Long-term add-on Yoga therapy offers clinical benefits in major depressive disorder by modulating the complement pathway: A randomized controlled trial

Subbanna, Manjula; Talukdar, Pinku Mani; Abdul, Fazal; Debnath, Monojit; Reddy, Preethi V; Arasappa, Rashmi; Venkatasubramanian, Ganesan; Muralidharan, Kesavan; Gangadhar, Bangalore N.; Bhargav, Praerna Hemant; Karmani, Sneha

doi:10.1016/j.ajp.2021.102876

Cited by 7 publications

(30 citation statements)

References 10 publications

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“…Intensity of intervention is another potential reason for the positive findings in the other studies. Compared to the 1.5 hr/session a week for 9 weeks in the present study, the studies with positive findings all had more intensive interventions—three 20–30-min sessions in 3 days in Broota and Dhir (1990), 2 hr/session, five sessions per week for 12 weeks in Tolahunase et al (2018), or four-to-six 1-hr sessions per week for 3 months in Subbanna et al (2021). Another indication of the less intensive nature of our intervention is that the participants showed relatively low amounts of home practice.…”

Section: Discussionmentioning

confidence: 52%

“…Two of these studies had similar findings to ours with no group differences between the yoga group and the control group (Ravindran et al, 2021; Sarubin et al, 2014). The other four studies found a significant difference in decrease of symptoms of depression in favor of the yoga group (Broota & Dhir, 1990; Falsafi, 2016; Subbanna et al, 2021; Tolahunase et al, 2018). A potential explanation for the discrepancy with our findings might relate to differences in the TAU that was offered to the participants.…”

Section: Discussionmentioning

confidence: 93%

“…This study examined the efficacy of MYI by adding it to TAU for young women with MDD. Regarding the addition of a yoga intervention to TAU, we found six other studies that compared TAU-only with yoga plus TAU (Broota & Dhir, 1990; Falsafi, 2016; Ravindran et al, 2021; Sarubin et al, 2014; Subbanna et al, 2021; Tolahunase et al, 2018). Two of these studies had similar findings to ours with no group differences between the yoga group and the control group (Ravindran et al, 2021; Sarubin et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…However, the exact nature of TAU in these yoga trials is often unclear, which is more generally a problem for behavioral intervention research (Freedland et al, 2011). Studies investigating yoga interventions in MDD patients who currently received some form of standard treatment are scarce—we found only six such trials (Broota & Dhir, 1990; Falsafi, 2016; Ravindran et al, 2021; Sarubin et al, 2014; Subbanna et al, 2021; Tolahunase et al, 2018). In five of these trials, TAU was limited to the use of medication (Broota & Dhir, 1990; Ravindran et al, 2021; Sarubin et al, 2014; Subbanna et al, 2021; Tolahunase et al, 2018).…”

Section: Evidence For Mindful Yoga As a Treatment For Depressionmentioning

confidence: 99%

“…Studies investigating yoga interventions in MDD patients who currently received some form of standard treatment are scarce—we found only six such trials (Broota & Dhir, 1990; Falsafi, 2016; Ravindran et al, 2021; Sarubin et al, 2014; Subbanna et al, 2021; Tolahunase et al, 2018). In five of these trials, TAU was limited to the use of medication (Broota & Dhir, 1990; Ravindran et al, 2021; Sarubin et al, 2014; Subbanna et al, 2021; Tolahunase et al, 2018). In one trial, only some of the participants received some form of TAU (medication or psychotherapy), and it was unclear whether these percentages differed between the yoga and control group (Falsafi, 2016).…”

Section: Evidence For Mindful Yoga As a Treatment For Depressionmentioning

confidence: 99%

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Mindful yoga intervention as add-on to treatment as usual for young women with major depressive disorder: Results from a randomized controlled trial.

Vollbehr¹,

Hoenders²,

Bartels-Velthuis³

et al. 2022

Journal of Consulting and Clinical Psychology

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Objective: To examine the added value of a 9-week mindful yoga intervention (MYI) as add-on to treatment as usual (TAU) in reducing depression for young women (18-34 years) with major depressive disorder (MDD). Method: Randomized controlled trial (RCT; n = 171) comparing TAU + MYI with TAU-only. Assessments were at baseline, postintervention, and at 6-and 12-month follow-up. Primary outcome measures were clinician-rated and self-reported symptoms of depression, together with a diagnostic interview to establish MDD diagnosis that was restricted to the baseline and 12-month follow-up assessments. Quality of life in various domains was assessed as secondary outcome measure. As potential mediators for treatment efficacy, we included self-report measures of rumination, self-criticism, self-compassion, intolerance of uncertainty, perceived body awareness and dispositional mindfulness, together with behavioral measures of attentional bias (AB) and depression-related self-associations. Results: Adding MYI to TAU did not lead to greater reduction of depression symptoms, lower rate of MDD diagnosis or increase in quality of life in various domains of functioning at post and follow-up assessments. There were no indirect effects through any of the potential mediators, with the exception of self-compassion. Conclusion: Adding MYI to TAU appeared not more efficacious than TAU-only in reducing depression symptoms in young women.What is the public health significance of this article? Overall, this study suggests that adding a mindful yoga intervention to treatment as usual for young women with depression does not lead to increased benefits in terms of stronger reduction in symptoms of depression, lower rate of major depressive disorder diagnosis, or better quality of life within various domains of functioning.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Evidence For Mindful Yoga As a Treatment For Depressionmentioning

confidence: 99%

Section: Evidence For Mindful Yoga As a Treatment For Depressionmentioning

confidence: 99%

See 3 more Smart Citations

Mindful yoga intervention as add-on to treatment as usual for young women with major depressive disorder: Results from a randomized controlled trial.

Vollbehr¹,

Hoenders²,

Bartels-Velthuis³

et al. 2022

Journal of Consulting and Clinical Psychology

View full text Add to dashboard Cite

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Need for Systematic Development and Validation of Yoga Modules in Yoga Research

Jasti,

Gowrapura Halappa,

Bhargav

et al. 2023

Annals of Neurosciences

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Biomarkers of Response to Adjunctive Yoga-Based Interventions in Depression: A Scoping Review

Rajkumar

2024

Preprint

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Depression is the commonest mental disorder worldwide. Both antidepressants and psychotherapy are effective in treating depression, but response to these treatments is often incomplete. Yoga-based interventions (YBIs) have emerged as a promising adjunctive treatment for depression. Recent research has attempted to identify the biological mechanisms associated with the antidepressant actions of YBIs. In this scoping review, conducted according to the PRISMA-ScR guidelines, the PubMed and Scopus databases were searched to retrieve research on biomarkers of response to YBIs in patients with depression. Eleven studies were included in the review. Based on these studies, YBIs may improve depression through beneficial effects on systemic inflammation, stress axis regulation, cardiac autonomic functioning, and possibly reductions in oxidative stress-related cellular damage. Increases in brain-derived neurotrophic factor (BDNF) may represent a final common pathway upon which these processes converge. Though these results are theoretically plausible, they should be interpreted with caution due to certain methodological limitations in the existing research. Replication of these results and improvements in study methodology, and the evaluation of other biomarkers relevant to the pathophysiology of depression, could further elucidate the mechanism of action of YBIs in this disorder, and identify which patients would benefit most from this treatment approach.

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Long-term add-on Yoga therapy offers clinical benefits in major depressive disorder by modulating the complement pathway: A randomized controlled trial

Cited by 7 publications

References 10 publications

Mindful yoga intervention as add-on to treatment as usual for young women with major depressive disorder: Results from a randomized controlled trial.

Mindful yoga intervention as add-on to treatment as usual for young women with major depressive disorder: Results from a randomized controlled trial.

Need for Systematic Development and Validation of Yoga Modules in Yoga Research

Biomarkers of Response to Adjunctive Yoga-Based Interventions in Depression: A Scoping Review

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