Yilun

doi:10.1080/09537104.2019.1647528

Cited by 2 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Meanwhile, some studies also show that prolonged use of P2Y12 inhibitors further lower the risk of death and stent thrombosis, while others suggest extended dual antiplatelet treatment (DAPT) does not bring extra clinical benefit but increase risk of bleedings. [29][30][31] These findings suggest there is still heterogeneity within the high-risk patients of renal impairment. On top of kidney disease, age-adjusted elevation of D-dimer might serve as an indicator to identify patients at higher risk who are potentially suitable for prolonged DAPT or even anticoagulation, while standard 12-month DAPT or deescalated monotherapy could be considered for those without hypercoagulative status.…”

Section: Dovepressmentioning

confidence: 93%

Prognostic Value of Age-Adjusted D-Dimer Cutoff Thresholds in Patients with Acute Coronary Syndrome Treated by Percutaneous Coronary Intervention

Chen¹,

Liu²,

Zhou

et al. 2022

CIA

View full text Add to dashboard Cite

Background: Associations between D-dimer and outcomes of patients with acute coronary syndrome (ACS) remain controversial. Using age-adjusted D-dimer cutoff thresholds improve the diagnostic accuracy for thrombotic diseases. This study aimed to investigate the prognostic value of age-adjusted D-dimer in ACS patients treated by percutaneous coronary intervention (PCI). Methods: A total of 3972 consecutive patients with ACS treated by PCI were retrospectively recruited. The basal age-adjusted D-dimer threshold was 500 ng/mL and was calculated as age × 10 in patients older than 50 years. Cox regression was used for outcome analysis. C-index, net reclassification index (NRI), and integrated discrimination improvement (IDI) were calculated to assess the additional prognostic value of age-adjusted D-dimer when combined with established clinical risk factors. The primary outcome was all-cause death. Results: During a median follow-up of 720 days, a total of 225 deaths occurred. High D-dimer level, as defined by age-adjusted thresholds, was an independent predictor for all-cause death (hazard ratio [

show abstract