Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence

Tsuji, Ryohei; Komano, Yuta; Ohshio, Konomi; Ishii, Naoaki; Kanauchi, Osamu

doi:10.1016/j.exger.2018.06.028

Cited by 19 publications

(9 citation statements)

References 42 publications

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“…Supplementation of Lactococcus lactis subsp. lactis strain Plasma reduced the expression of genes associated with muscle degeneration and decelerated senescence ( 25 ). Moreover, consumption of Lactobacillus paracasei PS23 attenuated aging-related cognitive decline and muscle loss ( 26 , 27 ).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice

Lee¹,

Liao

Lee

et al. 2021

Front. Nutr.

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In humans, aging is characterized by the progressive decline in biological, physiological, and psychological functions, and is a major risk factor in the development of chronic diseases. Therefore, the development of strategies aimed at attenuating aging-related disorders and promoting healthy aging is critical. In a previous study, we have demonstrated that Lactobacillus plantarum TWK10 (TWK10), a probiotic strain isolated from Taiwanese pickled cabbage, improved muscle strength, exercise endurance, and overall body composition in healthy humans. In this study, the effect of TWK10 on the progression of age-related impairments was investigated in mice. We found that TWK10 not only enhanced muscle strength in young mice, but also prevented the aging-related loss of muscle strength in aged mice, which was accompanied by elevated muscle glycogen levels. Furthermore, TWK10 attenuated the aging-associated decline in learning and memory abilities, as well as bone mass. Further analyses of gut microbiota using next-generation sequencing (NGS) of the 16S rRNA gene showed that the pattern of gut microbial composition was clearly altered following 8 weeks of TWK10 administration. TWK10-treated mice also experienced an increase in short-chain fatty acid (SCFA)-producing bacteria and higher overall levels of gut SCFA. Furthermore, TWK10 administration to some extent reversed the aging-associated accumulation of pathogenic bacterial taxa. In conclusion, TWK10 could be viewed as a potential therapeutic agent that attenuates aging-related disorders and provides health benefits by modulating the imbalance of gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice

Lee¹,

Liao

Lee

et al. 2021

Front. Nutr.

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“…lactis strain Plasma to senescence-accelerated mice strains Prone 1 (SAMP1) and Prone 10 (SAMP10) activated the IFN-α induction activity in SAMP1, and reduced the aging-related skin thinning, improved the naïve T cell ratio, increased the expression of tight junction-related genes (Claudin-1 and Zo-1), and suppressed the expression of muscle degeneration gene (FoxO-1) in SAMP10. Overall, the senescence score was reduced in the probiotic-supplemented group when compared with the respective controls [62].…”

Section: Anti-aging Property Of Probioticsmentioning

confidence: 85%

A Review on Anti-Aging Properties of Probiotics

2018

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Aging is the inevitable biological event associated with several physiological, behavioral, and lifestyle events, but people do not wish to become old. The market for anti-aging products is growing gradually, and customers are aware of active principles in the cosmetics. The probiotics are known for several health benefits; especially probiotics regulate the gut health and immune system. Recent studies emphasized the role of probiotics, and probiotic-containing fermented products in cosmetics, and aging. The whole mechanism of aging has not been elucidated yet, but modern aging theories are in two different categories such as programmed theory and damage theory. The aging mechanisms can be discussed in organismal, and cellular level. To some extent, organismal and premature aging is controlled by genetic makeup. Though genetic, and environmental factors impact healthy aging, diet and gut microbiota also play a significant role in senescence. Aging is greatly associated with a diversity of gut microbiota that is often related to the changes in the gastrointestinal tract, and dietary patterns, together with an associated decline in cognitive and immune function, eventually contributing to infirmity. Lactic acid bacteria are reported for the ability to extend the lifespan and/or healthspan. The current manuscript discussed the aging mechanisms, an association of microbiome and aging, and compiled the reported anti-aging properties of probiotics.

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“…In addition to periodic, midface, and perioral aging changes, the study also showed that preauricular area was of great value when assessing the need for facial contouring procedures 15 . More importantly, probiotics reportedly interfere with skin aging and the development of atopic dermatitis, allergic rhinitis, and wound healing in rodents/humans 16,17 . Although the details of the mechanism by which oral probiotics improve skin condition are unclear, some researchers have proposed that it may involve the restoration of the pH value of the skin to its normal range (4.2–5.6) and the inhibition of protease activity in aged skin possibly by inhibiting inflammatory activities 18 .…”

Section: Introductionmentioning

confidence: 86%

“…15 More importantly, probiotics reportedly interfere with skin aging and the development of atopic dermatitis, allergic rhinitis, and wound healing in rodents/humans. 16,17 Although the details of the mechanism by which oral probiotics improve skin condition are unclear, some researchers have proposed that it may involve the restoration of the pH value of the skin to its normal range (4.2-5.6) and the inhibition of protease activity in aged skin possibly by inhibiting inflammatory activities. 18 For example, Lactobacillus plantarum can reduce the skin wrinkles and downregulate the expression of MMPs-2, MMPs-9, and MMPs-13 in UVB-irritated mice, and its clinical benefits of reduced wrinkling and increased brightness and hydration of human skin had been verified.…”

Section: Introductionmentioning

confidence: 99%

The potential of Streptococcus thermophiles (TCI633) in the anti‐aging

Liu

Tseng

Chan

et al. 2021

J of Cosmetic Dermatology

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Background Streptococcus thermophilus (TCI633) is a probiotic that has been newly isolated from human breast milk, and it can produce hyaluronic acid (HA) when colonizing the gastrointestinal (GI) tract of rodents and humans. A recent study has the established that TCI633 can alleviate synovial tissue inflammation and has potential to mitigate the progression of osteoarthritis. Objective TCI633 has not been available for use in skincare and this preliminary clinical study will assess its improvement of the skin. Methods In this study, DNA protection, Hyaluronidase assay, cell viability, and collagen synthesis on human fibroblasts of TCI633 were assessed. Subjects were enrolled in this clinical study and randomly assigned to the TCI633 or placebo group. Each subject was informed to intake two tablets daily for 8 weeks. Each subject was required to undergo skin condition inspection at weeks 0, 4, and 8 and hematology tests to monitor HA, superoxide dismutase (SOD) and catalase levels, and kidney and liver function at weeks 0 and 8. Results The effects of TCI633 supplementation, including the promotion of skin cell proliferation, the increase of their collagen content, their protection against DNA damage, and the inhibition of hyaluronidase activities, are investigated. Subjects were recruited for an 8‐week long clinical trial to confirm the efficacy of TCI633 in improving the serum biochemical HA, SOD and catalase levels, and anti‐skin age markers. Conclusions This work provides an alternative approach to improving health, indicating the potential of TCI633 supplementation to delay the aging of skin and improve its condition.

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Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence

Cited by 19 publications

References 42 publications

Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice

Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice

A Review on Anti-Aging Properties of Probiotics

The potential of Streptococcus thermophiles (TCI633) in the anti‐aging

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