Long-Term Accidental Overdose of Levetiracetam in an Infant

Özkale, Yasemin; Özkale, Murat; Saygı, Semra; Erol, İlknur

doi:10.1177/0883073813480560

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…Adverse effects were not observed in infant and children following LEV overdose. 11,12 Sarfaraz et al 13 also detected no neurologic, cardiovascular or gastrointestinal adverse effects in an adult who ingested 600 g LEV and 1.5 g topiramate in a suicide attempt. By contrast, Barrueto et al intubated an adult due to impaired consciousness after ingestion of 30 g LEV and reported a global decrease in DTRs and muscle tone.…”

Section: Discussionmentioning

confidence: 97%

Electrocardiography abnormality in a suicide attempt with levetiracetam

Cömertpay¹,

Say²,

Eroğlu³

et al. 2021

NeuroAsia

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We present a case of suicide attempt with levetiracetam (LEV) in an epilepsy patient. Multifocal ventricular contractions were observed together with bradycardia in this patient due to LEV overdose. Reported patient of LEV overdose in the literature rarely show electrocardiography findings. Although LEV is less toxic than other antiseizure medications, clinicians should be aware of its potential cardiac side effects.

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Section: Discussionmentioning

confidence: 97%

Electrocardiography abnormality in a suicide attempt with levetiracetam

Cömertpay¹,

Say²,

Eroğlu³

et al. 2021

NeuroAsia

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“…25 Ozkale et al described in another study that a high dose of 300 mg/kg/d of LEV was given to a patient accidently for 35 days, no side effects were reported in the patient. 26 Shahid Mahmud and Syed Qamar Zaman stated that among children, they found 58% of them with generalized seizure and 32% with focal seizures. 27 Statistics showed that there was significant relation between age group types of seizures (p=0.046); accurate dosage of antiepileptic drugs and seizures management (p=0.007); medication adherence and management of seizures (p=0.007).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Levetiracetam in Refractory Seizures in Children

Rehman¹,

Noureen²,

Basit³

et al. 2022

PJMHS

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Objective: To assess efficacy and safety of Levetiracetam (LEV) as add-on therapy in children with refractory seizure. Methodology: This prospective observational cohort study was conducted in the Outpatient Department of Paediatric Neurology, “The Children’s Hospital & Institute of Child Health, Multan”, Pakistan from 15th January 2020 to 14th January 2021. Fifty children of aged 2 months to 14 years of both genders with refractory epilepsy were enrolled and received oral LEV. Data on LEV efficacy and side effects were recorded. The medication was considered as “effective” when all seizures had ceased within 3 months, “partially effective” when seizure frequency was decreased by ≥50% and “ineffective” when seizure frequency was decreased by < 50%.or seizure frequency remain unchanged during a period of 3 month. Results: Out of a total of 50 participants, there were 35 (70.0%) male. Mean age was 4.81±3.79 years while mean age at onset of seizures was 2.51±2.85 years. Most frequent type of seizures was generalized tonic clonic seizures in 19 (38.0%) patients followed by focal clonic seizures in 13 (26.0%) patients. Levetiracetam was effective in 14 (28%) patients, partially effective in 24 (48.0%) and not effective in 12 (24.0%) patients. Conclusion: Levetiracetam as add-on therapy reduced the seizure frequency in 76% of the participants without any significant side effects. Keywords: Levetiracetam, refractory seizure, epilepsy, add-on therapy, efficacy.

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“…Children on polytherapy have a greater risk of adverse events than those receiving monotherapy [22]. Ozkale et al [23] reported an infant who was accidentally administered 300 mg/kg/ d for 35 days by her mother. The patient showed no adverse effects after received a high and long-term dose of levetiracetam.…”

Section: Discussionmentioning

confidence: 99%