Long-Standing Bacteremia Caused by Oral Actinobacillus actinomycetemcomitans in a Patient with a Pacemaker

Winkelhoff, A.J. van; Overbeek, B. P.; Pavide, M. J. A. M. P.; Bergh, J. P. A. van den; Ernst, Jerry; Graaff, J. de

doi:10.1093/clind/16.2.216

Cited by 34 publications

(19 citation statements)

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“…19,20) Furthermore, this microorganism has been isolated from several other nonoral infections, including brain abscess, 21) endocarditis, 22) pericarditis, 23) pneumonia, 24) and septicemia. 25,26) Recently, Desvarieux, et al found the cumulative periodontal pathogenic burden (A. actinomycetemcomitans, P. gingivalis, T. denticola, and T. forsythensis) was significantly related with carotid artery intimae thickness. 27) The present study found that A. actinomycetemcomitans was detected to a significantly greater degree from oral samples of the ACS group patients than from chronic CHD patients.…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

et al. 2007

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SUMMARYRecent epidemiological studies suggest that periodontitis is an important risk factor for coronary heart disease (CHD). The aim of this study was to evaluate the association between periodontitis and CHD, particularly acute coronary syndrome (ACS), focusing on microbiological and immunological features.Twenty-eight CHD patients, 15 with ACS and 13 with chronic CHD, were included in this study. Coronary angiography, periodontal examination, and dental radiography were performed in all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontopathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia using polymerase chain reaction.Specific serum antibody titers to the 5 periodontal pathogens were determined by enzyme-linked immunosorbent assay. It was found that 33% of the ACS patients (5/15) harbored A. actinomycetemcomitans in oral samples, whereas no A. actinomycetemcomitans (0/13) was found in the chronic CHD patients (P < 0.05). Furthermore, ACS patients showed significantly higher serum IgG titers to A. actinomycetemcomitans (P < 0.05) compared with chronic CHD. More tooth loss and alveolar bone loss were noted in ACS patients than in chronic CHD patients, although the differences were not statistically significant.Periodontal pathogens, particularly A. actinomycetemcomitans, may play a role in the development of ACS. (Int Heart J 2007; 48: 663-675)

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Section: Discussionmentioning

confidence: 99%

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

et al. 2007

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“…9 A. actinomycetemcomitans is an important periodontopathogen that is involved in the etiology of different forms of periodontal diseases, particularly in the localized juvenile and adult periodontitis, and also in several extra-oral infections such as endocarditis, pericarditis, pneumonias, septicemias, and abscesses. 3,10,17 F. nucleatum has also been considered an important periodontopathogen for the development of gingivitis and periodontitis and as the most common anaerobic species found in human and animal infections, particularly in the oral cavity. 2 The isolation and identification of periodontal pathogens characterize an important tool for increasing knowledge on periodontal microbiota as well as on the etiology and progression of periodontal infections.…”

Section: Introductionmentioning

confidence: 99%

Detection of pathogens from periodontal lesions

Malheiros

Ávila-Campos

2004

Rev. Saúde Pública

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ObjectiveTo comparatively detect A. actinomycetemcomitans and F. nucleatum from periodontal and healthy sites. Methods Subgingival clinical samples from 50 periodontitis adult patients and 50 healthy subjects were analyzed. Both organisms were isolated using a trypticase soy agarbacitracin-vancomycin (TSBV) medium and detected by PCR. Conventional biochemical tests were used for bacteria identification. Results A. actinomycetemcomitans and F. nucleatum were isolated in 18% and 20% of the patients, respectively, and in 2% and 24% of healthy subjects. Among A. actinomycetemcomitans isolates, biotype II was the most prevalent. Primer pair AA was 100% sensitive in the detection of A. actinomycetemcomitans from both subject groups. Primers ASH and FU were also 100% sensitive to detect this organism in healthy subject samples. Primer pair FN5047 was more sensitive to detect F. nucleatum in patients or in healthy samples than primer 5059S. Primers ASH and 5059S were more specific in the detection of A. actinomycetemcomitans and F. nucleatum, respectively, in patients and in healthy subject samples. Conclusions PCR is an effective tool for detecting periodontal pathogens in subgingival samples, providing a faster and safer diagnostic tool of periodontal diseases. The method's sensitivity and specificity is conditioned by the choice of the set of primers used. Resumo Objetivo

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“…Die gesuchten Keime in der vorliegenden Studie, besonders A. actinomycetemcomitans, sind sowohl während der Bakteriämien als auch beim Auftreten einer Endokarditis gefunden worden [43,45]. Ebenso wie C. pneumoniae können auch A. actinomycetemcomitans in die eukariotischen Zellen eindringen, wobei sie dieselben Mechanismen benutzen wie andere invasive Bakterien [31].…”

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Nachweis parodontal pathogener Mikroorganismen in atheromatösen Plaques Vorläufige Ergebnisse

Mastragelopulos¹,

Haraszthy

Zambon

et al. 2002

Chirurg

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Long-Standing Bacteremia Caused by Oral Actinobacillus actinomycetemcomitans in a Patient with a Pacemaker

Cited by 34 publications

References 11 publications

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

Detection of pathogens from periodontal lesions

Nachweis parodontal pathogener Mikroorganismen in atheromatösen Plaques Vorläufige Ergebnisse

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