Long‐standing patchy alopecia areata along the hairline, a variety of alopecia areata mimicking frontal fibrosing alopecia and other cases of hair loss: case series of 11 patients

Starace, Michela; Guicciardi, Federica; Alessandrini, Aurora; Baraldi, Carlotta; Ravaioli, Giulia Maria; Bruni, Francesca; Piraccini, Bianca Maria

doi:10.1111/jdv.16105

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…had reported 11 cases of alopecia with peculiar appearance mimicking FFA who were demonstrated to be AA in pathology. However, clinically the presentation in this cohort was different from ours, which was described as long‐standing, chronic patches of alopecia on the frontoparietal hairline, imitating “fringe sign” of FFA and may represent another clinical variant 20 . The coexistence of AA and FFA was another suspicion, and the literature was reviewed 21–25 .…”

Section: Discussionmentioning

confidence: 63%

“…However, clinically the presentation in this cohort was different from ours, which was described as long-standing, chronic patches of alopecia on the frontoparietal hairline, imitating "fringe sign" of FFA and may represent another clinical variant. 20 The coexistence of AA and FFA was another suspicion, and the literature was reviewed. [21][22][23][24][25] Although 14 patients in this population had a history of AA, histopathology from the hairline region with single hairs revealed no signs of cicatricial alopecia.…”

Section: Discussionmentioning

confidence: 99%

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Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

Qiao,

Zhu,

Liu

et al. 2023

Int J Dermatology

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BackgroundLonely hair sign is considered as a clue to the diagnosis of frontal fibrosing alopecia (FFA).ObjectiveTo report an undescribed variant of alopecia areata (AA) with which the patient developed single hairs and other features similar to FFA and to determine the underlying mechanism.MethodsWe conducted a prospective observational study in patients who presented with receding hairline and single hairs, evaluating the clinical, trichoscopic, and histological features and their correlation. Immunochemistry studies were performed to describe the microenvironment.ResultsEighteen patients were enrolled in the study. Despite the similarity to FFA clinically, these patients showed different histopathology which revealed a normal number of pilosebaceous units, one anagen hair in one or more pilosebaceous units, and others in telogen stage, consistent with single hairs under the naked eye or under trichoscopy. The severity of the hair loss assessed by SALT was no more than 50, but the response to conventional therapy was poor.ConclusionsThis study reports a unique variant of AA. The pathological basis is an increase in the telogen hair follicles, with one anagen hair in one or more pilosebaceous units. Minimal inflammation consisting of CD3+ T lymphocytes and mast cells was demonstrated in the microenvironment.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

Qiao,

Zhu,

Liu

et al. 2023

Int J Dermatology

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“…Starace et al 65 described 11 cases of long-standing, isolated patchy AA on the frontoparietal hairline. Trichoscopic features were mainly yellow dots, short regrowing hairs, vellus, circle hairs, broken hairs, and black dots.…”

Section: Alopecia Areata (Aa)mentioning

confidence: 99%

“…Starace et al 65 . described 11 cases of long‐standing, isolated patchy AA on the frontoparietal hairline.…”

Section: Introductionmentioning

confidence: 99%

Trichoscopy – a valuable tool for identifying conditions mimicking androgenetic alopecia

Khutsishvili,

Rudnicka,

Ovcharenko

et al. 2023

Int J Dermatology

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Androgenetic alopecia (AGA) is the most prevalent type of hair loss in women and men. Recently, a European consensus group published guidelines for the diagnostic evaluation of AGA in men, women, and adolescents. This S1 guideline presents expert opinion‐based recommendations for gender‐dependent steps in the diagnostic procedure, which can easily be implemented in the daily clinical routine. For diagnosing AGA, detailed anamnesis and objective learning are not enough because there are several conditions mimicking this disease. Trichoscopy can be considered an important, non‐invasive tool for diagnosing hair and scalp disorders that may have similar clinical signs to AGA.

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Long‐standing patchy alopecia areata along the hairline, a variety of alopecia areata mimicking frontal fibrosing alopecia and other cases of hair loss: case series of 11 patients

Cited by 2 publications

References 14 publications

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

Trichoscopy – a valuable tool for identifying conditions mimicking androgenetic alopecia

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