Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8

Yan, Wu; Chen, Guihai; Wang, Fang; Tong, Jing-Jing; Tao, Fei

doi:10.1016/j.brainres.2015.01.042

Cited by 30 publications

(21 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we found a reduction of H4K8ac in cell layers of three hippocampal subregions in the O-con mice, compared to the Y-con mice. This age-related reduction of H4K8ac was in accordance with our recently published results from SAMP8 mice Yan et al 2015). Excitingly, the gestational LPS exposure augmented this age-related reduction of H4K8ac levels in the older hippocampi, especially in the higher doses, suggesting that declining H4K8 acetylation might play an important role in the underlying mechanism of how LPS exposure during pregnancy accelerates AAMI.…”

Section: Lps Exposure During Pregnancy Intensified H4k8ac Reduction Isupporting

confidence: 91%

“…Specifically, H4 acetylation on the K8 site (H4K8ac) is involved in the formation of long-term memories (Intlekofer et al 2013;McQuown et al 2011). Recently, our studies have also indicated that the oral long-term administration of acarbose or 1-Deoxynojirimycin can alleviate age-related impairments related to spatial learning and memory in SAMP8 mice Tong et al 2015), and the increased H4K8ac may be associated with this alleviation Yan et al 2015).…”

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Wang

Chen

et al. 2016

AGE

Self Cite

View full text Add to dashboard Cite

Data shows that inflammation during pregnancy significantly exerts a long-term influence on offspring, such as increasing the risk of adult cognition decline in animals. However, it is unclear whether gestational inflammation affects the neurobehavioral and neurobiochemical outcomes in the motherself during aging. In this study, pregnant CD-1 mice intraperitoneally received lipopolysaccharide (LPS) in two doses (25 and 50 g/kg, respectively) or normal saline daily during gestational days 15-17. At the age of 15 months, a battery of behavioral tasks was employed to evaluate their species-typical behaviors, sensorimotor ability, anxiety levels, and spatial learning and memory abilities. An immunohistochemical method was utilized preliminarily to detect neurobiochemical indicators consisting of amyloid-β, p h o s p h o r y l a t e d t a u , p r e s y n a p t i c p r o t e i n s synaptotagmin-1 and syntaxin-1, glial fibrillary acidic protein (GFAP), and histone-4 acetylation on the K8 site (H4K8ac). The behavioral results showed that LPS exposure during pregnancy exacerbated a decline in 15-month-old CD-1 mice's abilities to nest, their sensorimotor and spatial learning and memory capabilities, and increased their anxiety levels. The neurobiochemical results indicated that gestational LPS exposure also intensified age-related hippocampal changes, including increased amyloid-β 42 , phosphorylated tau, synaptotagmin-1 and GFAP, and decreased syntaxin-1 and H4K8ac. Our results suggested that the inflammatory insult during pregnancy could be an important risk factor for the development of Alzheimer's disease, and the H4K8 acetylation might play an important role in the underlying mechanism. This study offers a perspective for improving strategies that support healthy development and successful aging.

show abstract

Section: Lps Exposure During Pregnancy Intensified H4k8ac Reduction Isupporting

confidence: 91%

Section: Introductionmentioning

confidence: 86%

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Wang

Chen

et al. 2016

AGE

Self Cite

View full text Add to dashboard Cite

show abstract

“…The total time spent in dark compartment in 7NI and 7NI-LPS groups was significantly lower than LPS group (p < 0.05, p < 0.01, p < 0.001) but there was no significant difference between control, 7NI and 7NI-LPS groups (Figure 2). Using two way ANOVA, the results showed that there was also a significant main effects for LPS on the total time spent in light compartment at all 3( f (1,30) (1,30) = 9.14; p < 0.01)hours after receiving the shock. The total time spent in light compartment by the animals which received LPS was lower than the rats of the control group at 3, 24, 48 and 72 hour after receiving the shock (p < 0.001) whereas, in the 7NI and 7NI-LPS groups was higher than LPS group (p < 0.05, p < 0.01, p < 0.001).…”

Section: Pa Resultsmentioning

confidence: 99%

“…Using two way ANOVA, the results showed that there was also a significant main effects for LPS on latency to enter the dark compartment at all 3( f (1,35) = 336.166; p < 0.001), 24( f (1,30) = 43.51; p < 0.001), 48( f (1,35) = 37.58; p < 0.001) and 72( f (1,35) = 19.66; p < 0.001) hours after receiving shock. 7NI also significantly affected latency to enter the dark compartment at all 3( f (1,35) = 336.166; p < 0.001), 24( f (1,35) = 22.66; p < 0.001), 48 ( f (1,35) = 18.207; p < 0.001) and 72 ( f (1,35) = 18.76;p < 0.001) hours after receiving shock.…”

Section: Pa Resultsmentioning

confidence: 99%

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Anaeigoudari

Shafei

Soukhtanloo

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.

show abstract

“…Long-term administration of acarbose delays age-associated diseases and can reverse brain aging. Three-month old SAMP8 mice received 20 mg/kg/day dissolved in drinking water until 9 months of age (Tong et al, 2015; Yan et al, 2015). Serum insulin was decreased in aged SAMP8 mice while acarbose prevented this decrease and improved memory, sensorimotor skills, and anxiety as assessed by multiple behavior tests.…”

Section: Central Insulin Signaling and Memory In The Samp8 Micementioning

confidence: 99%

The SAMP8 mouse for investigating memory and the role of insulin in the brain

Rhea

Banks

2017

Experimental Gerontology

View full text Add to dashboard Cite

SAMP8 mice exhibit changes that commonly occur with normal aging late in life, but do so at a much earlier age. These changes include impairments in learning and memory as early as 8 months of age and so the SAMP8 is a useful model to investigate those age-related brain changes that may affect cognition. As brain insulin signaling and memory decline with aging, the SAMP8 model is useful for investigating these changes and interventions that might prevent the decline. This review will summarize the SAMP8 mouse model, highlight changes in brain insulin signaling and its role in memory, and discuss intranasal insulin delivery in investigating effects on insulin metabolism and memory in the SAMP8 mice.

show abstract

Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8

Cited by 30 publications

References 44 publications

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

The SAMP8 mouse for investigating memory and the role of insulin in the brain

Contact Info

Product

Resources

About