Long-term Analysis of Pigmentary Dispersion Syndrome and Piegmentary Glaucoma

Migliazzo, Carl; Shaffer, Robert N.; Nykin, Raisa; Magee, Scott

doi:10.1016/s0161-6420(86)33526-7

Cited by 98 publications

(63 citation statements)

References 8 publications

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“…The actual rate of conversion from PDS to PG is still a matter of debate. Migliazzo et al 11 described 35% of patients with PDS and ocular hypertension developing disc and field changes over a mean follow-up of 17.3 years. Farrar et al, 8 while following a group of patients affected by PDS or PG, showed a 50% conversion rate over a mean follow-up of 4.3 years.…”

Section: Discussionmentioning

confidence: 99%

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A 10-Year Follow-up to Determine the Effect of YAG Laser Iridotomy on the Natural History of Pigment Dispersion Syndrome

et al. 2014

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Prospective long-term analyses of the role of drug-induced mydriasis and laser peripheral iridotomy (LPI) are needed to identify and manage the eyes of patients with pigment dispersion syndrome (PDS) at risk for progressing to ocular hypertension.OBJECTIVE To assess the 10-year incidence of increased intraocular pressure (IOP) in the 2 eyes of patients with PDS, with 1 eye that underwent LPI and the other that did not. DESIGN, SETTING, AND PARTICIPANTSIn a randomized clinical trial in the glaucoma research unit at the University Hospital of Parma, Italy, 72 patients with PDS underwent phenylephrine testing. Of these 72 patients, 29 (58 eyes) tested positive for succeeding IOP elevation, and 43 (59 eyes) tested negative. For the 29 high-risk patients (all in both eyes), one eye was randomly assigned to LPI, and the fellow eye was left untreated. For the 43 low-risk patients, the affected eyes were left untreated.MAIN OUTCOMES AND MEASURES An IOP elevation of 5 mm Hg or higher vs baseline (daily phasing) was considered to be a significant increase (ie, an event). RESULTSIn the high-risk group, 3 of 21 eyes that underwent LPI (14.3%) and 13 of 21 untreated eyes (61.9%) showed an increase in IOP of 5 mm Hg or higher during the follow-up period; 4 of 35 low-risk eyes (11.4%) showed a similar increase. Event-free mean (SD) time was 7.99 (0.43) years for high-risk treated eyes, 3.89 (0.68) years for high-risk untreated eyes, and 7.16 (0.23) years for low-risk eyes. The log-rank test showed the following: P < .001 for treated high-risk eyes vs untreated high-risk eyes, P = .74 for treated high-risk eyes vs low-risk eyes, and P < .001 for untreated high-risk eyes vs low-risk eyes.CONCLUSIONS AND RELEVANCE At the end of the 10-year follow-up, (1) approximately one-third of the whole PDS patient population showed an IOP increase of 5 mm Hg or higher in at least 1 eye; (2) phenylephrine testing identified eyes at high risk for developing IOP elevation; and (3) LPI, when performed on high-risk eyes, reduced the rate of IOP elevation to the same level as the low-risk eyes.TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01053416

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Section: Discussionmentioning

confidence: 99%

“…However, a tentative summary is shown in Figure 3. 8,11,[16][17][18] Determining which eye affected by PDS will eventually develop PG can be difficult. "Active" pigment dispersion (ie, the detection over time of an increased amount of pigment deposition on anterior segment structures) seems to be a major risk factor for conversion.…”

Section: Discussionmentioning

confidence: 99%

A 10-Year Follow-up to Determine the Effect of YAG Laser Iridotomy on the Natural History of Pigment Dispersion Syndrome

et al. 2014

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“…Pigmentary glaucoma is most commonly diagnosed in the third and fourth decades of life though the age of onset is uncertain (Speakman 1981). Males present with a diagnosis of pigmentary glaucoma at an earlier age compared to females (Migliazzo 1986;Scheie 1981;Sugar 1966). Young age, male gender and myopia have been found to be significant risk factors associated with the development of pigmentary glaucoma (Migliazzo 1986;Richter 1986).…”

Section: Epidemiologymentioning

confidence: 99%

“…Males present with a diagnosis of pigmentary glaucoma at an earlier age compared to females (Migliazzo 1986;Scheie 1981;Sugar 1966). Young age, male gender and myopia have been found to be significant risk factors associated with the development of pigmentary glaucoma (Migliazzo 1986;Richter 1986). Pigmentary glaucoma was reported to occur in 35%, 50%, and 10% after five years of follow up, and in 15% after 15 years of follow up in different retrospective studies (Farrar 1989;Migliazzo 1986;Siddiqui 2003).…”

Section: Epidemiologymentioning

confidence: 99%

“…Young age, male gender and myopia have been found to be significant risk factors associated with the development of pigmentary glaucoma (Migliazzo 1986;Richter 1986). Pigmentary glaucoma was reported to occur in 35%, 50%, and 10% after five years of follow up, and in 15% after 15 years of follow up in different retrospective studies (Farrar 1989;Migliazzo 1986;Siddiqui 2003). However, one prospective study reported pigmentary glaucoma in 18% of participants with pigmentary dispersion syndrome (Richter 1986).…”

Section: Epidemiologymentioning

confidence: 99%

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