Long-term administration of immunoglobulin in a patient with anti-SRP immune-mediated necrotizing myopathy

Pinheiro, F. Oliveira; Madureira, P.; Rato, M.; Costa, Lúcia

doi:10.5114/reum.2022.123675

Cited by 2 publications

(1 citation statement)

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“…50 Two case reports described the successful treatment of recurrent pericarditis in SLE with anakinra. 51,52 Anakinra has been showed to be effective also in a patient with adult onset Still disease and myopericarditis resistant to tocilizumab. 53 More studies are required to highlight the potential benefit of anakinra in patients with recurrent pericarditis and autoimmune diseases.…”

Section: The Nlrp3 Inflammasome/il-1b Axis As a Central Player In Per...mentioning

confidence: 99%

Novel Therapeutic Insights Into the Treatment of Pericarditis: Targeting the Innate Immune System

Vecchié,

Bonaventura,

Golino

et al. 2024

Journal of Cardiovascular Pharmacology

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Acute pericarditis is characterized by pericardial inflammation which can be treated with anti-inflammatory drugs. A considerable percentage of patients develops recurrent pericarditis with several relapses. In developed countries, the idiopathic form is the most frequent and has a high risk of recurrences. Two pathophysiological mechanisms have been described for idiopathic recurrent pericarditis, autoimmune and autoinflammatory. The autoimmune mechanism is more frequently encountered in patients with rheumatologic disorders, especially systemic lupus erythematosus. The innate immune system plays a central role in the pathophysiology of pericarditis, especially in the autoinflammatory phenotype. Current evidence highlights the central role played by interleukin 1 (IL-1) and NLRP3 (NACHT, leucine-rich repeat, and pyrin domain-containing protein 3) in idiopathic recurrent pericarditis. Accordingly, IL-1 blockers have been approved for the treatment of this condition. Neutrophils are likely to be important in such setting, however their role has only been partially investigated. In the present review we have collected the current knowledge on the role of innate immune system in pericarditis pathophysiology and how this can be used to provide targeted treatments for patients with recurrent pericarditis.

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Section: The Nlrp3 Inflammasome/il-1b Axis As a Central Player In Per...mentioning

confidence: 99%

Novel Therapeutic Insights Into the Treatment of Pericarditis: Targeting the Innate Immune System

Vecchié,

Bonaventura,

Golino

et al. 2024

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

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Azathioprine

2023

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Long-term administration of immunoglobulin in a patient with anti-SRP immune-mediated necrotizing myopathy

Cited by 2 publications

References 5 publications

Novel Therapeutic Insights Into the Treatment of Pericarditis: Targeting the Innate Immune System

Novel Therapeutic Insights Into the Treatment of Pericarditis: Targeting the Innate Immune System

Azathioprine

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